The Registry of Toxic Effects of Chemical Substances

4 - Heptanone

RTECS #: MJ5600000

CAS #: 123-19-3

UPDATE: November 2004 MW: 114.21 MF: C7H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Butyrone
  2. Dipropyl ketone
  3. Dipropyl ketone (ACGIH)
  1. GBL
  2. Heptan - 4 - one
  3. Propyl ketone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,286,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,286,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 2,690 ppm/6 hour Behavioral: Sleep

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		38MKAJ 2C,4764,1982
intravenous
mouse 		lowest published lethal dose: 271 mg/kg Behavioral: Altered sleep time (including change in righting reflex) APTOA6 37,56,1975
oral
rat 		lethal dose (50 percent kill): 3,730 µL/kg N/R TXAPA9 28,313,1974
skin
rabbit 		lethal dose (50 percent kill): 5,660 µL/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 30 gm/kg/3 week- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0571116
oral
rat 		lowest published toxic dose: 130 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0571116


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (235 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 235 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIPROPYL KETONE-air 10 hour time-weighted average 50 ppm NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Primary Irritant

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