The Registry of Toxic Effects of Chemical Substances
3 - Heptanone |
UPDATE: November 2004 | MW: 114.21 | MF: C7H14O |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 100 mg | mild | FCTXAV 16,731,1978 |
eye rabbit | 500 mg/24 hour | mild | 85JCAE -,286,1986 |
skin rabbit | 500 mg open irritation test | mild | UCDS** 3/12/1969 |
skin rabbit | 500 mg/24 hour | moderate | FCTXAV 16,731,1978 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published lethal concentration: 2,000 ppm/4 hour | N/R | JIHTAB 31,343,1949 |
oral rat | lethal dose (50 percent kill): 2,760 mg/kg | N/R | JIHTAB 31,60,1949 |
skin rabbit | lethal dose (50 percent kill): >20 mL/kg | N/R | UCDS** 3/12/1969 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 2,863 mg/m3/16 hour/4 day- intermittent |
Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath | VCVGK* -,430,1994 |
oral rat | lowest published toxic dose: 140,000 mg/kg/14 week- intermittent |
Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath | VCVGK* -,430,1994 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 50 ppm | DTLVS* TLV/BEI,2002 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 50 ppm;short term exposure limit 75 ppm | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | short term exposure limit 75 ppm | DTLVS* TLV/BEI,2002 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 50 ppm (230 mg/m3) | DTLVS* 3,105,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 50 ppm (230 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 50 ppm (230 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 50 ppm (230 mg/m3) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 50 ppm (230 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 50 ppm (230 mg/m3), JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 50 ppm (230 mg/m3), JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 50 ppm (234 mg/m3), JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 50 ppm (230 mg/m3), JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 50 ppm (230 mg/m3), JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 25 ppm (115 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 163 mg/m3, 2003 | |
Occupational Exposure Limit - SWEDEN | time-weighted average 25 ppm (120 mg/m3), short term exposure limit 50 ppm (250 mg/m3), JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 50 ppm (230 mg/m3), JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 50 ppm (237 mg/m3), short term exposure limit 100 ppm, Skin, SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; short term exposure limit 75 ppm | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 75 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL BUTYL KETONE-air | 10 hour time-weighted average 50 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 36330; Number of Industries 8; Total Number of Facilities 320; Number of Occupations 14; Total Number of Employees Exposed 1,923 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 36330![]() Number of Industries 20; Total Number of Facilities 2,103; Number of Occupations 9; Total Number of Employees Exposed 11,318; Total Number of Female Employees Exposed 1,164 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Ketones II, 1301 |
REFERENCES: | |
CODEN |
REFERENCE |
85JCAE | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
FCTXAV | Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. |
JIHTAB | Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
UCDS** | Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |