The Registry of Toxic Effects of Chemical Substances

2 - Heptanone

RTECS #: MJ5075000

CAS #: 110-43-0

UPDATE: November 2004 MW: 114.21 MF: C7H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Amyl - methyl - cetone (French)
  2. Ketone, methyl pentyl
  3. Methyl n - amyl ketone
  4. Methyl n - amyl ketone (ACGIH:OSHA)
  1. Methyl pentyl ketone
  2. Methyl - amyl - cetone (French)
  3. n - Amyl methyl ketone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		14 mg/24 hour open irritation test mild AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 7,000 mg/m3/4 hour Lung, Thorax, or Respiration: Cough VCVGK* -,429,1994
inhalation
guinea pig 		lowest published toxic concentration: 9,300 mg/m3/4 hour Behavioral: General anesthetic VCVGK* -,429,1994
inhalation
guinea pig 		lowest published lethal concentration: 22,400 mg/m3/4 hour N/R VCVGK* -,429,1994
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R AIHAAP 23,95,1962
intraperitoneal
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R 38MKAJ 2C,4757,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4757,1982
oral
mouse 		lethal dose (50 percent kill): 730 mg/kg N/R APJUA8 12,79,1962
oral
rat 		lethal dose (50 percent kill): 1,670 mg/kg N/R UCDS** 8/11/1958
skin
rabbit 		lethal dose (50 percent kill): 12,600 µL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 45,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight 		FCTXAV 10,625,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (465 mg/m3) DTLVS* 3,157,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (465 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (465 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (465 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (465 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (235 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (233 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (235 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (120 mg/m3), short term exposure limit 50 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 233 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM LTEL 50 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL AMYL KETONE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 36340;
Number of Industries 10;
Total Number of Facilities 489;
Number of Occupations 8;
Total Number of Employees Exposed 3,345
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 36340;
Number of Industries 62;
Total Number of Facilities 5,080;
Number of Occupations 47;
Total Number of Employees Exposed 78,196;
Total Number of Female Employees Exposed 17,866


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent in metal roll coatings and in synthetic resin finishes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb, Yugoslavia) V.1-41, 1951-91. For publisher information, see ACPHEE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent in metal roll coatings and in synthetic resin finishes

RTECS Compound Description:
   Primary Irritant

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