The Registry of Toxic Effects of Chemical Substances

Heptane

RTECS #: MI7700000

CAS #: 142-82-5

UPDATE: November 2004 MW: 100.23 MF: C7H16


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Dipropyl methane
  2. Eptani (Italian)
  3. Gettysolve - C
  4. Heptan (Polish)
  5. Heptane (ACGIH:OSHA)
  1. Heptanen (Dutch)
  2. n - Heptane (OSHA)
  3. Heptyl hydride
  4. n - Heptane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration : >17,937 ppm/4 hour N/R NTIS** OTS0556754
inhalation
human 		lowest published toxic concentration: 1,000 ppm/6 minute Behavioral: Hallucinations, distorted perceptions BMRII* 2979,-,1929
inhalation
mouse 		lowest published lethal concentration: 59 gm/m3/41 minute Behavioral: Convulsions or effect on seizure threshold BIZEA2 115,235,1921
inhalation
mouse 		lowest published lethal concentration: 75,000 mg/m3/2 hour N/R VCVGH* -,35,1990
inhalation
rat 		lethal concentration (50 percent kill): 103 gm/m3/4 hour N/R GTPZAB 32(10),23,1988
inhalation
rat 		lowest published lethal concentration: 65,000 mg/m3 N/R VCVGH* -,35,1990
intravenous
mouse 		lethal dose (50 percent kill): 222 mg/kg N/R JPMSAE 67,566,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 4,000 ppm/6 hour/28 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Ear: Change in cochlear structure or function

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		PHTOEH 76,41,1995
inhalation
rat 		lowest published toxic concentration: 420 mg/m3/12 hour/2 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		VCVGH* -,35,1990
intraperitoneal
rat 		lowest published toxic dose: 9,625 mg/kg/7 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TOLED5 14,169,1982
intraperitoneal
rat 		lowest published toxic dose: 8,840 mg/kg/45 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		JJATDK 8,81,1988
oral
rat 		lowest published toxic dose: 60 gm/kg/3 week- intermittent Liver: Changes in liver weight NTIS** OTS0571116
oral
rat 		lowest published toxic dose: 260 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0571116


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm;short term exposure limit 500 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 500 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (2000 mg/m3) DTLVS* 3,124,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 400 ppm (1600 mg/m3), short term exposure limit 500 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 500 ppm (2000 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 400 ppm (1640 mg/m3), short term exposure limit 500 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (820 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 300 ppm (1200 mg/m3), short term exposure limit 500 ppm (2000 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 400 ppm (1600 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 500 ppm (2000 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (820 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1200 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 200 ppm (800 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1200 mg/m3, MAC(short term exposure limit) 2000 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 200 ppm, JAN1993
Occupational Exposure Limit - SWEDEN NGV 200 ppm (800 mg/m3), KTV 300 ppm (1200 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 400 ppm (1600 mg/m3), KZG- week 800 ppm (3200 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 400 ppm (1600 mg/m3), short term exposure limit 500 ppm, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 500 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 500 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEPTANE-air 10 hour time-weighted average 85 ppm;
ceiling concentration 440 ppm/15 minute 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 36060;
Number of Industries 153;
Total Number of Facilities 20,154;
Number of Occupations 110;
Total Number of Employees Exposed 221,101
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 36060;
Number of Industries 191;
Total Number of Facilities 37,852;
Number of Occupations 134;
Total Number of Employees Exposed 449,487;
Total Number of Female Employees Exposed 44,550


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in graphics, textiles, adhesives and coatings
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI.
BMRII* "U.S. Bureau of Mines Report of Investigation No. 2979," Patty, F.A., and W.P. Yant, 1929
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in graphics, textiles, adhesives and coatings

RTECS Compound Description:
   Drug
   Human Data

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