The Registry of Toxic Effects of Chemical Substances

Guanidine, 1,3 - diphenyl -

RTECS #: MF0875000

CAS #: 102-06-7

UPDATE: October 2002 MW: 211.29 MF: C13H13N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Accelerator D
  2. Denax
  3. Denax DPG
  4. 1,3 - Difenylguanid (Czech)
  5. Diphenylguanidine
  6. sym - Diphenylguanidine
  7. N,N' - Diphenylguanidine
  8. 1,3 - Diphenylguanidine
  9. DPG accelerator
  10. Dwufenyloguanidyna (Polish)
  1. Melaniline
  2. NCI - C60924
  3. Nocceler D
  4. USAF B - 19
  5. USAF EK - 1270
  6. Vulcafor DPG
  7. Vulkacit D
  8. Vulkacit D/C
  9. Vulkazit


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		1%/48 hour CODEDG 11,256,1984


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay mouse
Salmonella typhimurium 		36 ng/kg JEPOEC 6(1-2),293,1985
mutation in microorganisms Salmonella typhimurium 360 ng/plate (+enzymatic activation step) JEPOEC 6(1-2),293,1985
mutation in microorganisms Salmonella typhimurium 33 µg/plate (-enzymatic activation step) ENMUDM 8(Suppl 7),1,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lowest published toxic dose: 224 mg/kg (56 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JTEHD6 11,869,1983
oral
mouse 		lowest published toxic dose: 76 mg/kg (1-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JEPTDQ 4(1),451,1980
oral
mouse 		lowest published toxic dose: 190 mg/kg (1-19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JEPTDQ 4(1),451,1980
oral
mouse 		lowest published toxic dose: 56 mg/kg (7 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 		JTEHD6 11,869,1983
oral
mouse 		lowest published toxic dose: 196 mg/kg (49 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JTEHD6 11,869,1983
oral
mouse 		lowest published toxic dose: 140 mg/kg (35 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JTEHD6 11,869,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 75 mg/kg N/R MEPAAX 16,35,1965
intravenous
dog 		lowest published lethal dose: 25 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tetany 		CRSBAW 143,815,1949
oral
guinea pig 		lethal dose (50 percent kill): 250 mg/kg N/R 85JCAE -,974,1986
oral
mammal (species unspecified) 		lowest published lethal dose: 250 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		JIDHAN 13,87,1931
oral
mouse 		lethal dose (50 percent kill): 150 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia 		SRTCAC 36(1-4),10,1989
oral
rat 		lethal dose (50 percent kill): 323 mg/kg N/R NTPTR* NIH-95-3933
oral
rabbit 		lethal dose (50 percent kill): 250 mg/kg N/R 85JCAE -,974,1986
subcutaneous
guinea pig 		lowest published lethal dose: 200 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tetany 		CRSBAW 143,815,1949
skin
rabbit 		lethal dose (50 percent kill): >794 mg/kg N/R NTPTR* NIH-95-3933
unreported route
mouse 		lethal dose (50 percent kill): 258 mg/kg Blood: Normocytic anemia GISAAA 43(7),35,1978
unreported route
rat 		lethal dose (50 percent kill): 323 mg/kg Blood: Normocytic anemia GISAAA 43(7),35,1978
unreported route
rabbit 		lethal dose (50 percent kill): 246 mg/kg Blood: Normocytic anemia GISAAA 43(7),35,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3,808 mg/kg/17 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 43(7),35,1978
oral
rat 		lowest published toxic dose: 1,313 mg/kg/7 day- intermittent Liver: Other changes

Blood: Other changes 		KHZDAN 15,234,1972
oral
rat 		lowest published toxic dose: 1,500 mg/kg/20 day- intermittent Liver: Other changes

Blood: Other changes 		KHZDAN 15,234,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 27760;
Number of Industries 10;
Total Number of Facilities 326;
Number of Occupations 21;
Total Number of Employees Exposed 14,344
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 27760;
Number of Industries 14;
Total Number of Facilities 874;
Number of Occupations 40;
Total Number of Employees Exposed 28,146;
Total Number of Female Employees Exposed 4,339


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a vulcanization accelerator
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9186;8EHQ-0892-9256
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-42, October 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-

Used as a vulcanization accelerator

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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