The Registry of Toxic Effects of Chemical Substances
Guanidine, cyano - |
UPDATE: March 1999 | MW: 84.10 | MF: C2H4N4 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
|
N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
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intraperitoneal | mouse
lethal dose (50 percent kill): >4 gm/kg
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N/R
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APTOA6 8,329,1952
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intraperitoneal | rabbit
lethal dose (50 percent kill): >3 gm/kg
|
N/R
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APTOA6 8,329,1952
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oral | mouse
lethal dose (50 percent kill): >10 gm/kg
|
N/R
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TOVEFN (4),39,1998
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oral | rat
lethal dose : >500 mg/kg
|
N/R
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NCNSA6 5,17,1953
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unreported route | rat
lowest published lethal dose: 600 mg/kg
|
N/R
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BCPCA6 14,1325,1965
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
inhalation | guinea pig
lowest published toxic concentration: 2,400 µg/m3/4 week- intermittent
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Blood: Other changes
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TOVEFN (4),39,1998
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inhalation | rat
lowest published toxic concentration: 2,400 µg/m3/4 week- intermittent
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Blood: Other changes
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TOVEFN (4),39,1998
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oral | rat
lowest published toxic dose: 273 gm/kg/13 week- continuous
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Liver: Changes in liver weight | Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ESKHA5 (109),61,1991
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REVIEWS:
ORGANIZATION
|
STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
|
N/R
|
N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 83038; | Number of Industries 27; Total Number of Facilities 720; Number of Occupations 55; Total Number of Employees Exposed 19,281
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 83038; |
Number of Industries 48; Total Number of Facilities 1,639; Number of Occupations 50; Total Number of Employees Exposed 35,475; Total Number of Female Employees Exposed 7,043 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
APTOA6
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Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher
information, see PHTOEH
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BCPCA6
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Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY
10523) V.1- 1958-
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ESKHA5
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Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei
Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
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NCNSA6
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National Academy of Sciences, National Research Council, Chemical-Biological Coordination
Center, Review. (Washington, DC)
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TOVEFN
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Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
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