The Registry of Toxic Effects of Chemical Substances

Glycine, N,N - bis (carboxymethyl) - , trisodium salt

RTECS #: MB8400000

CAS #: 5064-31-3

UPDATE: August 2003 MW: 257.10 MF: C6H6NO6•3Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acetic acid, nitrilotri - , trisodium salt
  2. Cheelox nta - 14, - Na3
  3. N,N - Bis (carboxymethyl) glycine trisodium salt
  4. Hampshire NTA
  1. Nitrilotriacetic acid, trisodium salt
  2. Trisodium nitrilotriacetate
  3. Trisodium nitrilotriacetic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 3 mmol/L MUREAV 343,1,1995
micronucleus test hamster lung 2 mmol/L MUREAV 343,1,1995
morphological transform mouse embryo 2 mg/L EMMUEG 12,21,1988
morphological transform rat embryo 495 µg/plate JJATDK 1,190,1981
other mutation test systems hamster lung 3 mmol/L MUREAV 343,1,1995
specific locus test oral
Drosophila melanogaster 		5,200 µmol/L MUREAV 262,253,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 39 gm/kg (8 week male/8 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FCTXAV 9,509,1971
oral
rat 		lowest published toxic dose: 8 gm/kg (8 week male/8 week prior to copulation-3 week after birth) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FCTXAV 9,509,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 70,300 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors 		JJIND8 66,869,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 254 mg/kg N/R TXAPA9 18,398,1971
oral
dog 		lethal dose (50 percent kill): >5 gm/kg Gastrointestinal: Nausea or vomiting TXAPA9 18,398,1971
oral
monkey 		lethal dose (50 percent kill): 750 mg/kg Gastrointestinal: Nausea or vomiting TXAPA9 18,398,1971
oral
mouse 		lethal dose (50 percent kill): 681 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
oral
rat 		lethal dose (50 percent kill): 1,100 mg/kg Gastrointestinal: Nausea or vomiting TXAPA9 18,398,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 180 gm/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in erythrocyte (RBC) count 		TXAPA9 18,398,1971
oral
rat 		lowest published toxic dose: 56,305 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) FCTOD7 20,433,1982
oral
rat 		lowest published toxic dose: 219 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Other metals

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 21,244,1972
oral
rat 		lowest published toxic dose: 67,200 mg/kg/28 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes 		NTIS** OTS0543794


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 48,181,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,385,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,385,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 73,385,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,298,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0951;
Number of Industries 82;
Total Number of Facilities 7,988;
Number of Occupations 64;
Total Number of Employees Exposed 77,882
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0951;
Number of Industries 95;
Total Number of Facilities 11,433;
Number of Occupations 97;
Total Number of Employees Exposed 224,263;
Total Number of Female Employees Exposed 60,818


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an industrial chemical

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 37291-81-9
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