The Registry of Toxic Effects of Chemical Substances

Glutaronitrile, 2 - bromo - 2 - (bromomethyl) -

RTECS #: MA5599000

CAS #: 35691-65-7

UPDATE: August 2004 MW: 265.96 MF: C6H6Br2N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Dibromo - 2,4 - dicyanobutane
  2. 1 - Bromo - 1 - (bromomethyl) - 1,3 - propanedicarbonitrile
  3. 2 - Bromo - 2 - (bromomethyl) glutaronitrile
  1. Methyldibromoglutaronitrile
  2. Pentanedinitrile, 2 - bromo - 2 - (bromomethyl) -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe JACTDZ 15,140,1996
skin
guinea pig 		1%/24 hour CODEDG 28,149,1993
skin
rabbit 		500 mg moderate JACTDZ 15,140,1996


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,750 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOLED5 18(Suppl 1),158,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >13 gm/m3/4 hour N/R JACTDZ 15,140,1996
oral
rat 		lethal dose (50 percent kill): 515 mg/kg N/R JACTDZ 15,140,1996
skin
guinea pig 		lowest published toxic dose: 0.3 pph Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 28,149,1993
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R JACTDZ 15,140,1996


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 380 mg/kg/13 week- continuous Endocrine: Changes in thyroid weight JACTDZ 15,140,1996
skin
rat 		lowest published toxic dose: 84 gm/kg/3 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Skin: After systemic exposure: Dermatitis, other 		JACTDZ 15,140,1996
skin
rabbit 		lowest published toxic dose: 120 mg/kg/4 week- intermittent Blood: Pigmented or nucleated red blood cells JACTDZ 15,140,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,172,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1017;
Number of Industries 9;
Total Number of Facilities 512;
Number of Occupations 10;
Total Number of Employees Exposed 17,713;
Total Number of Female Employees Exposed 3,345


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial preservative
NTP Carcinogenesis studies; on test (prechronic studies), October 2000


REFERENCES:

CODEN
REFERENCE
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an industrial preservative

RTECS Compound Description:
   Tumorigen
   Drug
   Reproductive Effector
   Human Data
   Primary Irritant

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