The Registry of Toxic Effects of Chemical Substances
Glutaraldehyde |
UPDATE: February 2005 | MW: 100.13 | MF: C5H8O2 |
SYNONYMS:
|
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
eye | rabbit
1 mg
|
severe
|
UCDS** 1/30/1970
|
eye | rabbit
250 µg/24 hour
|
severe
|
85JCAE -,272,1986
|
eye | woman
200 ppb
|
severe
|
TOXID9 72,292,2003
|
skin | human
6 mg/3 day- intermittent
|
severe
|
85DKA8 -,127,1977
|
skin | rabbit
13 mg open irritation test
|
mild
|
UCDS** 1/30/1970
|
skin | rabbit
2 mg/24 hour
|
severe
|
85JCAE -,272,1986
|
|
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
cytogenetic analysis
|
hamster
ovary
|
160 µg/L
|
ENMUDM 7,1,1985
|
cytogenetic analysis
|
inhalation | mouse
0.5 ppb
|
EMMUEG 39,69,2002
|
cytogenetic analysis
|
inhalation | rat
0.5 ppb
|
EMMUEG 39,69,2002
|
DNA damage
|
chicken
leukocyte
|
8 pph
|
CELLB5 5,45,1975
|
DNA damage
|
hamster
fibroblast
|
2,500 ppm
|
SFCRAO 23,346,1970
|
DNA damage
|
human
lymphocyte
|
10 µmol/L
|
EMMUEG 17(Suppl 19),71,1991
|
DNA damage
|
human
leukocyte
|
5 µmol/L
|
MUREAV 468,93,2000
|
DNA damage
|
mammal (species unspecified)
lymphocyte
|
2,500 µmol/L
|
MUREAV 283,131,1992
|
DNA repair
|
Bacillus subtilis
|
1 mg/L
|
MUREAV 193,21,1988
|
mutation in microorganisms
|
Escherichia coli
|
62,500 ng/plate (-enzymatic activation step)
|
MUREAV 412,17,1998
|
mutation in microorganisms
|
Salmonella typhimurium
|
500 nmol/L (+enzymatic activation step)
|
MUREAV 148,25,1985
|
mutation in microorganisms
|
Salmonella typhimurium
|
150 µg/plate (-enzymatic activation step)
|
ENMUDM 5(Suppl 1),3,1983
|
mutation in microorganisms
|
Salmonella typhimurium
|
0.5 mg/plate/48 hour (+enzymatic activation step)
|
JAPTO* 22,45,2001
|
mutation in microorganisms
|
Salmonella typhimurium
|
0.25 mg/plate/3 day (-enzymatic activation step)
|
MUREAV 521,19,2002
|
mutation in mammalian somatic cells
|
mouse
lymphocyte
|
8 mg/L
|
EMMUEG 11,91,1988
|
other mutation test systems
|
non-mammalian species
other cell types
|
50 mmol/L
|
ECREAL 95,233,1975
|
sister chromatid exchange
|
hamster
ovary
|
110 µg/L
|
ENMUDM 7,1,1985
|
specific locus test
|
inhalation | mouse
0.5 ppb
|
EMMUEG 39,69,2002
|
specific locus test
|
inhalation | rat
0.5 ppb
|
EMMUEG 39,69,2002
|
|
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | mouse
lowest published toxic dose: 50 gm/kg (6-15 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 22,51,1980
|
oral | mouse
lowest published toxic dose: 8 gm/kg (6-15 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
TJADAB 22,51,1980
|
oral | rat
lowest published toxic dose: 875 mg/kg (35 day male)
|
Reproductive: Paternal effects: Testes, epididymis, sperm duct | Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
OYYAA2 12,11,1976
|
oral | rat
lowest published toxic dose: 4,370 mg/kg (35 day prior to copulation)
|
Reproductive: Maternal effects: Uterus, cervix, vagina
|
OYYAA2 12,11,1976
|
oral | rat
lowest published toxic dose: 1 gm/kg (6-15 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
TOLED5 63,147,1992
|
oral | rat
lowest published toxic dose: 5.3 gm/kg (84 day male/70 day prior to copulation-4 week after birth)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | Reproductive: Effects on newborn: Other postnatal measures or effects Reproductive: Effects on newborn: Delayed effects
JTEHD6 61,107,2000
|
oral | rat
lowest published toxic dose: 167.4 mg/kg (multigenerations)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | Reproductive: Effects on newborn: Delayed effects
JTEHD6 61,107,2000
|
oral | rabbit
lowest published toxic dose: 585 mg/kg (7-19 day pregnant)
|
Reproductive: Other effects on female | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** OTS0526410
|
|
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | rat
lowest published toxic dose: 2,912 mg/kg/104 week- continuous
|
Tumorigenic: Carcinogenic by RTECS criteria | Blood: Leukemia Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 175,177,2002
|
oral | rat
lowest published toxic dose: 2,912 mg/kg/104 week- intermittent
|
Tumorigenic: Carcinogenic by RTECS criteria | Blood: Leukemia Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 175,177,2002
|
|
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lethal concentration (50 percent kill): 480 mg/m3/4 hour
|
N/R
|
EPASR* 8EHQ-1290-1008
|
inhalation | rabbit
lowest published toxic concentration: 500 ppm
|
Eye: Conjunctiva irritation | Lung, Thorax, or Respiration: Cough
VCVGK* -,404,1984
|
inhalation | woman
lowest published toxic concentration: 200 ppb
|
Olfaction: Other olfaction effects
|
TOXID9 72,292,2003
|
intraperitoneal | mouse
lethal dose (50 percent kill): 13,900 µg/kg
|
N/R
|
IYKEDH 10,232,1979
|
intraperitoneal | rat
lethal dose (50 percent kill): 17,900 µg/kg
|
N/R
|
IYKEDH 10,232,1979
|
intravenous | mouse
lethal dose (50 percent kill): 15,400 µg/kg
|
N/R
|
OYYAA2 19,503,1980
|
intravenous | rat
lethal dose (50 percent kill): 9,800 µg/kg
|
N/R
|
EPASR* 8EHQ-1290-1008
|
oral | duck
lethal dose (50 percent kill): 820 mg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Food intake (animal)
NTIS** OTS0526410-1
|
oral | guinea pig
lethal dose (50 percent kill): 50 mg/kg
|
Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement
GISAAA 52(3),77,1987
|
oral | mouse
lethal dose (50 percent kill): 100 mg/kg
|
N/R
|
OYYAA2 19,503,1980
|
oral | mouse
lethal dose (50 percent kill): 231 mg/kg
|
Lung, Thorax, or Respiration: Other changes | Liver: Other changes Kidney, Ureter, and Bladder: Other changes
VCVGK* -,404,1984
|
oral | rat
lethal dose (50 percent kill): 134 mg/kg
|
N/R
|
OYYAA2 19,503,1980
|
oral | rat
lethal dose (50 percent kill): 140 mg/kg
|
Lung, Thorax, or Respiration: Other changes | Liver: Other changes Kidney, Ureter, and Bladder: Other changes
VCVGK* -,404,1984
|
subcutaneous | mouse
lethal dose (50 percent kill): >590 mg/kg
|
N/R
|
NIIRDN -,395,1995
|
subcutaneous | rat
lethal dose (50 percent kill): >750 mg/kg
|
N/R
|
NIIRDN -,395,1995
|
skin | mouse
lethal dose (50 percent kill): >5,840 mg/kg
|
Skin: After systemic exposure: Dermatitis, other
|
OYYAA2 12,11,1976
|
skin | rat
lethal dose (50 percent kill): >2,500 mg/kg
|
Skin: After systemic exposure: Dermatitis, other
|
OYYAA2 12,11,1976
|
skin | rabbit
lethal dose (50 percent kill): 560 µL/kg
|
N/R
|
UCDS** 11/4/1971
|
|
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mouse
lowest published toxic concentration: 16 ppm/6 hour/2 week- intermittent
|
Olfaction: Other olfaction effects | Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-93-3348
|
inhalation | mouse
lowest published toxic concentration: 1,000 ppb/6 hour/13 week- intermittent
|
Olfaction: Other olfaction effects | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-93-3348
|
inhalation | mouse
lowest published toxic concentration: 250 ppb/6 hour/2 year- intermittent
|
Olfaction: Other olfaction effects | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 48,341,1999
|
inhalation | rat
lowest published toxic concentration: 5 ppm/6 hour/2 week- intermittent
|
Olfaction: Other olfaction effects | Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-93-3348
|
inhalation | rat
lowest published toxic concentration: 1,000 ppb/6 hour/13 week- intermittent
|
Olfaction: Other olfaction effects | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NIH-93-3348
|
inhalation | rat
lowest published toxic concentration: 500 ppb/6 hour/2 year- intermittent
|
Olfaction: Other olfaction effects | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 48,341,1999
|
oral | rat
lowest published toxic dose: 12,376 mg/kg/2 year- continuous
|
Kidney, Ureter, and Bladder: Other changes in urine composition | Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 15,203,1995
|
oral | rat
lowest published toxic dose: 54,600 µg/kg/26 week- intermittent
|
Liver: Fatty liver degeneration | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 52(3),77,1987
|
oral | rat
lowest published toxic dose: 11,410 mg/kg/7 day- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
|
NTIS** OTS0535072
|
oral | rat
lowest published toxic dose: 122.5 mg/kg/1 week- continuous
|
Behavioral: Fluid intake
|
JTEHD6 61,107,2000
|
oral | rat
lowest published toxic dose: 967 mg/kg/2 week- continuous
|
Behavioral: Food intake (animal)
|
JTEHD6 61,107,2000
|
oral | rat
lowest published toxic dose: 688.8 mg/kg/1 week- continuous
|
Behavioral: Food intake (animal)
|
JTEHD6 61,107,2000
|
oral | rat
lowest published toxic dose: 117.5 mg/kg/235 day- intermittent
|
Endocrine: Changes in thymus weight | Blood: Normocytic anemia Blood: Changes in other cell count (unspecified)
VCVGK* -,404,1994
|
oral | rat
lowest published toxic dose: 1,547 mg/kg/13 week- intermittent
|
Kidney, Ureter, and Bladder: Urine volume decreased or anuria | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 175,177,2002
|
oral | rat
lowest published toxic dose: 9,282 mg/kg/78 week- intermittent
|
Kidney, Ureter, and Bladder: Urine volume decreased or anuria | Kidney, Ureter, and Bladder: Changes in kidney weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 175,177,2002
|
subcutaneous | rat
lowest published toxic dose: 175 mg/kg/35 day- continuous
|
Liver: Changes in liver weight | Endocrine: Changes in spleen weight Blood: Normocytic anemia
OYYAA2 12,11,1976
|
|
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
Not Classifiable as a Human Carcinogen
|
DTLVS* TLV/BEI,2003
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
ceiling concentration 0.05 ppm (sen)
|
DTLVS* TLV/BEI,2003
|
TOXICOLOGY REVIEW
|
|
DPIRDU 1(7),2,1981
|
TOXICOLOGY REVIEW
|
|
CRTXB2 22,143,1992
|
TOXICOLOGY REVIEW
|
|
JACTDZ 15,98,1996
|
TOXICOLOGY REVIEW
|
|
MUREAV 5432012003
|
|
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
|
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
|
FEREAC 54,7740,1989
|
Occupational Exposure Limit - AUSTRALIA
|
time-weighted average 0.2 ppm (0.7 mg/m3), JAN1993
|
Occupational Exposure Limit - AUSTRIA
|
MAK 0.2 ppm (0.8 mg/m3), JAN1999
|
Occupational Exposure Limit - BELGIUM
|
time-weighted average 0.2 mg/m3, short term exposure limit 0.82 mg/m3, JAN1993
|
Occupational Exposure Limit - DENMARK
|
time-weighted average 0.2 ppm (0.8 mg/m3), JAN1999
|
Occupational Exposure Limit - FINLAND
|
CEILING 0.1 ppm, JAN1999
|
Occupational Exposure Limit - FRANCE
|
VLE 0.2 ppm (0.8 mg/m3), JAN1999
|
Occupational Exposure Limit - GERMANY
|
MAK 0.21ppm (0.4 mg/m3), JAN1999
|
Occupational Exposure Limit - NORWAY
|
time-weighted average 0.2 ppm (0.8 mg/m3), JAN1999
|
Occupational Exposure Limit - THE NETHERLANDS
|
MAC- continuous 0.25 mg/m3, 2003
|
Occupational Exposure Limit - RUSSIA
|
short term exposure limit 5 mg/m3, JAN1993
|
Occupational Exposure Limit - SWEDEN
|
short term exposure limit 0.2 ppm (0.8 mg/m3), Skin, JAN1999
|
Occupational Exposure Limit - SWITZERLAND
|
MAK- week 0.2 ppm (0.8 mg/m3), KZG- week 0.4 ppm (1.6 mg/m3), JAN1999
|
Occupational Exposure Limit - UNITED KINGDOM
|
time-weighted average 0.05 ppm (0.2 mg/m3), SEP2000
|
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | ceiling concentration 0.05 ppm (sen)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
ceiling concentration 0.05 ppm (sen) |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GLUTARALDEHYDE-air
|
ceiling concentration 0.2 ppm
|
NIOSH* DHHS #92-100,1992
|
National Occupational Hazard Survey 1974
|
National Occupational Hazard Survey 1974: Hazard Code: 84349; | Number of Industries 11; Total Number of Facilities 2,069; Number of Occupations 25; Total Number of Employees Exposed 12,954
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: 84349; |
Number of Industries 35; Total Number of Facilities 9,475; Number of Occupations 63; Total Number of Employees Exposed 367,330; Total Number of Female Employees Exposed 265,564 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
|
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
Used in leather tanning and in embalming fluids and as a germicide and crosslinking agent
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
|
NIOSH Analytical Method, 1994: Glutaraldehyde, 2532
|
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
|
NTP Toxicity studies, RPT# TOX-25, October 2000
|
OSHA ANALYTICAL METHOD #ID-64
|
|
REFERENCES:
CODEN
|
|
REFERENCE
85DKA8
|
"Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar,
eds., New York, Academic Press, Inc. 1977
|
85JCAE
|
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
|
CELLB5
|
Cell (Cambridge, Mass.). (MIT Press, 28 Carleton St., Cambridge, MA 02142) V.1- 1974-
|
CRTXB2
|
CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton,
FL 33431) V.1- 1971-
|
DPIRDU
|
Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave.,
New York, NY 10003) V.1- 1981-
|
DTLVS*
|
The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
|
ECREAL
|
Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10-
1950-
|
EMMUEG
|
Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.10- 1987-
|
ENMUDM
|
Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see
EMMUEG.
|
EPASR*
|
United States Environmental Protection Agency, Office of Pesticides and Toxic Substances.
(U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
|
FEREAC
|
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
|
GISAAA
|
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
|
IYKEDH
|
Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome,
Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
|
JACTDZ
|
Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New
York, NY 10128) V.1-12, 1982-1993. Discontinued.
|
JAPTO*
|
Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex,
PO22 9SA England) V.1- 1981-
|
JTEHD6
|
Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
NIIRDN
|
Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
|
NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
|
NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
|
NTPTR*
|
National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709)
No.206-
|
OYYAA2
|
Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1-
1967-
|
SFCRAO
|
Collection of Papers Presented at the Annual Symposium on Fundamental Cancer Research.
(Baltimore, MD) V.1-29, 1946-76. For publisher information, see AFCPDR.
|
TJADAB
|
Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.1- 1968-
|
TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
|
TXCYAC
|
Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
|
UCDS**
|
Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
|
VCVGK*
|
"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
|
|