The Registry of Toxic Effects of Chemical Substances

D - Glucose

RTECS #: LZ6600000

CAS #: 50-99-7

UPDATE: May 2005 MW: 180.18 MF: C6H12O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Anhydrous dextrose
  2. Cartose
  3. Cerelose
  4. Corn sugar
  5. D - Glucose, anhydrous
  6. Dextropur
  7. Dextrose
  8. Dextrose, anhydrous
  1. Dextrosol
  2. Glucolin
  3. Glucose
  4. Glucose liquid
  5. Glucose, anhydrous
  6. Grape sugar
  7. Sirup
  8. Sugar, grape


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human other cell types 30 mmol/L JCINAO 77,322,1986
DNA damage human other cell types 225 mmol/L/5 day MUREAV 480-481,371,2001
DNA damage human other cell types 315 mmol/L/7 day MUREAV 480-481,371,2001
DNA damage other microorganisms 150 mmol/L PNASA6 81,105,1984
mutation in microorganisms Salmonella typhimurium 25 mg/plate (+enzymatic activation step) NARHAD 12,2127,1984
mutation in mammalian somatic cells mouse lymphocyte 179 mmol/L MUTAEX 3,193,1988
other mutation test systems other microorganisms 1 mole/L ARMKA7 91,305,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
hamster 		lowest published toxic dose: 20 gm/kg (6-8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 33,74C,1986
intraperitoneal
rat 		lowest published toxic dose: 300 gm/kg (30 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina 		OYYAA2 6,251,1972
intravenous
woman 		lowest published toxic dose: 2 gm/kg (39 week pregnant) Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus 		BJOGAS 89,27,1982
intravenous
woman 		lowest published toxic dose: 1,057 µg/kg (39 week pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system BJOGAS 91,1014,1984
intravenous
woman 		lowest published toxic dose: 1,300 mg/kg (39 week pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral 		JPEMAO 16,217,1988
multiple
hamster 		lowest published toxic dose: 20 gm/kg (6-8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 44,193,1991
multiple
hamster 		lowest published toxic dose: 20 mg/kg (6-8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Urogenital system 		TJADAB 44,193,1991
oral
woman 		lowest published toxic dose: 2 gm/kg (28 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities 		NEJMAG 315,989,1986
subcutaneous
hamster 		lowest published toxic dose: 20 gm/kg (6-8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 33,74C,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 15,400 gm/kg/22 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		GANNA2 30,419,1936


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 18 gm/kg N/R PSEBAA 35,98,1936
intravenous
mouse 		lethal dose (50 percent kill): 9 gm/kg N/R ARZNAD 18,666,1968
intravenous
rabbit 		lowest published lethal dose: 12 gm/kg N/R HBTXAC 1,150,1955
oral
dog 		lowest published lethal dose: 8 gm/kg N/R HBTXAC 1,150,1955
oral
rat 		lethal dose (50 percent kill): 25,800 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea 		85AIAL -,39,1973
oral
rabbit 		lowest published lethal dose: 20 gm/kg N/R HBTXAC 1,150,1955


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
domestic animal 		lowest published toxic dose: 4.4 gm/kg/120 hour- continuous Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		REPRD* 124,721,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 560,101,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81836;
Number of Industries 117;
Total Number of Facilities 16,738;
Number of Occupations 90;
Total Number of Employees Exposed 136,870
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81836;
Number of Industries 86;
Total Number of Facilities 11,017;
Number of Occupations 102;
Total Number of Employees Exposed 363,666;
Total Number of Female Employees Exposed 186,490


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85AIAL "Toxicity of Pure Foods," Boyd, E.M., Cleveland, OH, CRC Press, 1973
ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.) V.1-94, 1930-73. For publisher information, see AMICCW.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JPEMAO Journal of Perinatal Medicine. (Walter de Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.1- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NARHAD Nucleic Acids Research. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1974-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
REPRD* Reproduction: the official journal of the Society for the Study of Fertility (Cambridge, England: Society for Reproduction and Fertility) V.121- 2001-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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