RTECS:LW7525000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Gallic acid

RTECS #: LW7525000

CAS #: 149-91-7

UPDATE: February 2005 MW: 170.13 MF: C₇H₆O₅

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

3,4,5 - Trihydroxybenzoic acid

Benzoic acid, 3,4,5 - trihydroxy -

Kyselina 3,4,5 - trihydroxybenzoova (Czech)

Kyselina gallova (Czech)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis hamster ovary 50 mg/L CALEDQ 14,251,1981
cytogenetic analysis intraperitoneal
mouse 100 痠ol/kg IJMRAQ 59,1442,1971
DNA damage hamster other cell types 15 痠ol/L/1 hour MUREAV 539,127,2003
DNA damage non-mammalian species other cell types 10 痠ol/L/1 hour MUREAV 539,19,2003
DNA damage salmon embryo 10 痠ol/L/1 hour MUREAV 563,89,2004
mutation in microorganisms Escherichia coli 750 痢/plate (-enzymatic activation step) MUREAV 467,41,2000
mutation in microorganisms Salmonella typhimurium 100 痢/plate (+/-enzymatic activation step) ABCHA6 45,327,1981
gene conversion and mitotic recombination Saccharomyes cerevisiae 100 mg/L MUREAV 135,109,1984
sister chromatid exchange hamster ovary 0.5 mmol/L/3 hour MUREAV 498,117,2001

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
subcutaneous
rat lowest published toxic dose: 5 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes ENDOAO 57,466,1955

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 4,300 mg/kg N/R PHTOEH 64,247,1989
intravenous
mouse lethal dose (50 percent kill): 320 mg/kg N/R CSLNX* NX#02597
oral
rabbit lethal dose (50 percent kill): 5 gm/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes AJVRAH 23,1264,1962
subcutaneous
rat lowest published lethal dose: 5 gm/kg N/R JAFCAU 17,497,1969

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 28 gm/kg/28 day- continuous Endocrine: Changes in spleen weight FCTOD7 39,919,2001
oral
rat lowest published toxic dose: 32.5 gm/kg/13 week- continuous Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Changes in: P FCTOD7 39,1063,2001
oral
rat lowest published toxic dose: 91 gm/kg/13 week- continuous Liver: Changes in liver weight

Liver: Other changes FCTOD7 39,1063,2001
oral
rat lowest published toxic dose: 100 gm/kg/13 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: P FCTOD7 39,1063,2001
oral
rat lowest published toxic dose: 291 gm/kg/13 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen FCTOD7 39,1063,2001
oral
rat lowest published toxic dose: 273 gm/kg/13 week- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 39,1063,2001

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84280;
Number of Industries 21;
Total Number of Facilities 549;
Number of Occupations 10;
Total Number of Employees Exposed 2,520
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84280;
Number of Industries 14;
Total Number of Facilities 294;
Number of Occupations 8;
Total Number of Employees Exposed 2,184;
Total Number of Female Employees Exposed 252

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-

Used in ink dyes, as a photographic developer and in tanning

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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