The Registry of Toxic Effects of Chemical Substances

Furfuryl alcohol

RTECS #: LU9100000

CAS #: 98-00-0

UPDATE: February 2005 MW: 98.11 MF: C5H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Furancarbinol
  2. 2 - Furanmethanol
  3. Furfural alcohol
  4. Furfuralcohol
  5. 2 - Furfurylalkohol (Czech)
  6. Furyl alcohol
  7. alpha - Furylcarbinol
  1. 2 - Furylcarbinol
  2. Methanol, (2 - furyl) -
  3. NCI - C56224
  4. Furfuryl alcohol (ACGIH:OSHA)
  5. 2 - Furylmethanol
  6. 2 - Hydroxymethylfuran


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,787,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 2,500 µmol/L CALEDQ 13,89,1981
cytogenetic analysis inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis inhalation
rat 		0.5 ppb EMMUEG 39,69,2002
DNA repair Bacillus subtilis 2 mg/disc DFSCDX 13,353,1986
specific locus test inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test inhalation
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 32 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NTPTR* NTP-TR-482,1999
inhalation
mouse 		lowest published toxic concentration: 2,016 mg/kg/105 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NTIS** PB99-151482
inhalation
rat 		lowest published toxic concentration: 32 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		NTPTR* NTP-TR-482,1999
inhalation
rat 		lowest published toxic concentration: 1,008 mg/kg/105 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		NTIS** PB99-151482


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 597 ppm/6 hour N/R 34ZIAG -,280,1969
inhalation
rat 		lethal concentration (50 percent kill): 233 ppm/4 hour N/R AIHAAP 19,91,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 650 mg/kg N/R NPIRI* 1,64,1974
intravenous
rabbit 		lethal dose (50 percent kill): 650 mg/kg N/R FEPRA7 8,294,1949
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 360 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 160 mg/kg Tumorigenic: Active as anti-cancer agent BIJOAK 34,1196,1940
oral
rat 		lethal dose (50 percent kill): 177 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		GTPZAB 25(9),52,1981
subcutaneous
rat 		lethal dose (50 percent kill): 85 mg/kg Behavioral: Convulsions or effect on seizure threshold 34ZIAG -,280,1969
skin
rat 		lethal dose (50 percent kill): 3,825 mg/kg N/R GTPZAB 25(9),52,1981
skin
rabbit 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Convulsions or effect on seizure threshold 34ZIAG -,280,1969
unreported route
mouse 		lethal dose (50 percent kill): 338 mg/kg N/R GISAAA 55(6),73,1990
unreported route
rat 		lethal dose (50 percent kill): 460 mg/kg N/R GISAAA 55(6),73,1990
unreported route
rabbit 		lethal dose (50 percent kill): 632 mg/kg N/R GISAAA 55(6),73,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 22 mg/m3/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GTPZAB 25(9),52,1981
inhalation
mouse 		lowest published toxic concentration: 16 ppm/6 hour/16 day- intermittent Olfaction: Other olfaction effects NTPTR* NTP-TR-482,1999
inhalation
mouse 		lowest published toxic concentration: 2 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects NTPTR* NTP-TR-482,1999
inhalation
rat 		lowest published toxic concentration: 250 mg/m3/2 week- intermittent Olfaction: Other olfaction effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOPADD 19,617,1991
inhalation
rat 		lowest published toxic concentration: 50 ppm/6 hour/16 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		ENVRAL 31,420,1983
inhalation
rat 		lowest published toxic concentration: 16 ppm/6 hour/16 day- intermittent Olfaction: Other olfaction effects NTPTR* NTP-TR-482,1999
inhalation
rat 		lowest published toxic concentration: 2 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects NTPTR* NTP-TR-482,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm (skin);short term exposure limit 15 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 15 ppm (skin) DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (20 mg/m3) (skin) DTLWS* 3,19,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (40 mg/m3), short term exposure limit 15 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (40 mg/m3), short term exposure limit 15 ppm, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (40 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 8 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 5 ppm, short term exposure limit 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 5 ppm (20 mg/m3), KTV 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (40 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (20 mg/m3), short term exposure limit 15 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 15 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 15 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FURFURYL ALCOHOL-air time-weighted average 10 ppm (Sk);
short term exposure limit 15 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 34370;
Number of Industries 29;
Total Number of Facilities 2,939;
Number of Occupations 38;
Total Number of Employees Exposed 11,577
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 34370;
Number of Industries 46;
Total Number of Facilities 2,827;
Number of Occupations 63;
Total Number of Employees Exposed 77,710;
Total Number of Female Employees Exposed 14,624


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a starting monomer in the production of furan resins and used to produce THFA
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Furfuryl alcohol, 2505
NTP Carcinogenesis Studies (inhalation):some evidence:mouse, rat NTPTR* NTP-TR-482,1999
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-

Used as a starting monomer in the production of furan resins and used to produce THFA

NIOSH PROFILE (FURFURYL ALCOHOL), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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