The Registry of Toxic Effects of Chemical Substances

2 (3H) - Furanone, dihydro -

RTECS #: LU3500000

CAS #: 96-48-0

UPDATE: February 2005 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Butanolide
  2. 1,4 - Butanolide
  3. 2 - Oxolanone
  4. 4 - Butanolide
  5. 4 - Butyrolactone
  6. 4 - Deoxytetronic acid
  7. 4 - Hydroxybutanoic acid lactone
  8. 4 - Hydroxybutanoic acid, gamma - lactone
  9. 4 - Hydroxybutyric acid lactone
  10. 4 - Hydroxybutyric acid, gamma - lactone
  11. Agrisynth BLO
  12. Butyric acid lactone
  13. Butyric acid, 4 - hydroxy - , gamma - lactone
  14. Butyrolactone
  1. Butyryl lactone
  2. Butyrylactone
  3. C - 1070
  4. Dihydro - 2 (3H) - furanone
  5. NCI - C55878
  6. Tetrahydro - 2 - furanone
  7. gamma - 6480
  8. gamma - BL
  9. gamma - Butyrolactone
  10. gamma - Hydroxybutyric acid cyclic ester
  11. gamma - Hydroxybutyric acid lactone
  12. gamma - Hydroxybutyrolactone
  13. gamma - butyrolactone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 µL severe NTIS** OTS0536954


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 2,580 mg/L EMMUEG 13,60,1989
cytogenetic analysis oral
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis oral
rat 		0.5 ppb EMMUEG 39,69,2002
DNA damage Bacillus subtilis 20 µL/disc PMRSDJ 1,175,1981
morphological transform hamster kidney 25 mg/L PMRSDJ 1,638,1981
sister chromatid exchange hamster ovary 4,940 mg/L EMMUEG 13,60,1989
specific locus test oral
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test oral
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 25 gm/kg (20 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ARANDR 10,239,1983
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) PHTOEH 62,57,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 191 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors 		NTPTR* NTP-TR-406,1992
oral
mouse 		lowest published toxic dose: 134,930 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors 		NTIS** PB92-189323
skin
mouse 		lowest published toxic dose: 50 gm/kg/42 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 31,41,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >5,100 mg/m3/4 hour N/R NTIS** OTS0534527
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,100 mg/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes 		AITEAT 13,70,1965
intraperitoneal
rat 		lethal dose (50 percent kill): 1 gm/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes 		AITEAT 13,70,1965
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg Behavioral: Sleep TOSCF2 73,270,2003
intravenous
rabbit 		lowest published lethal dose: 500 mg/kg N/R AITEAT 13,70,1965
oral
mouse 		lethal dose (50 percent kill): 1,460 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		GISAAA 64(2),3,1999
oral
rat 		lethal dose (50 percent kill): 1,540 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		GTPZAB 31(1),49,1987
parenteral
mouse 		lowest published lethal dose: 1,600 mg/kg N/R CBCCT* 7,687,1955
skin
guinea pig 		lethal dose (50 percent kill): >5 gm/kg N/R GAFCC*


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5,030 µg/m3/24 hour/17 week- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 64(2),3,1999
oral
mouse 		lowest published toxic dose: 68 gm/kg/16 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-406,1992
oral
mouse 		lowest published toxic dose: 134,930 mg/kg/103 week- intermittent Liver: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB92-189323
oral
rat 		lowest published toxic dose: 9,600 mg/kg/30 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		GISAAA 64(2),3,1999
oral
rat 		lowest published toxic dose: 9,600 mg/kg/16 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-406,1992
oral
rat 		lowest published toxic dose: 40,950 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-406,1992
oral
rat 		lowest published toxic dose: 115,875 mg/kg/103 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB92-189323


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 11,231,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal No Evidence IMEMDT 71,367,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 11,231,1976
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,367,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,367,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1130;
Number of Industries 12;
Total Number of Facilities 1,476;
Number of Occupations 18;
Total Number of Employees Exposed 5,155
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1130;
Number of Industries 38;
Total Number of Facilities 4,447;
Number of Occupations 42;
Total Number of Employees Exposed 44,126;
Total Number of Female Employees Exposed 11,013


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate in the production of 2-PYRROLIDONE, and as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat


REFERENCES:

CODEN
REFERENCE
AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962-
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used as a chemical intermediate in the production of 2-PYRROLIDONE, and as a solvent

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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