The Registry of Toxic Effects of Chemical Substances
2 - Furanmethanol, tetrahydro - |
UPDATE: December 2000 | MW: 102.15 | MF: C5H10O2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 20 mg/24 hour | moderate | 85JCAE -,786,1986 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 500 ppm/6 hour (13 week male) |
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | NTIS** OTS0557931 |
skin rat | lowest published toxic dose: 65 gm/kg (13 week male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | NTIS** OTS0557932 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal guinea pig | lethal dose (50 percent kill): 400 mg/kg | N/R | 38MKAJ 2C,4658,1982 |
intraperitoneal rat | lethal dose (50 percent kill): 400 mg/kg | N/R | 38MKAJ 2C,4658,1982 |
intravenous rabbit | lethal dose (50 percent kill): 725 mg/kg | N/R | FEPRA7 8,294,1949 |
oral guinea pig | lethal dose (50 percent kill): 800 mg/kg | N/R | 38MKAJ 2C,4658,1982 |
oral mouse | lethal dose (50 percent kill): 2,300 mg/kg | Behavioral: General anesthetic | HYSAAV 32(2),273,1967 |
oral rat | lethal dose (50 percent kill): 1,600 mg/kg | N/R | 38MKAJ 2C,4658,1982 |
skin guinea pig | lethal dose (50 percent kill): 5 gm/kg | N/R | 38MKAJ 2C,4658,1982 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 500 ppm/6 hour/13 week- intermittent |
Behavioral: Convulsions or effect on seizure threshold Blood: Changes in platelet count Related to Chronic Data: Changes in prostate weight | NTIS** OTS0557931 |
oral rat | lowest published toxic dose: 54 gm/kg/90 day- continuous |
Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | NTIS** OTS0535211 |
oral rat | lowest published toxic dose: 1,500 mg/kg/5 day- intermittent |
Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0535211-2 |
skin rat | lowest published toxic dose: 65 gm/kg/13 week- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0556424 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 83085; Number of Industries 9; Total Number of Facilities 1,654; Number of Occupations 9; Total Number of Employees Exposed 2,169 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 83085![]() Number of Industries 41; Total Number of Facilities 5,004; Number of Occupations 33; Total Number of Employees Exposed 81,543; Total Number of Female Employees Exposed 48,075 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as biocide carrier in industrial cleaners, coating removers, chemical intermediate | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
38MKAJ | "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. |
85JCAE | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 |
FEPRA7 | Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. |
HYSAAV | Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |