The Registry of Toxic Effects of Chemical Substances

Furan

RTECS #: LT8524000

CAS #: 110-00-9

UPDATE: May 2005 MW: 68.08 MF: C4H4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Axole
  2. Divinylene oxide
  3. 1,4 - Epoxy - 1,3 - butadiene
  4. NCI - C56202
  5. RCRA waste number U124
  1. Furfuran
  2. Oxacyclopentadiene
  3. Oxole
  4. Tetrole


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 184 mmol/L CALEDQ 13,89,1981
DNA repair Bacillus subtilis 3,500 µg/disc DFSCDX 13,353,1986
mutation in microorganisms Salmonella typhimurium 825 nmol/plate (+/-enzymatic activation step) DFSCDX 13,353,1986
mutation in mammalian somatic cells mouse lymphocyte 1,139 mg/L EMMUEG 12,85,1988
sister chromatid exchange hamster lung 3 µmol/L/32 hour MUREAV 580,41,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3,900 mg/kg (13 week male/13 week prior to copulation) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Maternal effects: Ovaries, fallopian tubes 		NTPTR* NTP-TR-402,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 4,160 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-402,1993
oral
mouse 		lowest published toxic dose: 4,120 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB93-228419
oral
rat 		lowest published toxic dose: 1,040 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Liver: Angiosarcoma 		NTPTR* NTP-TR-402,1993
oral
rat 		lowest published toxic dose: 1,950 mg/kg/36 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Liver: Angiosarcoma 		NTIS** PB93-228419
oral
rat 		lowest published toxic dose: 1,030 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Liver: Angiosarcoma 		NTIS** PB93-228419
oral
rat 		lowest published toxic dose: 1,030 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB93-228419
oral
rat 		lowest published toxic dose: 2,060 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NTIS** PB93-228419
oral
rat 		lowest published toxic dose: 1,080 mg/kg/36 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Angiosarcoma

Tumorigenic: Increased incidence of tumors in susceptible strains 		TXCYAC 192,71,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 120 mg/m3/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		AIHAAP 40,310,1979
inhalation
rat 		lethal concentration (50 percent kill): 3,398 ppm/1 hour Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		HAZL** HLA468-102,1987
intraperitoneal
mouse 		lethal dose (50 percent kill): 7 mg/kg N/R AIHAAP 40,310,1979
intraperitoneal
rat 		lethal dose (50 percent kill): 5,200 µg/kg N/R AIHAAP 40,310,1979
intravenous
dog 		lowest published lethal dose: 140 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Hemorrhage 		JPETAB 26,281,1926
oral
dog 		lowest published lethal dose: 234 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting

Blood: Hemorrhage 		JPETAB 26,281,1926
oral
rabbit 		lowest published lethal dose: 234 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting

Blood: Hemorrhage 		JPETAB 26,281,1926


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 mg/m3/4 hour/60 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 9,106,1967
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/2 hour/9 week- intermittent Liver: Jaundice, other or unclassified

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 10,35,1968
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/4 hour/26 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Vascular: BP lowering not characterized in autonomic section 		TPKVAL 10,35,1968
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/2 hour/30 day- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 9,106,1967
oral
mouse 		lowest published toxic dose: 1,950 mg/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-402,1993
oral
mouse 		lowest published toxic dose: 2,730 mg/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-402,1993
oral
rat 		lowest published toxic dose: 600 mg/kg/2 week- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AJPAA4 145,375,1994
oral
rat 		lowest published toxic dose: 240 mg/kg/16 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-402,1993
oral
rat 		lowest published toxic dose: 3,900 mg/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Changes in thymus weight 		NTPTR* NTP-TR-402,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 63,393,1995
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,393,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 63,393,1995
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 34185;
Number of Industries 2;
Total Number of Facilities 25;
Number of Occupations 3;
Total Number of Employees Exposed 244
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 34185;
Number of Industries 2;
Total Number of Facilities 14;
Number of Occupations 2;
Total Number of Employees Exposed 35;
Total Number of Female Employees Exposed 7


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in production of herbicides and pharmaceuticals
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
HAZL** Hazelton Laboratories, Reports. (Falls Church, VA)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as intermediate in production of herbicides and pharmaceuticals

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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