The Registry of Toxic Effects of Chemical Substances

Formamide, 1,1' - azobis -

RTECS #: LQ1040000

CAS #: 123-77-3

UPDATE: November 2004 MW: 116.10 MF: C2H4N4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1' - Azobis (formamide)
  2. 1,1' - Azobiscarbamide
  3. Azobiscarbonamide
  4. Azobiscarboxamide
  5. Azodicarbamide
  6. Azodicarboamide
  7. Azodicarbonamide
  8. Azodicarboxamide
  9. Azodicarboxylic acid diamide
  10. ChKhz 21
  11. ChKhz 21R
  12. delta (1,1') - Biurea
  13. Celosen AZ
  14. Diazenedicarboxamide
  15. Genitron AC 2
  16. Genitron AC 4
  1. Kempore
  2. Kempore 125
  3. Kempore R 125
  4. Lucel ADA
  5. NCI - C55981
  6. Genitron AC
  7. Nitropore
  8. Pinhole AK 2
  9. Porofor 505
  10. Porofor adc/R
  11. Porofor Chkhz 21
  12. Porofor Chkhz 21R
  13. Unifoam AZ
  14. Uniform AZ
  15. Yunihomu AZ


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) ENMUDM 8(Suppl 7),1,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 440 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair 		ATDAEI 15(Suppl 1),S66,1996
oral
rat 		lethal dose (50 percent kill): >6,400 mg/kg N/R AIHAAP 48,127,1987
skin
rat 		lethal dose (50 percent kill): >500 mg/kg N/R ATDAEI 15(Suppl 1),S66,1996


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 217 mg/m3/6 hour/2 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 15,308,1990
inhalation
mouse 		lowest published toxic concentration: 204 mg/m3/6 hour/13 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 15,308,1990
inhalation
rat 		lowest published toxic concentration: 207 mg/m3/6 hour/2 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 15,308,1990
inhalation
rat 		lowest published toxic concentration: 204 mg/m3/6 hour/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) FAATDF 15,308,1990
intraperitoneal
rat 		lowest published toxic dose: 252 mg/kg/1 week- intermittent Kidney, Ureter, and Bladder: Hematuria

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JCEMAZ 32,659,1971
oral
rat 		lowest published toxic dose: 42 gm/kg/10 day- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight 		JCEMAZ 32,659,1971
oral
rat 		lowest published toxic dose: 233 gm/kg/4 week- continuous Endocrine: Evidence of thyroid hypofunction JCEMAZ 32,659,1971


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG intermittent mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81713;
Number of Industries 32;
Total Number of Facilities 1,753;
Number of Occupations 60;
Total Number of Employees Exposed 43,147
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81713;
Number of Industries 18;
Total Number of Facilities 1,210;
Number of Occupations 29;
Total Number of Employees Exposed 42,296;
Total Number of Female Employees Exposed 17,091


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in dynamic foaming processes, and as a blowing agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952-

Used in dynamic foaming processes, and as a blowing agent

RTECS Compound Description:
   Mutagen

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