The Registry of Toxic Effects of Chemical Substances

Formic acid, ethyl ester

RTECS #: LQ8400000

CAS #: 109-94-4

UPDATE: November 2004 MW: 74.09 MF: C3H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aethylformiat (German)
  2. Areginal
  3. Ethyl formate
  4. Ethyl formate (ACGIH:OSHA)
  5. Ethyl formic ester
  6. Ethyl methanoate
  1. Ethyle (formiate d') (French)
  2. Ethylester kyseliny mravenci (Czech)
  3. Ethylformiaat (Dutch)
  4. Etile (formiato di) (Italian)
  5. Formic ether
  6. Mrowczan etylu (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		460 mg open irritation test mild UCDS** 4/10/1968


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 110 gm/kg/9 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		BJCAAI 9,177,1955


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 8,000 ppm/4 hour N/R AMIHBC 10,61,1954
oral
guinea pig 		lethal dose (50 percent kill): 1,110 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Gastritis 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 1,850 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		FCTXAV 2,327,1964
oral
rabbit 		lethal dose (50 percent kill): 2,075 mg/kg N/R IMSUAI 41,31,1972
subcutaneous
rabbit 		lowest published lethal dose: 1 gm/kg N/R FCTXAV 16,737,1978
skin
rabbit 		lethal dose (50 percent kill): >20 mL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rabbit 		lowest published toxic dose: 619 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Proteinuria

Blood: Other changes 		FAONAU 44A,1,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AMIHAB 20,517,1959


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (300 mg/m3) DTLVS* 3,107,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (303 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 450 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 300 mg/m3, 2003
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (308 mg/m3), STWL 150 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL FORMATE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 32610;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 1;
Total Number of Employees Exposed 124
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 32610;
Number of Industries 6;
Total Number of Facilities 99;
Number of Occupations 19;
Total Number of Employees Exposed 8,151;
Total Number of Female Employees Exposed 1,169


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, emulsifier, food and feed additive, flavor, packaging material
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl formate, 1452


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a solvent, emulsifier, food and feed additive, flavor, packaging material

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Primary Irritant

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