The Registry of Toxic Effects of Chemical Substances

Formic acid, chloro - , isopropyl ester

RTECS #: LQ6475000

CAS #: 108-23-6

UPDATE: November 2004 MW: 122.56 MF: C4H7ClO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Chloroformic acid isopropyl ester
  2. Carbonochloride acid, 1 - methylethyl ester
  3. Isopropyl chlorocarbonate
  1. Isopropyl chloromethanoate
  2. Isopropylester kyseliny chlormravenci (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg severe IHFCAY 6,1,1967
skin
rabbit 		500 mg severe IHFCAY 6,1,1967


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 200 ppm/5 hour Lung, Thorax, or Respiration: Dyspnea BJIMAG 27,1,1970
oral
mouse 		lethal dose (50 percent kill): 178 mg/kg N/R 37ASAA 4,758,1978
oral
rat 		lethal dose (50 percent kill): 1,070 mg/kg N/R IHFCAY 6,1,1967
skin
mouse 		lethal dose (50 percent kill): 12 mg/kg N/R 37ASAA 4,758,1978
skin
rabbit 		lethal dose (50 percent kill): 11,300 mg/kg N/R IHFCAY 6,1,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 50 ppm/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BJIMAG 27,1,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (5.1 mg/m3), SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69.

Used as reactive intermediate to pesticides, veterinary medicine, polymerization initiators

RTECS Compound Description:
   Primary Irritant

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