The Registry of Toxic Effects of Chemical Substances
Formic acid |
UPDATE: November 2004 | MW: 46.03 | MF: CH2O2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 122 mg | severe | UCDS** 8/5/1968 |
skin rabbit | 610 mg open irritation test | mild | UCDS** 8/5/1968 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster ovary | 10 mmol/L | MUREAV 240,195,1990 |
cytogenetic analysis | non-mammalian species other cell types | 100 mmol/L | CAANAT 56,712,1972 |
mutation in microorganisms | Escherichia coli | 70 ppm/3 hour (-enzymatic activation step) | AMNTA4 85,119,1951 |
other mutation test systems | non-mammalian species other cell types | 100 mmol/L | CAANAT 56,712,1972 |
phage inhibition capacity | Escherichia coli | 100 mmol/L | MDMIAZ 31,11,1979 |
sister chromatid exchange | human lymphocyte | 10 mmol/L | MUREAV 279,75,1992 |
sex chromosome loss and nondisjunction |
inhalation Drosophila melanogaster | 1,000 ppm/24 hour | THAGA6 39,330,1969 |
sex chromosome loss and nondisjunction |
oral Drosophila melanogaster | 1,000 ppm | THAGA6 39,330,1969 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation man | lowest published toxic concentration: 7,300 痢/m3/8 hour | Kidney, Ureter, and Bladder: Other changes in urine composition | ARTODN 66,522,1992 |
inhalation mouse | lethal concentration (50 percent kill): 6,200 mg/m3/15 minute |
Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | GTPZAB 23(12),49,1979 |
inhalation rat | lethal concentration (50 percent kill): 15 gm/m3/15 minute |
Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | GTPZAB 23(12),49,1979 |
intraperitoneal mouse | lethal dose (50 percent kill): 940 mg/kg | N/R | IGIBA5 11,507,1962 |
intravenous dog | lowest published lethal dose: 3 gm/kg | N/R | HBTXAC 1,146,1955 |
intravenous mouse | lethal dose (50 percent kill): 145 mg/kg | N/R | ZERNAL 9,332,1969 |
intravenous rabbit | lowest published lethal dose: 239 mg/kg | N/R | HBTXAC 1,146,1955 |
oral dog | lethal dose (50 percent kill): 4 gm/kg | N/R | AMIHAB 20,517,1959 |
oral mouse | lethal dose (50 percent kill): 700 mg/kg |
Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | GTPZAB 23(12),49,1979 |
oral rat | lethal dose (50 percent kill): 1,100 mg/kg |
Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | GTPZAB 23(12),49,1979 |
oral woman | lowest published toxic dose: 2,200 mg/kg |
Lung, Thorax, or Respiration: Sputum Kidney, Ureter, and Bladder: Hematuria Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | JTCTDW 32,199,1994 |
oral woman | lowest published lethal dose: 2,440 痢/kg |
Vascular: Shock Blood: Other hemolysis with or without anemia Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | AJEMEN 7,286,1989 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mouse | lowest published toxic concentration: 500 ppm/6 hour/12 day- intermittent |
Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NIH-92-3342 |
inhalation mouse | lowest published toxic concentration: 64 ppm/6 hour/13 week- intermittent |
Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NIH-92-3342 |
inhalation rat | lowest published toxic concentration: 500 ppm/6 hour/12 day- intermittent |
Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NIH-92-3342 |
inhalation rat | lowest published toxic concentration: 64 ppm/6 hour/13 week- intermittent |
Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | NTPTR* NIH-92-3342 |
inhalation rat | lowest published toxic concentration: 50 mg/m3/16 week- intermittent |
Brain and Coverings: Recordings from specific areas of CNS Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Proteinuria | GTPZAB 19(12),49,1975 |
oral rat | lowest published toxic dose: 22,680 mg/kg/9 week- continuous |
Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JPETAB 16,463,1921 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 5 ppm | DTLVS* TLV/BEI,2002 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 5 ppm;short term exposure limit 10 ppm | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | short term exposure limit 10 ppm | DTLVS* TLV/BEI,2002 |
TOXICOLOGY REVIEW |
| REPTED 17,349,2003 |
TOXICOLOGY REVIEW |
| ARTODN 39,299,1978 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 5 ppm (9 mg/m3) | DTLVS* 3,119,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 5 ppm (9 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 5 ppm (9 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 5 ppm (9 mg/m3) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 5 ppm (9 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - ARAB Republic of Egypt | time-weighted average 5 ppm (9 mg/m3), JAN1993 | |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 5 ppm (9 mg/m3), JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 5 ppm (9 mg/m3), JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 5 ppm (9.4 mg/m3), JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 5 ppm (9 mg/m3), JAN1999 | |
Occupational Exposure Limit - FRANCE | VLE 5 ppm (9 mg/m3), JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 5 ppm (9 mg/m3), JAN1999 | |
Occupational Exposure Limit - HUNGARY | time-weighted average 5 mg/m3, short term exposure limit 8 mg/m3, JAN1993 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 9 mg/m3, 2003 | |
Occupational Exposure Limit - NORWAY | time-weighted average 5 ppm (9 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 5 ppm (9 mg/m3), JAN1993 | |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 15 mg/m3, JAN1999 | |
Occupational Exposure Limit - RUSSIA | time-weighted average 5 ppm, short term exposure limit 1 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit - SWEDEN | time-weighted average 3 ppm (5 mg/m3), short term exposure limit 15 ppm (45 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 5 ppm (9 mg/m3), short term exposure limit 10 ppm (18 mg/m3), JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 5 ppm (9.6 mg/m3), SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; short term exposure limit 10 ppm | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 10 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FORMIC ACID-air | 10 hour time-weighted average 5 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 33720; Number of Industries 59; Total Number of Facilities 3,537; Number of Occupations 48; Total Number of Employees Exposed 34,087 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 33720![]() Number of Industries 95; Total Number of Facilities 6,368; Number of Occupations 77; Total Number of Employees Exposed 158,933; Total Number of Female Employees Exposed 37,338 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used in pharmaceuticals, textile dyeing and finishing and leather tanning | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Formic acid, 2011 | |
NTP Toxicity studies, RPT# TOX-19, October 2000 | |
OSHA ANALYTICAL METHOD #ID-112 |
REFERENCES: | |
CODEN |
REFERENCE |
AJEMEN | American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- |
AMIHAB | AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. |
AMNTA4 | American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867- |
ARTODN | Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- |
CAANAT | Comptes Rendus de l'Association des Anatomistes. (Nancy, France) V.1-56, 1899-1972. For publisher information, see ANOBAU. |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
HBTXAC | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 |
IGIBA5 | Igiena. (Bucharest, Romania) V.5-23, 1956-74(?). For publisher information, see RABIDH. |
JPETAB | Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- |
JTCTDW | Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- |
MDMIAZ | Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTPTR* | National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- |
REPTED | Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- |
THAGA6 | Theoretical & Applied Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.38- 1968- |
UCDS** | Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) |
ZERNAL | Zeitschrift fuer Ernaehrungswissenschaft. (Dr. Dietrich Steinkopff Verlag, Postfach 111008, D-6100 Darmstadt 11, Fed. Rep. Ger.) V.1- 1960- |