The Registry of Toxic Effects of Chemical Substances

Formamidine, N' - (4 - chloro - o - tolyl) - N,N - dimethyl - , hydrochloride

RTECS #: LQ4550000

CAS #: 19750-95-9

UPDATE: August 2003 MW: 233.16 MF: C10H13ClN2•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. CGA - 72651
  2. Chlordimeform hydrochloride
  3. Chlorophenamidine hydrochloride
  4. N' - (4 - Chloro - o - tolyl) - N,N - dimethylformamidine, hydrochloride
  5. N,N - Dimethyl - N' - (2 - methyl - 4 - chlorophenyl) - formamidine, hydrochloride
  6. ENT 27567
  7. EP 333
  8. Methanimidamide, N' - (4 - chloro - 2 - methylphenyl) - N,N - dimethyl - , monohydrochloride (9CI)
  1. Spanone
  2. Spanone monohydrochloride
  3. Fundal SP
  4. Galecron monohydrochloride
  5. Morton EP 333
  6. Nor - AM EP 333
  7. NSC 195102


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild CIGET*


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 85,500 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		PCBPBS 9,148,1978
oral
mouse 		lethal dose (50 percent kill): 290 mg/kg N/R BESAAT 15,103,1969
oral
rat 		lethal dose (50 percent kill): 225 mg/kg N/R SPEADM 78-1,22,1978
oral
rabbit 		lethal dose (50 percent kill): 625 mg/kg N/R BESAAT 15,103,1969
skin
rat 		lethal dose (50 percent kill): 4 gm/kg N/R SPEADM 78-1,22,1978
skin
rabbit 		lethal dose (50 percent kill): >4 gm/kg N/R SPEADM 78-1,22,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 3,600 mg/kg/60 day- continuous Liver: Change in gall bladder structure or function

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes 		NTIS** OTS0543161
oral
rat 		lowest published toxic dose: 21,600 mg/kg/60 day- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0543167


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,96,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)

RTECS Compound Description:
   Agricultural Chemical
   Primary Irritant

ALT CAS #: 23167-93-3
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