The Registry of Toxic Effects of Chemical Substances

Formamide, N - methyl -

RTECS #: LQ3000000

CAS #: 123-39-7

UPDATE: February 2005 MW: 59.08 MF: C2H5NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. EK 7011
  2. Methylformamide
  3. N - Methylformamide
  1. Monomethylformamide
  2. NSC 3051
  3. X 188


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg N/R TXAPA9 39,129,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination Saccharomyes cerevisiae 500 mmol/L/3 hour EMMUEG 36,97,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 700 mg/kg (7-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities 		85DJA5 -,95,1971
oral
mouse 		lowest published toxic dose: 200 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ARZNAD 17,610,1967
oral
mouse 		lowest published toxic dose: 400 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARZNAD 17,610,1967
oral
rat 		lowest published toxic dose: 1 gm/kg (7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities 		85DJA5 -,95,1971
oral
rat 		lowest published toxic dose: 750 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FAATDF 27,239,1995
oral
rat 		lowest published toxic dose: 750 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FAATDF 27,239,1995
oral
rabbit 		lowest published toxic dose: 650 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ARZNAD 30,1557,1980
oral
rabbit 		lowest published toxic dose: 650 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		ARZNAD 30,1557,1980
oral
rabbit 		lowest published toxic dose: 650 mg/kg (6-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system 		FAATDF 27,239,1995
oral
rabbit 		lowest published toxic dose: 650 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system 		FAATDF 27,239,1995
subcutaneous
mouse 		lowest published toxic dose: 70 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		DABBBA 40,549,1979
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (10 day pregnant) Reproductive: Other developmental abnormalities APEPA2 257,296,1967
skin
mouse 		lowest published toxic dose: 400 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ARZNAD 17,610,1967
skin
mouse 		lowest published toxic dose: 800 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARZNAD 17,610,1967
skin
rat 		lowest published toxic dose: 1,200 mg/kg (12-13 day pregnant) Reproductive: Specific developmental abnormalities: Body wall TXAPA9 41,35,1977
skin
rat 		lowest published toxic dose: 400 mg/kg (12-13 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 41,35,1977
skin
rat 		lowest published toxic dose: 600 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TXAPA9 41,35,1977
skin
rabbit 		lowest published toxic dose: 1,800 mg/kg (8-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TXAPA9 41,35,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): 2,700 mg/kg N/R TXCYAC 34,173,1985
intraperitoneal
mouse 		lethal dose (50 percent kill): 802 mg/kg N/R NCISP* JAN1986
intraperitoneal
rat 		lethal dose (50 percent kill): 3,500 mg/kg N/R JRPFA4 4,219,1962
intravenous
dog 		lethal dose : >568 mg/kg Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** PB82-232158
intravenous
mouse 		lethal dose (50 percent kill): 1,580 mg/kg N/R TXCYAC 34,173,1985
oral
mouse 		lethal dose (50 percent kill): 2,600 mg/kg N/R TXCYAC 34,173,1985
oral
rat 		lethal dose (50 percent kill): 2,700 mg/kg N/R CBINA8 148,1,2004
subcutaneous
mouse 		lethal dose (50 percent kill): 3,100 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease 		DABBBA 40,549,1979
subcutaneous
rat 		lethal dose (50 percent kill): >2,500 mg/kg N/R APEPA2 257,296,1967
unreported route
guinea pig 		lethal dose (50 percent kill): 465 mg/kg Eye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes 		GISAAA 57(2),30,1992
unreported route
mouse 		lethal dose (50 percent kill): 1,175 mg/kg Eye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes 		GISAAA 57(2),30,1992
unreported route
rat 		lethal dose (50 percent kill): 2,400 mg/kg Eye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes 		GISAAA 57(2),30,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FAATDF 14,810,1990
intraperitoneal
mouse 		lowest published toxic dose: 4 gm/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		TXCYAC 34,173,1985
intravenous
dog 		lowest published toxic dose: 662 mg/kg/5 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		NTIS** PB82-232158
intravenous
mouse 		lowest published toxic dose: 5,603 mg/kg/5 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Endocrine: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** PB82-232158
oral
rat 		lowest published toxic dose: 5,460 µg/kg/26 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Changes in: Cl 		GISAAA 57(2),30,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and an antitumour agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971
APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a solvent and an antitumour agent

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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