RTECS:LM6475000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Fluorine

RTECS #: LM6475000

CAS #: 7782-41-4

UPDATE: November 2004 MW: 38.00 MF: F₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Fluor (Dutch, French, German, Polish)

Bifluoriden (Dutch)

Fluorine (ACGIH:OSHA)

Fluorures acide (French)

Fluoruri acidi (Italian)

RCRA waste number P056

Saeure fluoride (German)

Fluoro (Italian)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
dog 68 ppm/1 hour N/R AIHAAP 29,10,1968
eye
human 25 ppm/5 minute mild AIHAAP 29,10,1968
eye
mouse 467 ppm/5 minute mild AIHAAP 29,10,1968
eye
rat 140 ppm/30 minute mild AIHAAP 29,10,1968

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
dog lethal concentration (50 percent kill): 1,120 mg/m³/15 minute Brain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema STGNBT -,234,1999
inhalation
dog lethal concentration (50 percent kill): 1,250 mg/m³/5 minute N/R VCVN5* -,342,1993
inhalation
dog lethal concentration (50 percent kill): 250 mg/m³/60 minute N/R VCVN5* -,342,1993
inhalation
dog lethal concentration : 28 mg/m³ Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough VCVN5* -,342,1993
inhalation
guinea pig lethal concentration (50 percent kill): 170 ppm/1 hour Eye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 29,10,1968
inhalation
guinea pig lethal concentration (50 percent kill): 1,250 mg/m³/5 minute N/R VCVN5* -,342,1993
inhalation
guinea pig lethal concentration (50 percent kill): 250 mg/m³/60 minute N/R VCVN5* -,342,1993
inhalation
guinea pig lowest published lethal concentration: 320 mg/m³/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVN5* -,342,1993
inhalation
guinea pig lethal concentration : 160 mg/m³/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVN5* -,342,1993
inhalation
human lowest published toxic concentration: 77 mg/m³ Lung, Thorax, or Respiration: Cough VCVN5* -,342,1993
inhalation
mouse lethal concentration (50 percent kill): 150 ppm/1 hour Eye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 29,10,1968
inhalation
mouse lethal concentration (50 percent kill): 1,250 mg/m³/5 minute N/R VCVN5* -,342,1993
inhalation
mouse lethal concentration (50 percent kill): 250 mg/m³/60 minute N/R VCVN5* -,342,1993
inhalation
mouse lowest published lethal concentration: 320 mg/m³/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVN5* -,342,1993
inhalation
mouse lethal concentration : 160 mg/m³/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVN5* -,342,1993
inhalation
rat lethal concentration (50 percent kill): 185 ppm/1 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 29,10,1968
inhalation
rat lethal concentration (50 percent kill): 1,250 mg/m³/5 minute N/R VCVN5* -,342,1993
inhalation
rat lethal concentration (50 percent kill): 250 mg/m³/60 minute N/R VCVN5* -,342,1993
inhalation
rat lowest published lethal concentration: 320 mg/m³/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVN5* -,342,1993
inhalation
rat lethal concentration : 160 mg/m³/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVN5* -,342,1993
inhalation
rabbit lethal concentration (50 percent kill): 270 ppm/30 minute Eye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 29,10,1968
inhalation
rabbit lethal concentration (50 percent kill): 1,250 mg/m³/5 minute N/R VCVN5* -,342,1993
inhalation
rabbit lethal concentration (50 percent kill): 250 mg/m³/60 minute N/R VCVN5* -,342,1993
inhalation
rabbit lowest published lethal concentration: 320 mg/m³/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVN5* -,342,1993
inhalation
rabbit lethal concentration : 160 mg/m³/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVN5* -,342,1993
oral
rat lethal dose (75 percent kill): 50 mg/kg N/R VCVN5* -,342,1993

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
dog lowest published toxic concentration: 3 mg/m³/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough VCVN5* -,342,1989
inhalation
guinea pig lowest published toxic concentration: 3 mg/m³/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough VCVN5* -,342,1989
inhalation
mouse lowest published toxic concentration: 3 mg/m³/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough VCVN5* -,342,1989
inhalation
rat lowest published toxic concentration: 10 mg/m³/2 hour/10 day- intermittent Liver: Liver function tests impaired

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain STGNBT -,234,1999
inhalation
rat lowest published toxic concentration: 3 mg/m³/24 hour/35 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cough VCVN5* -,342,1989
inhalation
rat lowest published toxic concentration: 25 mg/m³/24 hour/35 day- continuous Musculoskeletal: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVN5* -,342,1989
inhalation
rat lowest published toxic concentration: 3 mg/m³/24 hour/35 day- continuous Musculoskeletal: Changes in teeth and supporting structures VCVN5* -,342,1989
inhalation
rat lowest published toxic concentration: 1 mg/m³/24 hour/30 day- continuous Musculoskeletal: Changes in teeth and supporting structures

Lung, Thorax, or Respiration: Other changes

Liver: Other changes VCVN5* -,343,1989
inhalation
rat lowest published toxic concentration: 3 mg/m³/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough VCVN5* -,342,1989
inhalation
rabbit lowest published toxic concentration: 3 mg/m³/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough VCVN5* -,342,1989
oral
rat lowest published toxic dose: 75 mg/kg/30 day- continuous Musculoskeletal: Changes in teeth and supporting structures

Lung, Thorax, or Respiration: Other changes

Liver: Other changes VCVN5* -,343,1989
oral
rat lowest published toxic dose: 630 mg/kg/6 week- continuous Musculoskeletal: Changes in teeth and supporting structures VCVN5* -,343,1989
oral
rat lowest published toxic dose: 1,368.7 mg/kg/2 year- continuous Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Musculoskeletal: Other changes VCVN5* -,343,1989

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 2 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
JAVMA4 164,277,1974
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
IECHAD 26,791,1934
TOXICOLOGY REVIEW
TOLED5 134,3,2002

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (2 mg/m³) DTLVS* 3,117,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.2 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.2 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.2 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.2 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (2 mg/m³), short term exposure limit 2 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.2 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (1.6 mg/m³), short term exposure limit 2 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.2 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.26 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VLE 1 ppm (2 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.2 mg/m³), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.2 mg/m³, short term exposure limit 0.4 mg/m³, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.2 mg/m³), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m³, MAC(short term exposure limit) 0.4 mg/m³, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.1 ppm (0.2 mg/m³), KTV 0.3 ppm (0.5 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.15 mg/m³), KZG- week 0.2 ppm (0.3 mg/m³), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 1 ppm (1.6 mg/m³), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 2 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORINE-air 10 hour time-weighted average 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 33370;
Number of Industries 10;
Total Number of Facilities 396;
Number of Occupations 13;
Total Number of Employees Exposed 2,580
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 33370;
Number of Industries 19;
Total Number of Facilities 490;
Number of Occupations 25;
Total Number of Employees Exposed 12,854;
Total Number of Female Employees Exposed 2,059

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS PB/93/182566/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE**

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL.
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

RTECS Compound Description:
Human Data
Primary Irritant

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