The Registry of Toxic Effects of Chemical Substances

Fibrous glass

RTECS #: LK3651000

CAS #: 65997-17-3

UPDATE: May 2004 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 475' glass fibres
  2. E - glass fibres
  3. Fiberglass
  4. Fibrous glass (OSHA)
  1. Fibrous glass dust (ACGIH)
  2. Glass
  3. Glass fibers


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test hamster lung 2 痢/cm2 MUREAV 391,111,1997
other mutation test systems hamster ovary 10 mg/L MUREAV 116,369,1983
other mutation test systems human fibroblast 10 mg/L MUREAV 116,369,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/7 hour/90 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NTIS** PB83-258111
implant
mouse 		toxic dose : 1,600 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		BJURAN 36,225,1964
implant
rat 		lowest published toxic dose: 200 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		JJIND8 67,965,1981
implant
rat 		toxic dose : 200 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		IARCCD 8,289,1973
intrapleural
rat 		toxic dose : 100 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		IAPUDO 30,311,1980
intraperitoneal
hamster 		lowest published toxic dose: 400 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		IAPUDO 30,337,1980
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		IAPUDO 30,337,1980
intraperitoneal
rabbit 		lowest published toxic dose: 25 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		IAPUDO 30,337,1980
intratracheal
hamster 		lowest published toxic dose: 125 mg/kg/5 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		ENVRAL 54,52,1991


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
mouse 		lethal dose : >20 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		ARDSBL 141(Suppl),A3-A937,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 30 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		TOXID9 36(1,pt2),7,1997
inhalation
hamster 		lowest published toxic concentration: 30 mg/m3/6 hour/78 week- intermittent Lung, Thorax, or Respiration: Other changes TOXID9 42,178,1998
inhalation
rat 		lowest published toxic concentration: 16 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes FAATDF 32,31,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 81,-,2002
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 81,-,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD NUISANCE PARTICULATES (fibrous or dust) DTLVS* 3,114,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FIBROUS GLASS-air 10 hour time-weighted average 3 million fiber/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
BJURAN British Journal of Urology. (Longman Group Ltd., POB 11318, Birmingham, AL 35202) V.1- 1929-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979-
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 94551-77-6
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