The Registry of Toxic Effects of Chemical Substances
Fibrous glass |
UPDATE: May 2004 | MW: N/R | MF: N/R |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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micronucleus test
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hamster
lung
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2 µg/cm2
|
MUREAV 391,111,1997
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other mutation test systems
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hamster
ovary
|
10 mg/L
|
MUREAV 116,369,1983
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other mutation test systems
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human
fibroblast
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10 mg/L
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MUREAV 116,369,1983
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lowest published toxic concentration: 5 mg/m3/7 hour/90 week- intermittent
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Tumorigenic: Carcinogenic by RTECS criteria | Blood: Leukemia
NTIS** PB83-258111
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implant | mouse
toxic dose : 1,600 mg/kg
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors Kidney, Ureter, and Bladder: Bladder tumors
BJURAN 36,225,1964
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implant | rat
lowest published toxic dose: 200 mg/kg
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Tumorigenic: Neoplastic by RTECS criteria | Tumorigenic: Tumors at site of application
JJIND8 67,965,1981
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implant | rat
toxic dose : 200 mg/kg
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Tumorigenic: Tumors at site of application
IARCCD 8,289,1973
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intrapleural | rat
toxic dose : 100 mg/kg
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors
IAPUDO 30,311,1980
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intraperitoneal | hamster
lowest published toxic dose: 400 mg/kg
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Gastrointestinal: Tumors
IAPUDO 30,337,1980
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intraperitoneal | rat
lowest published toxic dose: 50 mg/kg
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Gastrointestinal: Tumors
IAPUDO 30,337,1980
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intraperitoneal | rabbit
lowest published toxic dose: 25 mg/kg
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Gastrointestinal: Tumors
IAPUDO 30,337,1980
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intratracheal | hamster
lowest published toxic dose: 125 mg/kg/5 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors
ENVRAL 54,52,1991
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intratracheal | mouse
lethal dose : >20 mg/kg
|
Lung, Thorax, or Respiration: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARDSBL 141(Suppl),A3-A937,1990
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
inhalation | hamster
lowest published toxic concentration: 30 mg/m3/6 hour/13 week- intermittent
|
Lung, Thorax, or Respiration: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOXID9 36(1,pt2),7,1997
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inhalation | hamster
lowest published toxic concentration: 30 mg/m3/6 hour/78 week- intermittent
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Lung, Thorax, or Respiration: Other changes
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TOXID9 42,178,1998
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inhalation | rat
lowest published toxic concentration: 16 mg/m3/6 hour/13 week- intermittent
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Lung, Thorax, or Respiration: Other changes
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FAATDF 32,31,1996
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REVIEWS:
ORGANIZATION
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STANDARD
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|
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
Not classifiable as a human carcinogen
|
DTLVS* TLV/BEI,1999
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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Confirmed animal carcinogen
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DTLVS* TLV/BEI,1999
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal Sufficient Evidence
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IMEMDT 81,-,2002
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 2B
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IMEMDT 81,-,2002
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
|
|
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD
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NUISANCE PARTICULATES (fibrous or dust)
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DTLVS* 3,114,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
|
8 hour time-weighted average 15 mg/m3, total dust
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 5 mg/m3, respirable fraction
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
|
8 hour time-weighted average 15 mg/m3, total dust
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 5 mg/m3, respirable fraction
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CFRGBR 29,1915.1000,1993
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
|
|
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FIBROUS GLASS-air
|
10 hour time-weighted average 3 million fiber/m3
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NIOSH* DHHS #92-100,1992
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
ARDSBL
|
American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY
10019) V.80- 1959-
|
BJURAN
|
British Journal of Urology. (Longman Group Ltd., POB 11318, Birmingham, AL 35202) V.1-
1929-
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CFRGBR
|
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
|
The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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ENVRAL
|
Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-
1967-
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FAATDF
|
Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
|
IAPUDO
|
IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27-
1979-
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IARCCD
|
IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher
information, see IAPUDO.
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IMEMDT
|
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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JJIND8
|
JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For
publisher information, see JNCIEQ.
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MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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