The Registry of Toxic Effects of Chemical Substances
Ferric chloride |
UPDATE: May 2004 | MW: 162.20 | MF: Cl3Fe |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
DNA damage | human other cell types | 1 痠ol/L/1 hour | EMMUEG 38,1,2001 |
DNA damage | human other cell types | 0.4 mmol/L/30 minute | TCMUD8 20,11,2000 |
other mutation test systems | Escherichia coli | 500 nmol/tube | LAMEDS 6,252,1986 |
phage inhibition capacity | Escherichia coli | 41 ng/well | MUREAV 260,349,1991 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intratesticular rat | lowest published toxic dose: 12,976 痢/kg (1 day male) |
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | JRPFA4 7,21,1964 |
intravaginal rat | lowest published toxic dose: 29 mg/kg (1 day prior to copulation) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | CCPTAY 4,91,1971 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal mouse | lethal dose (50 percent kill): 375 mg/kg | N/R | VCVN5* -,431,1989 |
intraperitoneal rat | lethal dose (50 percent kill): 440 mg/kg | N/R | VCVN5* -,431,1989 |
intravenous mouse | lethal dose (50 percent kill): 58 mg/kg | N/R | YKKZAJ 87,677,1967 |
oral mouse | lethal dose (50 percent kill): 200 mg/kg | N/R | NAYXEW 11,1,1991 |
oral rat | lethal dose (50 percent kill): 316 mg/kg | N/R | NAYXEW 11,1,1991 |
oral woman | lowest published lethal dose: 4 mL/kg |
Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | VHTODE 40,31,1998 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral rat | lowest published toxic dose: 7,728 mg/kg/30 week- continuous |
Behavioral: Fluid intake Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 39(5),16,1974 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 1 mg(Fe)/m3 | DTLVS* TLV/BEI,1999 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 1 mg(Fe)/m3 | DTLVS* 3,138,1971 |
Occupational Exposure Limit - FINLAND | time-weighted average 1 mg(Fe)/m3, JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 1 mg(Fe)/m3, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 1 mg(Fe)/m3, JAN1993 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 1 mg(Fe)/m3 | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg(Fe)/m3 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 33160; Number of Industries 51; Total Number of Facilities 3,137; Number of Occupations 37; Total Number of Employees Exposed 27,934 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X6846![]() Number of Industries 1; Total Number of Facilities 39; Number of Occupations 1; Total Number of Employees Exposed 39 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 33160![]() Number of Industries 70; Total Number of Facilities 5,021; Number of Occupations 79; Total Number of Employees Exposed 108,492; Total Number of Female Employees Exposed 52,117 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used in sewage and drinking water treatments, etchant for photoengraving and rotogravure | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
CCPTAY | Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
JRPFA4 | Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- |
LAMEDS | LARC Medical. (19 bis, rue d'Inkermann, 59000 Lille, France) V.1- 1981- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NAYXEW | Nanjing Yixueyuan Xuebao. Journal of Nanjing Medical College. (Nanjing Yixueyuan, 140 Hanzhonglu, Nanjing, Peop. Rep. China) V.1- 1981(?)- |
TCMUD8 | Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- |
VCVN5* | "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989. |
VHTODE | Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- |
YKKZAJ | Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- |