The Registry of Toxic Effects of Chemical Substances

Ferric chloride

RTECS #: LJ9100000

CAS #: 7705-08-0

UPDATE: May 2004 MW: 162.20 MF: Cl3Fe


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Chlorure perrique (French)
  2. Flores martis
  3. Iron chloride
  1. Iron (III) chloride
  2. Iron trichloride
  3. Perchlorure de fer (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human other cell types 1 µmol/L/1 hour EMMUEG 38,1,2001
DNA damage human other cell types 0.4 mmol/L/30 minute TCMUD8 20,11,2000
other mutation test systems Escherichia coli 500 nmol/tube LAMEDS 6,252,1986
phage inhibition capacity Escherichia coli 41 ng/well MUREAV 260,349,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
rat 		lowest published toxic dose: 12,976 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964
intravaginal
rat 		lowest published toxic dose: 29 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) CCPTAY 4,91,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 375 mg/kg N/R VCVN5* -,431,1989
intraperitoneal
rat 		lethal dose (50 percent kill): 440 mg/kg N/R VCVN5* -,431,1989
intravenous
mouse 		lethal dose (50 percent kill): 58 mg/kg N/R YKKZAJ 87,677,1967
oral
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R NAYXEW 11,1,1991
oral
rat 		lethal dose (50 percent kill): 316 mg/kg N/R NAYXEW 11,1,1991
oral
woman 		lowest published lethal dose: 4 mL/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		VHTODE 40,31,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 7,728 mg/kg/30 week- continuous Behavioral: Fluid intake

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 39(5),16,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg(Fe)/m3 DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Fe)/m3 DTLVS* 3,138,1971
Occupational Exposure Limit - FINLAND time-weighted average 1 mg(Fe)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 mg(Fe)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg(Fe)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 mg(Fe)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 mg(Fe)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 33160;
Number of Industries 51;
Total Number of Facilities 3,137;
Number of Occupations 37;
Total Number of Employees Exposed 27,934
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6846;
Number of Industries 1;
Total Number of Facilities 39;
Number of Occupations 1;
Total Number of Employees Exposed 39
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 33160;
Number of Industries 70;
Total Number of Facilities 5,021;
Number of Occupations 79;
Total Number of Employees Exposed 108,492;
Total Number of Female Employees Exposed 52,117


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in sewage and drinking water treatments, etchant for photoengraving and rotogravure
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
LAMEDS LARC Medical. (19 bis, rue d'Inkermann, 59000 Lille, France) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAYXEW Nanjing Yixueyuan Xuebao. Journal of Nanjing Medical College. (Nanjing Yixueyuan, 140 Hanzhonglu, Nanjing, Peop. Rep. China) V.1- 1981(?)-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used in sewage and drinking water treatments, etchant for photoengraving and rotogravure

NIOSH PROFILE (IRON AND ITS COMPOUNDS), SRC, 3/82

NIOSH PROFILE (PRINTING INDUSTRY), SRC, 10/77

NIOSH PROFILE (SEWAGE TREATMENT), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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