The Registry of Toxic Effects of Chemical Substances

Ethylene oxide

RTECS #: KX2450000

CAS #: 75-21-8

UPDATE: May 2005 MW: 44.06 MF: C2H4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Epoxyaethan (German)
  2. 1,2 - Epoxyethane
  3. Aethylenoxid (German)
  4. Amprolene
  5. Anprolene
  6. Anproline
  7. Dihydrooxirene
  8. Dimethylene oxide
  9. E.O.
  10. ENT - 26263
  11. EO
  12. ETO
  13. Epoxyethane
  14. Ethene oxide
  15. Ethox
  16. Ethyleenoxide (Dutch)
  17. Ethylene (oxyde d') (French)
  18. Ethylene oxide (ACGIH:OSHA)
  1. Etilene (ossido di) (Italian)
  2. Etylenu tlenek (Polish)
  3. FEMA No. 2433
  4. Merpol
  5. NCI - C50088
  6. Oxacyclopropane
  7. Oxane
  8. Oxidoethane
  9. Oxiraan (Dutch)
  10. Oxiran
  11. Oxirane
  12. Oxirene, dihydro -
  13. Oxyfume
  14. Oxyfume 12
  15. RCRA waste number U115
  16. Sterilizing gas ethylene oxide 100%
  17. T - Gas
  18. alpha,beta - Oxidoethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		18 mg/6 hour moderate BUYRAI 31,25,1977
skin
human 		1%/7S AMIHBC 2,549,1950


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
Drosophila melanogaster 		55 mmol/L ZEVBA5 92,457,1961
cytogenetic analysis hamster fibroblast 250 ppm ESKHA5 (102),77,1984
cytogenetic analysis inhalation
human 		5 ppm/1 year MUREAV 170,55,1986
cytogenetic analysis inhalation
monkey 		100 ppm/7 hour/2 year- intermittent TXAPA9 76,85,1984
cytogenetic analysis inhalation
monkey 		100 ppm/104 week MUREAV 492,59,2001
cytogenetic analysis inhalation
mouse 		400 ppm/6 hour- continuous ARTODN 59,332,1987
cytogenetic analysis intraperitoneal
mouse 		88,120 µg/kg MUREAV 288,223,1993
cytogenetic analysis inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis rat bone marrow 30 µg/L/2 day TNICS* 13,47,1973
cytogenetic analysis inhalation
rat 		1 µg/L/17 week TPKVAL 13,51,1973
cytogenetic analysis oral
rat 		9 mg/kg TPKVAL 12,72,1971
dominant lethal test inhalation
mouse 		204 ppm/6 hour/48 day- intermittent EMMUEG 16,126,1990
dominant lethal test intraperitoneal
mouse 		150 mg/kg ENMUDM 2,252,1980
dominant lethal test inhalation
rat 		1,000 ppm/4 hour TXAPA9 40,261,1977
dominant lethal test subcutaneous
rat 		40 mg/kg GISAAA 48(1),23,1983
DNA adduct inhalation
Drosophila melanogaster 		2 ppm/24 hour MUREAV 529,95,2003
DNA adduct inhalation
mouse 		100 ppm/6 hour/6 week- intermittent TOXID9 72(Supp 1),249,2003
DNA damage human fibroblast 5 mmol/L EMMUEG 24,161,1994
DNA damage intraperitoneal
mouse 		100 mg/kg MUREAV 197,93,1988
DNA damage inhalation
mouse 		1,800 ppm/1 hour- continuous MUREAV 209,177,1988
unscheduled DNA synthesis human leukocyte 4 mmol/L CBINA8 47,265,1983
unscheduled DNA synthesis inhalation
mouse 		300 ppm ENMUDM 1,166,1979
mutation in microorganisms Escherichia coli 3,500 µmol/10 hour (-enzymatic activation step) MUREAV 24,83,1974
mutation in microorganisms Neurospora crassa 140 mmol/L/10 minute (-enzymatic activation step) MGGEAE 101,185,1968
mutation in microorganisms other microorganisms 540 mg/L (-enzymatic activation step) 47YKAF 8,273,1981
mutation in microorganisms Salmonella typhimurium 40 µmol/plate (+enzymatic activation step) FCTXAV 18,115,1980
mutation in microorganisms Salmonella typhimurium 20 ppm (-enzymatic activation step) EMMUEG 11,65,1988
mutation in microorganisms Saccharomyes cerevisiae 25 mmol/L (-enzymatic activation step) MUREAV 250,229,1991
micronucleus test intraperitoneal
mouse 		150 mg/kg MUREAV 75,191,1980
micronucleus test intravenous
mouse 		200 mg/kg APTOA6 43,69,1978
micronucleus test inhalation
mouse 		380 ppm/3 hour- continuous ESKHA5 (102),84,1984
micronucleus test intravenous
rat 		200 mg/kg APTOA6 43,69,1978
micronucleus test inhalation
rat 		200 ppm/6 hour/4 week- intermittent MUREAV 324,87,1994
micronucleus test intraperitoneal
rat 		50 ppm MUREAV 492,59,2001
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mmol/L MUREAV 250,229,1991
mutation in mammalian somatic cells hamster ovary 5 mg/L/1 hour JTEHD6 12,27,1983
mutation in mammalian somatic cells hamster lung 7,500 ppm/2 hour- continuous ENMUDM 8,67,1986
mutation in mammalian somatic cells human fibroblast 5 mmol/L MUREAV 287,283,1993
mutation in mammalian somatic cells intraperitoneal
mouse 		200 mg/kg/3 day- intermittent MUREAV 288,151,1993
mutation in mammalian somatic cells mouse lymphocyte 5 µmol/L PAACA3 21,74,1980
mutation in mammalian somatic cells inhalation
mouse 		200 ppm/6 hour/4 week- intermittent MUREAV 392,211,1997
morphological transform hamster embryo 625 ppm/2 hour- continuous ENMUDM 8,67,1986
morphological transform mouse embryo 2,500 µmol/L MUTAEX 4,58,1989
sister chromatid exchange human lymphocyte 4 pph TCMUD8 6,15,1986
sister chromatid exchange human fibroblast 36 ppm/24 hour ZHPMAT 170,548,1980
sister chromatid exchange human lymphocyte 10 mg/L PHMGBN 25,214,1982
sister chromatid exchange inhalation
human 		380 ppb/6 hour/4 year- intermittent SWEHDO 17,60,1991
sister chromatid exchange inhalation
human 		60 ppm/12 week- intermittent MUREAV 281,31,1992
sister chromatid exchange inhalation
monkey 		50 ppm/7 hour/2 year- intermittent TXAPA9 76,85,1984
sister chromatid exchange intraperitoneal
mouse 		88,120 µg/kg MUREAV 288,223,1993
sister chromatid exchange inhalation
rat 		50 ppm/6 hour/3 day- continuous MUREAV 120,37,1983
sister chromatid exchange inhalation
rat 		50 ppm/4 week MUREAV 492,59,2001
sister chromatid exchange intraperitoneal
rat 		50 ppm MUREAV 492,59,2001
sister chromatid exchange inhalation
rabbit 		50 ppm/12 week- intermittent ENMUDM 4,121,1982
sister chromatid exchange inhalation
rabbit 		250 ppm/12 week MUREAV 492,59,2001
sister chromatid exchange Saccharomyes cerevisiae 25 mmol/L MUREAV 250,229,1991
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		55 mmol/L ZEVBA5 92,457,1961
specific locus test parenteral
Drosophila melanogaster 		114 mmol/L CNREA8 30,195,1970
specific locus test inhalation
Drosophila melanogaster 		750 ppm MUREAV 405,259,1998
specific locus test inhalation
Drosophila melanogaster 		3.9 ppm/24 hour MUREAV 529,95,2003
specific locus test inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
heritable translocation test intraperitoneal
mouse 		30 mg/kg/25 day- intermittent ENMUDM 2,252,1980
heritable translocation test inhalation
mouse 		165 ppm/6 hour/48 day- intermittent EMMUEG 16,126,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
monkey 		lowest published toxic concentration: 50 ppm/7 hour (96 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ATAREK 8-84,7,1984
inhalation
monkey 		lowest published toxic concentration: 50 ppm/7 hour (2 year male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 3,60,1983
inhalation
mouse 		lowest published toxic concentration: 255 ppm/6 hour (10 day male) Reproductive: Effects on embryo or fetus: Fetal death MUREAV 119,377,1983
inhalation
mouse 		lowest published toxic concentration: 1,200 ppm/90 minute (1 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Homeostasis 		MUREAV 176,269,1987
inhalation
mouse 		lowest published toxic concentration: 1,200 ppm/90 minute (1 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus 		TJADAB 39,563,1989
inhalation
mouse 		lowest published toxic concentration: 2,700 ppm/6 hour (7 day pregnant) Reproductive: Other effects to embryo or fetus TJADAB 57,231,1998
inhalation
mouse 		lowest published toxic concentration: 1,800 ppm/1.5 hour (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOSCF2 50,259,1999
inhalation
rat 		lowest published toxic concentration: 50 ppm/6 hour (91 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NEZAAQ 45,592,1990
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 48,A84,1979
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour (12 week male/9 week prior to copulation-3 week pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TXAPA9 48,A84,1979
inhalation
rat 		lowest published toxic concentration: 3,600 µg/m3/24 hour (60 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 		TPKVAL 14,11,1975
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour (12 week prior to copulation-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		TXAPA9 63,382,1982
inhalation
rat 		lowest published toxic concentration: 150 ppm/7 hour (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** PB83-258038
intraperitoneal
mouse 		lowest published toxic dose: 750 mg/kg (25 day male) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Delayed effects 		MUREAV 73,133,1980
intraperitoneal
mouse 		lowest published toxic dose: 150 mg/kg (1 day male) Reproductive: Effects on embryo or fetus: Fetal death MUREAV 73,133,1980
intraperitoneal
mouse 		lowest published toxic dose: 125 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Eye, ear 		TJADAB 53,1,1996
intraperitoneal
mouse 		lowest published toxic dose: 125 mg/kg (1 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		TJADAB 53,1,1996
intravenous
mouse 		lowest published toxic dose: 225 mg/kg (10-12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 19,34A,1979
intravenous
mouse 		lowest published toxic dose: 450 mg/kg (8-10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 19,34A,1979
intravenous
mouse 		lowest published toxic dose: 450 mg/kg (10-12 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 56,16,1980
intravenous
rabbit 		lowest published toxic dose: 324 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** PB83-242016
intravenous
rabbit 		lowest published toxic dose: 81 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** #PB83-242016
intravenous
rabbit 		lowest published toxic dose: 81 mg/kg (6-14 day pregnant) Reproductive: Effects on newborn: Sex ratio NTIS** #PB83-242016


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic dose: 50 ppm/6 hour/2 year Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTPTR* NTP-TR-326,1987
inhalation
mouse 		lowest published toxic concentration: 3,060 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB88-169859
inhalation
mouse 		lowest published toxic concentration: 3,060 mg/kg/102 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		NTIS** PB88-169859
inhalation
rat 		lowest published toxic concentration: 33 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Blood: Leukemia 		TXAPA9 75,105,1984
inhalation
rat 		toxic concentration (other than lowest) : 50 ppm/7 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors 		TXAPA9 76,69,1984
inhalation
rat 		toxic concentration (other than lowest) : 33 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors 		NRTXDN 6,117,1985
inhalation
rat 		toxic concentration (other than lowest) : 33 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors 		FCTOD7 24,145,1986
oral
rat 		lowest published toxic dose: 1,186 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		BJCAAI 46,924,1982
oral
rat 		toxic dose : 5,112 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		BJCAAI 46,924,1982
subcutaneous
mouse 		lowest published toxic dose: 292 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		ZHPMAT 174,383,1981
subcutaneous
mouse 		toxic dose : 1,090 mg/kg/91 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		BJCAAI 39,588,1979
subcutaneous
mouse 		toxic dose : 908 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		ZHPMAT 174,383,1981
subcutaneous
mouse 		toxic dose : 2,576 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		ZHPMAT 174,383,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration (50 percent kill): 960 ppm/4 hour Eye: Lacrimation

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Hypermotility, diarrhea 		AMIHAB 13,237,1956
inhalation
guinea pig 		lethal concentration (50 percent kill): 1,500 mg/m3/4 hour N/R 85GMAT -,67,1982
inhalation
human 		lowest published toxic concentration: 12,500 ppm/10S Olfaction: Other olfaction effects JOHYAY 32,409,1932
inhalation
mouse 		lethal concentration (50 percent kill): 836 ppm/4 hour N/R NTIS** PB214-270
inhalation
rat 		lethal concentration (50 percent kill): 800 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		34ZIAG -,258,1969
inhalation
woman 		lowest published toxic concentration: 500 ppm/2 minute Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting

Lung, Thorax, or Respiration: Other changes 		DICPBB 15,384,1981
intraperitoneal
mouse 		lethal dose (50 percent kill): 175 mg/kg N/R GISAAA 48(1),23,1983
intravenous
dog 		lethal dose (50 percent kill): 330 mg/kg Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		JTCSAQ 61,309,1971
intravenous
mouse 		lethal dose (50 percent kill): 290 mg/kg N/R APTOA6 43,69,1978
intravenous
rabbit 		lowest published lethal dose: 175 mg/kg Eye: Other eye effects

Behavioral: Muscle weakness

Behavioral: Rigidity (includes catalepsy) 		JOHYAY 32,409,1932
oral
guinea pig 		lethal dose (50 percent kill): 270 mg/kg N/R JIHTAB 23,259,1941
oral
rat 		lethal dose (50 percent kill): 72 mg/kg N/R SPEADM 78-1,17,1978
subcutaneous
cat 		lowest published lethal dose: 100 mg/kg N/R HDWU** -,-,1933
subcutaneous
rat 		lethal dose (50 percent kill): 187 mg/kg N/R GISAAA 48(1),23,1983
unreported route
rat 		lowest published lethal dose: 200 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		34ZIAG -,258,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 290 ppm/6 hour/6 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		AMIHAB 13,237,1956
inhalation
dog 		lowest published toxic concentration: 102 ppm/26 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		AMIHAB 13,237,1956
inhalation
monkey 		lowest published toxic concentration: 100 ppm/7 hour/2 year- intermittent Eye: Other eye effects TOXID9 12,354,1992
inhalation
mouse 		lowest published toxic concentration: 800 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-326,1987
inhalation
mouse 		lowest published toxic concentration: 400 ppm/6 hour/13 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		JOUOD4 14,33,1992
inhalation
mouse 		lowest published toxic concentration: 600 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects

Endocrine: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-326,1987
inhalation
mouse 		lowest published toxic concentration: 450 mg/m3/6 hour/10 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Related to Chronic Data: Changes in testicular weight 		NTIS** OTS0534608
inhalation
rat 		lowest published toxic concentration: 406 ppm/6 hour/6 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 13,237,1956
inhalation
rat 		lowest published toxic concentration: 300 µg/m3/24 hour/83 day- continuous Behavioral: Muscle contraction or spasticity

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Cl 		GISAAA 31(10),3,1966
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/13 week- intermittent Behavioral: Food intake (animal)

Liver: Other changes 		NEZAAQ 43,1053,1988
intravenous
rabbit 		lowest published toxic dose: 81 mg/kg/9 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB83-242016
intravenous
rabbit 		lowest published toxic dose: 72 mg/kg/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB83-242016
intravenous
rabbit 		lowest published toxic dose: 144 mg/kg/4 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation NTIS** #PB83-242016


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 36,189,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMSUDL 7,205,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 60,73,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,73,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 60,73,1994
TOXICOLOGY REVIEW
JJOMDZ 15,808,1973
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
AEHLAU 8,700,1964
TOXICOLOGY REVIEW
CRTXB2 30,595,2000
TOXICOLOGY REVIEW
TOLED5 138,1,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 5432012003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004
TOXICOLOGY REVIEW
MUREAV 580,91,2005
TOXICOLOGY REVIEW
MUREAV 567,347,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,182,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (90 mg/m3) DTLVS* 3,112,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1147 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (90 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1047,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 10 ppm (20 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (2 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Skin, Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (1.8 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (1.8 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (2.8 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 1 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.84 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 ppm, short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 1 ppm (2 mg/m3), KTV 5 ppm (9 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (2 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (90 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (9.2 mg/m3), Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE OXIDE-air Carcinogen;
8 hour time-weighted average 0.1 ppm;
ceiling concentration 5 ppm/10 minute 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 32550;
Number of Industries 67;
Total Number of Facilities 7,411;
Number of Occupations 74;
Total Number of Employees Exposed 107,450
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 32550;
Number of Industries 89;
Total Number of Facilities 10,657;
Number of Occupations 104;
Total Number of Employees Exposed 270,683;
Total Number of Female Employees Exposed 120,086


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180554/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal; Rodent heritable translocation
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; N crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; UDS in mouse germ cells
EPA GENETOX PROGRAM 1988, Negative: Mouse specific locus
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in the production of glycols, nontonic surface-active agents and ethanolamines
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9104
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 35, MAY 1981
NIOSH CURRENT INTELLIGENCE BULLETIN 52, JULY 1989
NIOSH Analytical Method, 1994: Ethylene oxide, 1614 or by portable GC, 3702
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #30, SUPERSEDED BY #50
PASSIVE MONITOR, OSHA ANALYTICAL METHOD #49


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Used in the production of glycols, nontonic surface-active agents and ethanolamines

Top 50 chemical production: 5.56 billions lbs in 1992, 5.25 billions in 1991

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 19034-08-3
ALT CAS #: 99932-75-9
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