The Registry of Toxic Effects of Chemical Substances

Ethylene, 1,1 - difluoro -

RTECS #: KW0560000

CAS #: 75-38-7

UPDATE: May 2004 MW: 64.04 MF: C2H2F2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1 - Difluoroethene
  2. Ethene, 1,1 - difluoro -
  3. Halocarbon 1132A
  4. NCI - C60208
  1. VDF
  2. Vinylidene difluoride
  3. Vinylidene fluoride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 50 pph/24 hour (-enzymatic activation step) ARTODN 41,249,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,930 mg/kg/52 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Ear: Tumors

Skin and Appendages: Tumors 		MELAAD 70,363,1979
oral
rat 		lowest published toxic dose: 857 mg/kg/130 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		VCVGH* -,287,1990


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 800 ppb/4 hour N/R NTIS** OTS0523847
inhalation
rat 		lowest published lethal concentration: 128,000 ppm/4 hour Lung, Thorax, or Respiration: Other changes JOCMA7 4,262,1962
inhalation
rat 		lethal concentration (50 percent kill): 240,000 mg/m3/4 hour N/R VCVGH* -,287,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 40,000 ppm/6 hour/13 week- intermittent Behavioral: Excitement

Blood: Pigmented or nucleated red blood cells

Skin and Appendages: Other: Hair 		NTIS** OTS0522815
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in erythrocyte (RBC) count 		NTIS** OTS0523847


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 39,227,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Data IMEMDT 71,1551,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,227,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1551,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1551,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Suspected Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYLIDENE FLUORIDE-air use 29 Code of Federal Regulations (CFR) 1910.1017 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80234;
Number of Industries 2;
Total Number of Facilities 41;
Number of Occupations 4;
Total Number of Employees Exposed 1,467


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in manufacture of POLYVINYLIDENE FLUORIDE and elastomeric copolymers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67. For publisher information, see:JJOMDZ
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in manufacture of POLYVINYLIDENE FLUORIDE and elastomeric copolymers

RTECS Compound Description:
   Tumorigen
   Mutagen

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