The Registry of Toxic Effects of Chemical Substances
Ethylene glycol, dinitrate RTECS #: KW5600000
CAS #: 628-96-6
The Registry of Toxic Effects of Chemical Substances
Ethylene glycol, dinitrate |
| UPDATE: November 2004 | MW: 152.08 | MF: C2H4N2O6 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | mouse
lethal dose (50 percent kill): 540 mg/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Convulsions or effect on seizure threshold Cardiac: Other changes
STGNBT -,96,1999
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oral | rat
lethal dose (50 percent kill): 460 mg/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Convulsions or effect on seizure threshold Cardiac: Other changes
STGNBT -,96,1999
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subcutaneous | cat
lowest published lethal dose: 75 mg/kg
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Blood: Normocytic anemia
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AEPPAE 200,271,1942
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subcutaneous | rabbit
lowest published lethal dose: 300 mg/kg
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Vascular: Other changes | Blood: Normocytic anemia
AEPPAE 200,271,1942
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skin | rat
lethal dose (50 percent kill): 3,800 mg/kg
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N/R
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STGNBT -,96,1999
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 10 mg/m3/17 week- intermittent
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Cardiac: Other changes | Kidney, Ureter, and Bladder: Other changes Blood: Pigmented or nucleated red blood cells
STGNBT -,96,1999
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oral | rat
lowest published toxic dose: 3,067 mg/kg/20 day- intermittent
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Kidney, Ureter, and Bladder: Changes in kidney weight | Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain
STGNBT -,96,1999
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subcutaneous | rat
lowest published toxic dose: 1 gm/kg/10 day- intermittent
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Behavioral: Tolerance | Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
PHTOEH 61,172,1987
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 0.05 ppm (skin)
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DTLVS* TLV/BEI,2003
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TOXICOLOGY REVIEW
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NTIS** AD778-725
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TOXICOLOGY REVIEW
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AJMEAZ 38,409,1965
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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ceiling concentration 0.2 ppm (1 mg/m3) (skin)
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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ceiling concentration 0.2 ppm (1 mg/m3) (skin)
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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ceiling concentration 0.2 ppm (1 mg/m3) (skin)
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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ceiling concentration 0.2 ppm (1 mg/m3) (skin)
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 0.05 ppm (0.3 mg/m3), Skin, JAN1993
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Occupational Exposure Limit - AUSTRIA
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MAK 0.05 ppm (0.3 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - BELGIUM
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time-weighted average 0.05 ppm (0.31 mg/m3), Skin, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 0.02 ppm (0.12 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FINLAND
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time-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FRANCE
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VME 0.17 ppm (1 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - GERMANY
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MAK 0.05 ppm (0.3 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - JAPAN
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short term exposure limit 0.05 ppm (0.31 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 0.3 mg/m3, Skin, 2003
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Occupational Exposure Limit - NORWAY
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time-weighted average 0.03 ppm (0.18 mg/m3), JAN1999
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Occupational Exposure Limit - THE PHILIPPINES
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time-weighted average 0.2 ppm (1.2 mg/m3), Skin, JAN1993
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Occupational Exposure Limit - POLAND
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time-weighted average 0.3 mg/m3, short term exposure limit 0.4 mg/m3, JAN1999
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Occupational Exposure Limit - RUSSIA
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time-weighted average 0.05 mg/m3, JAN1993
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Occupational Exposure Limit - SWEDEN
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NGV 0.03 ppm (0.2 mg/m3), KTV 0.1 ppm (0.6 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.05 ppm (0.3 mg/m3), KZG- week 0.1 ppm, Skin, JAN1999
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Occupational Exposure Limit - THAILAND
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time-weighted average 0.2 ppm (1 mg/m3), JAN1993
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Occupational Exposure Limit - TURKEY
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time-weighted average 0.2 ppm (1 mg/m3), Skin, JAN1993
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 0.2 ppm (1.3 mg/m3), short term exposure limit 0.2 ppm, Skin, SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | time-weighted average 0.05 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
time-weighted average 0.05 ppm (skin) | ||||||||||||||||||||||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE GLYCOL DINITRATE-air
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short term exposure limit 0.1 mg/m3 (Sk)
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NIOSH* DHHS #92-100,1992
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Ethylene glycol dinitrate, 2507
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OSHA ANALYTICAL METHOD #43
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REFERENCES:
CODEN
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REFERENCE
AEPPAE
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Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.)
V.110-253, 1925-66. For publisher information, see NSAPCC.
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AJMEAZ
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American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1-
1946-
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CFRGBR
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Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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PHTOEH
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Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016
Copenhagen K, Denmark) V.60- 1987-
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STGNBT
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"Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh
Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St.,
123182, Moscow, Russia, IzdAT 1999
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