The Registry of Toxic Effects of Chemical Substances

Ethylene glycol

RTECS #: KW2975000

CAS #: 107-21-1

UPDATE: February 2005 MW: 62.08 MF: C2H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Dihydroxyethane
  2. 1,2 - Ethandiol
  3. 1,2 - Ethanediol
  4. Athylenglykol (German)
  5. Dowtherm SR 1
  6. Ethane - 1,2 - diol
  7. Ethylene alcohol
  8. Ethylene dihydrate
  9. Ethylene glycol (ACGIH)
  10. Ethylene glycol, aerosol
  1. Glycol alcohol
  2. Lutrol - 9
  3. M.E.G.
  4. Macrogol 400 BPC
  5. Monoethylene glycol
  6. NCI - C00920
  7. Norkool
  8. Tescol
  9. Ucar 17


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rat 		0.12%/3 day TXAPA9 16,646,1970
eye
rabbit 		500 mg/24 hour mild 85JCAE -,205,1986
eye
rabbit 		100 mg/1 hour mild NTIS** LMF-69
eye
rabbit 		0.12 ppm/3 day mild TXAPA9 16,646,1970
eye
rabbit 		1,440 mg/6 hour moderate BUYRAI 31,25,1977
skin
rabbit 		555 mg open irritation test mild UCDS** 7/21/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		1,200 mg/kg TGANAK 19,436,1985
DNA inhibition human lymphocyte 320 mmol/L PNASA6 79,1171,1982
mutation in mammalian somatic cells mouse lymphocyte 100 mmol/L PAACA3 21,74,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1,000 mg/m3/6 hour (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 		FAATDF 24,57,1995
inhalation
mouse 		lowest published toxic concentration: 1,000 mg/m3/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Sex ratio 		FAATDF 24,57,1995
inhalation
mouse 		lowest published toxic concentration: 2,100 mg/m3/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		FAATDF 27,49,1995
inhalation
mouse 		lowest published toxic concentration: 2,100 mg/m3/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FAATDF 27,49,1995
inhalation
rat 		lowest published toxic concentration: 2,500 mg/m3/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		FAATDF 24,57,1995
oral
mouse 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXAPA9 81,113,1985
oral
mouse 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 29(2),52A,1984
oral
mouse 		lowest published toxic dose: 84 gm/kg (1-21 day pregnant/21 day after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		TOXID9 4,136,1984
oral
mouse 		lowest published toxic dose: 88,720 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 15 gm/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Other measures of fertility 		NTIS** PB85-105385
oral
mouse 		lowest published toxic dose: 88,720 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 413 gm/kg (15 week male/15 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXAPA9 81,100,1985
oral
mouse 		lowest published toxic dose: 413 gm/kg (15 week male/15 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Delayed effects TXAPA9 81,100,1985
oral
mouse 		lowest published toxic dose: 1.7 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB84241108
oral
mouse 		lowest published toxic dose: 1.7 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Central nervous system NTIS** #PB84241108
oral
mouse 		lowest published toxic dose: 1.7 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS** #PB84241108
oral
mouse 		lowest published toxic dose: 7.5 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB85-105385
oral
mouse 		lowest published toxic dose: 7.5 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		NTIS** #PB85-105385
oral
mouse 		lowest published toxic dose: 29.75 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB84241108
oral
mouse 		lowest published toxic dose: 59.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility 		NTIS** #PB84241108
oral
mouse 		lowest published toxic dose: 98 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB86177383
oral
mouse 		lowest published toxic dose: 294 gm/kg (15 week prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB86177383
oral
mouse 		lowest published toxic dose: 15 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** #PB85-105385
oral
mouse 		lowest published toxic dose: 15 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** #PB85-105385
oral
mouse 		lowest published toxic dose: 850 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB86177383
oral
mouse 		lowest published toxic dose: 850 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB86177383
oral
rat 		lowest published toxic dose: 50 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) 		TXAPA9 81,113,1985
oral
rat 		lowest published toxic dose: 8,580 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		CHYCDW 20,289,1986
oral
rat 		lowest published toxic dose: 12,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 29(2),52A,1984
oral
rat 		lowest published toxic dose: 25 gm/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** PB85-104594
oral
rat 		lowest published toxic dose: 51,948 mg/kg (13 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct WDZAEK 8,12,1994
oral
rat 		lowest published toxic dose: 18.8 gm/kg (6-20 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** #PB88-204326/AS
oral
rat 		lowest published toxic dose: 25,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NTIS** #PB95-274528
oral
rat 		lowest published toxic dose: 33,750 mg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB88-204326/AS
oral
rat 		lowest published toxic dose: 33,750 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** #PB88-204326/AS
oral
rabbit 		lowest published toxic dose: 28 gm/kg (6-19 day pregnant) Reproductive: Other effects on female NTIS** PB91-211219
oral
rabbit 		lowest published toxic dose: 28,000 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Stillbirth 		NTIS** #PB91-211219
unreported route
mouse 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		VCVGK* -,140,1994
unreported route
mouse 		lowest published toxic dose: 750 mg/kg (multigenerations) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		VCVGK* -,140,1994
unreported route
rat 		lowest published toxic dose: 50,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		VCVGK* -,140,1994
unreported route
rat 		lowest published toxic dose: 5,000 mg/kg (multigenerations) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		VCVGK* -,140,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		lowest published toxic dose: 10 pph Eye: Conjunctiva irritation VCVGK* -,141,1984
inhalation
human 		lowest published toxic concentration: 10,000 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes 		AGGHAR 5,1,1933
inhalation
human 		lowest published toxic concentration: 22 mg/m3 Kidney, Ureter, and Bladder: Proteinuria IAEHDW 69,255,1997
inhalation
mouse 		lethal concentration : >200 mg/m3/2 hour N/R GTPZAB 25(11),57,1981
inhalation
rat 		lethal concentration : >200 mg/m3/4 hour N/R GTPZAB 25(11),57,1981
inhalation
rabbit 		lowest published toxic concentration: 4 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,139,1984
inhalation
rabbit 		lowest published toxic concentration: 12 mg/m3 Eye: Conjunctiva irritation VCVGK* -,141,1984
intramuscular
rat 		lowest published lethal dose: 3,300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation 		JPETAB 41,387,1931
intramuscular
rat 		lowest published lethal dose: 3,300 mg/kg N/R VCVGK* -,139,1984
intramuscular
rabbit 		lowest published lethal dose: 5,500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation 		JPETAB 41,387,1931
intramuscular
rabbit 		lowest published lethal dose: 5,500 mg/kg N/R VCVGK* -,139,1984
intraperitoneal
monkey 		lowest published lethal dose: 4,000 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVGK* -,140,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,614 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen 		FEPRA7 6,342,1947
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,700 mg/kg N/R VCVGK* -,139,1984
intraperitoneal
rat 		lethal dose (50 percent kill): 5,010 mg/kg N/R KRKRDT 9,36,1981
intraperitoneal
rabbit 		lowest published lethal dose: 1,000 mg/kg N/R VCVGK* -,139,1984
intravenous
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R VCVGK* -,139,1984
intravenous
rat 		lethal dose (50 percent kill): 3,260 mg/kg N/R KRKRDT 9,36,1981
intravenous
rat 		lowest published lethal dose: 2,800 mg/kg N/R VCVGK* -,139,1984
intravenous
rabbit 		lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JPETAB 41,387,1931
intravenous
rabbit 		lowest published lethal dose: 5,000 mg/kg N/R VCVGK* -,139,1984
oral
cat 		lethal dose (50 percent kill): 1,650 mg/kg Kidney, Ureter, and Bladder: Other changes RMVEAG 154,137,1978
oral
cat 		lethal dose (50 percent kill): 2,000 mg/kg N/R VCVGK* -,139,1984
oral
child 		lowest published toxic dose: 5,500 mg/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes 		PGMJAO 52,598,1976
oral
dog 		lethal dose (50 percent kill): 5,500 mg/kg Kidney, Ureter, and Bladder: Other changes RMVEAG 154,137,1978
oral
guinea pig 		lethal dose (50 percent kill): 6,610 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
oral
guinea pig 		lethal dose (50 percent kill): 6,600 mg/kg N/R VCVGK* -,139,1984
oral
human 		lowest published lethal dose: 786 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Gastrointestinal: Hypermotility, diarrhea 		EJTXAZ 9,373,1976
oral
human 		lowest published lethal dose: 398 mg/kg Behavioral: Headache

Gastrointestinal: Nausea or vomiting

Liver: Other changes 		SMEZA5 26(2),48,1983
oral
man 		lowest published toxic dose: 24 gm/kg Brain and Coverings: Recordings from specific areas of CNS

Eye: Mydriasis (pupilliary dilation)

Lung, Thorax, or Respiration: Other changes 		JTCTDW 38,445,2000
oral
man 		lowest published toxic dose: 15 gm/kg Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Gastrointestinal: Ulceration or bleeding from small intestine

Kidney, Ureter, and Bladder: Renal function tests depressed 		AEMED3 20,208,1991
oral
man 		lowest published toxic dose: 1,195 mg/kg Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Kidney, Ureter, and Bladder: Renal function tests depressed 		AEMED3 20,208,1991
oral
man 		lowest published toxic dose: 16 gm/kg Behavioral: Coma

Kidney, Ureter, and Bladder: Renal function tests depressed

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		HETOEA 9,317,1990
oral
man 		lowest published toxic dose: 24 gm/kg Brain and Coverings: Recordings from specific areas of CNS

Brain and Coverings: Other degenerative changes 		JTCTDW 38,445,2000
oral
man 		lowest published toxic dose: 24 gm/kg Brain and Coverings: Other degenerative changes

Behavioral: Ataxia

Behavioral: Coma 		JTCTDW 38,445,2000
oral
mouse 		lethal dose (50 percent kill): 5,500 mg/kg N/R GISAAA 32(3),31,1967
oral
rat 		lethal dose (50 percent kill): 4,700 mg/kg N/R VCVGK* -,139,1984
oral
rat 		lowest published toxic dose: 1,110 mg/kg Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVGK* -,139,1984
oral
rat 		lowest published toxic dose: 5,000 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Tetany

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		VCVGK* -,139,1984
oral
rat 		lowest published toxic dose: 1,000 mg/kg Brain and Coverings: Increased intracranial pressure

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,139,1984
oral
rat 		lowest published toxic dose: 120 mg/kg Blood: Changes in bone marrow not included in above VCVGK* -,140,1984
subcutaneous
cat 		lowest published lethal dose: 2 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Blood: Other changes 		AGGHAR 5,1,1933
subcutaneous
cat 		lowest published lethal dose: 2,000 mg/kg N/R VCVGK* -,139,1984
subcutaneous
guinea pig 		lowest published lethal dose: 5,000 mg/kg N/R VCVGK* -,139,1984
subcutaneous
mouse 		lowest published lethal dose: 2,700 mg/kg N/R BJIMAG 1,207,1944
subcutaneous
mouse 		lethal dose (50 percent kill): 2,700 mg/kg N/R VCVGK* -,139,1984
subcutaneous
mouse 		lowest published toxic dose: 5,000 mg/kg Kidney, Ureter, and Bladder: Renal function tests depressed EKFAE9 55,21,1992
subcutaneous
rat 		lethal dose (50 percent kill): 2,800 mg/kg N/R NPIRI* 1,49,1974
subcutaneous
rat 		lowest published toxic dose: 3,000 mg/kg Kidney, Ureter, and Bladder: Renal function tests depressed EKFAE9 55,21,1992
subcutaneous
rabbit 		lethal dose (50 percent kill): 19,500 mg/kg N/R VCVGK* -,139,1984
skin
rabbit 		lethal dose (50 percent kill): 9,530 µL/kg N/R 34ZIAG -,731,1969
unreported route
guinea pig 		lethal dose (50 percent kill): 11,150 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting 		GISAAA 33(3),16,1968
unreported route
human 		lowest published lethal dose: 70 mg/kg Cardiac: Change in rate

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes 		VCVGK* -,140,1984
unreported route
man 		lowest published lethal dose: 1,637 mg/kg N/R 85DCAI 2,73,1970
unreported route
mouse 		lethal dose (50 percent kill): 8,050 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting 		GISAAA 33(3),16,1968
unreported route
rat 		lethal dose (50 percent kill): 13 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting 		GISAAA 33(3),16,1968
unreported route
rabbit 		lethal dose (50 percent kill): 5,017 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting 		GISAAA 33(3),16,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 500,000 mg/m3/6 hour/28 hour- intermittent Brain and Coverings: Other degenerative changes

Behavioral: General anesthetic 		VCVGK* -,140,1994
inhalation
guinea pig 		lowest published toxic concentration: 1 mg/m3/122 day- intermittent Eye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough 		VCVGK* -,140,1994
inhalation
guinea pig 		lowest published toxic concentration: 1 mg/m3/154 day- intermittent Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		VCVGK* -,140,1994
inhalation
human 		lowest published toxic concentration: 140 mg/m3/30 day- intermittent Lung, Thorax, or Respiration: Cough VCVGK* -,140,1994
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 256 mg/m3/28 day- intermittent Liver: Liver function tests impaired VCVGK* -,140,1994
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 20 mg/m3/5 year- intermittent Cardiac: Other changes

Vascular: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,141,1994
inhalation
monkey 		lowest published toxic concentration: 500,000 mg/m3/6 hour/28 hour- intermittent Brain and Coverings: Other degenerative changes

Behavioral: General anesthetic 		VCVGK* -,140,1994
inhalation
mouse 		lowest published toxic concentration: 10 mg/m3/122 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,140,1994
inhalation
mouse 		lowest published toxic concentration: 1 mg/m3/122 day- intermittent Eye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough 		VCVGK* -,140,1994
inhalation
mouse 		lowest published toxic concentration: 1 mg/m3/154 day- intermittent Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		VCVGK* -,140,1994
inhalation
rat 		lowest published toxic concentration: 8,400 µg/m3/24 hour/12 week- continuous Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 39(9),106,1974
inhalation
rat 		lowest published toxic concentration: 12 mg/m3/8 hour/90 day- intermittent Eye: Corneal damage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 16,646,1970
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/32 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		TPKVAL 7,102,1965
inhalation
rat 		lowest published toxic concentration: 120 mg/m3/8 day- intermittent Eye: Corneal damage VCVGK* -,140,1994
inhalation
rat 		lowest published toxic concentration: 198 mg/m3/4 hour/122 day- intermittent Cardiac: Other changes

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,140,1994
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/122 day- intermittent Eye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough 		VCVGK* -,140,1994
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/154 day- intermittent Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		VCVGK* -,140,1994
inhalation
rabbit 		lowest published toxic concentration: 12 mg/m3/8 hour/90 day- intermittent Eye: Corneal damage

Eye: Other eye effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 16,646,1970
oral
monkey 		lowest published toxic dose: 5,751 gm/kg/22 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 15,624,1969
oral
mouse 		lowest published toxic dose: 546 gm/kg/13 week- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-413,1993
oral
mouse 		lowest published toxic dose: 1,081 gm/kg/2 year- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		NTPTR* NTP-TR-413,1993
oral
mouse 		lowest published toxic dose: 88,720 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 29.4 gm/kg/7 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 81,100,1985
oral
mouse 		lowest published toxic dose: 117.6 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 81,100,1985
oral
mouse 		lowest published toxic dose: 82.3 gm/kg/14 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 81,100,1985
oral
mouse 		lowest published toxic dose: 15,000 mg/kg/10 day- continuous Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight 		NTIS** #PB85-105385
oral
mouse 		lowest published toxic dose: 294,000 mg/kg/15 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB86177383
oral
rat 		lowest published toxic dose: 14 mL/kg/2 week- continuous Liver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		JOUOD4 13,13,1991
oral
rat 		lowest published toxic dose: 438 gm/kg/2 year- continuous Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FCTXAV 3,229,1965
oral
rat 		lowest published toxic dose: 85,230 mg/kg/90 day- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: P 		DCTODJ 13,43,1990
oral
rat 		lowest published toxic dose: 12 mL/kg/6 day- intermittent Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TXAPA9 39,543,1977
oral
rat 		lowest published toxic dose: 26,150 mg/kg/10 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		DCTODJ 13,43,1990
oral
rat 		lowest published toxic dose: 33,750 mg/kg/15 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Maternal effects: Uterus, cervix, vagina 		NTIS** #PB85-105385
oral
rat 		lowest published toxic dose: 18,750 mg/kg/15 day- intermittent Kidney, Ureter, and Bladder: Other changes NTIS** #PB85-105385
oral
rat 		lowest published toxic dose: 25,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB95-274528
oral
rabbit 		lowest published toxic dose: 28,000 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** #PB91-211219
unreported route
rat 		lowest published toxic dose: 9.1 mg/kg/26 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		VCVGK* -,141,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 100 mg/m3 ( hour) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
REPTED 8,99,1994
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,308,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 (particulate) DTLWS* 3,19,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 60 mg/m3, short term exposure limit 120 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (26 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 50 ppm (127 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (130 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1993
Occupational Exposure Limit - FRANCE VLE 50 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (26 mg/m3), Skin, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 50 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 52 mg/m3 (fume), 2003
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3 (drops), 2003
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (63 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 50 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 10 ppm (25 mg/m3), KTV 20 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, Particulate, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 60 mg/m3, short term exposure limit 125 mg/m3, Vapor, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 100 mg/m3 ( hour)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 100 mg/m3 ( hour)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 32385;
Number of Industries 308;
Total Number of Facilities 69,314;
Number of Occupations 174;
Total Number of Employees Exposed 743,782
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 32385;
Number of Industries 340;
Total Number of Facilities 102,395;
Number of Occupations 214;
Total Number of Employees Exposed 1,511,087;
Total Number of Female Employees Exposed 446,607


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101108/AS)
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in antifreeze and in production of POLYETHYLENE TEREPHTHALATE fibers and films
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9100;8EHQ-0892-9252
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylene glycol, 5500
NIOSH Analytical Method, 1996: Glycols, 5523
NCI Carcinogenesis Studies (feed);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
BUYRAI Bulletin of Parenteral Drug Association. (Philadelphia, PA) V.1-31, 1946-77.
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IAEHDW International Archives of Occupational and Environmental Health. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.35- 1975-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JOUOD4 Journal of UOEH (University of Occupational and Environmental Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
KRKRDT Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1975-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824-
SMEZA5 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1958-
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used in antifreeze and in production of POLYETHYLENE TEREPHTHALATE fibers and films

Top 50 chemical production: 5.12 billions lbs in 1992, 4.81 billions in 1991

NIOSH PROFILE (GLYCOLS), SRI, 2/77

NIOSH PROFILE (GLYCOLS), SRC, 2/82

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 71767-64-1
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