The Registry of Toxic Effects of Chemical Substances

Ethylamine, 2,2' - oxybis (N,N - dimethyl -

RTECS #: KR9460000

CAS #: 3033-62-3

UPDATE: May 2004 MW: 160.30 MF: C8H20N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. A 99 (Amine)
  2. Bis (2 - dimethylaminoethyl) ether
  3. Dabco BL 11
  4. Dabco BL 19
  5. Dabco BL 19I
  6. Kalpur PC
  1. Niax A 1
  2. Niax A 99
  3. Texacat ZF 20
  4. Toyocat ET
  5. Toyocat ETS
  6. 2,2' - Oxybis (N,N - dimethylethylamine)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg severe UCDS** 12/27/1971
eye
rabbit 		250 µg/24 hour severe 85JCAE -,721,1986
skin
rabbit 		5 mg/24 hour severe 85JCAE -,721,1986
skin
rabbit 		500 mg open irritation test severe UCDS** 12/27/1971
skin
rabbit 		100 mg/24 hour severe JTOTDO 5,3,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		lowest published toxic dose: 650 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JTOTDO 5,263,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 117 ppm/6 hour Eye: Corneal damage

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes 		NTIS** OTS0536387
oral
rat 		lethal dose (50 percent kill): 571 mg/kg N/R NTIS** OTS0545161
skin
rabbit 		lethal dose (50 percent kill): 280 µL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 ppm/6 hour/9 day- intermittent Olfaction: Other olfaction effects

Eye: Ptosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0536526
oral
rat 		lowest published toxic dose: 1,540 mg/kg/7 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0536157
skin
rabbit 		lowest published toxic dose: 292 mg/kg/11 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTOTDO 5,3,1986
skin
rabbit 		lowest published toxic dose: 391 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, other JTOTDO 5,3,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin);short term exposure limit 0.15 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.15 ppm (skin) DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BIS(2-(DIMETHYlAMINO)ETHYL)ETHER-air minimize exposure NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0015;
Number of Industries 1;
Total Number of Facilities 8;
Number of Occupations 2;
Total Number of Employees Exposed 40
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0015;
Number of Industries 2;
Total Number of Facilities 60;
Number of Occupations 5;
Total Number of Employees Exposed 1,529;
Total Number of Female Employees Exposed 165


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of polyurethane foams
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 26, 1978


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in the manufacture of polyurethane foams

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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