The Registry of Toxic Effects of Chemical Substances

Ether, diphenyl

RTECS #: KN8970000

CAS #: 101-84-8

UPDATE: August 2004 MW: 170.22 MF: C12H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzene, 1,1' - oxybis - (9CI)
  2. Benzene, phenoxy -
  3. Biphenyl oxide
  4. Chemcryl JK - EB
  5. Diphenyl ether
  6. Diphenyl oxide
  7. Geranium crystals
  1. Oxybisbenzene
  2. Oxydiphenyl
  3. Phenoxybenzene
  4. Phenyl ether (ACGIH:OSHA)
  5. Phenyl ether, fume
  6. Phenyl oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rat 		10 ppm/140 hour N/R TXAPA9 33,78,1975
eye
rabbit 		10 ppm/140 hour N/R TXAPA9 33,78,1975
skin
rabbit 		500 mg/24 hour mild FCTXAV 12,707,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 2,450 mg/kg Behavioral: Food intake (animal)

Behavioral: Muscle weakness

Gastrointestinal: Other changes 		NTIS** 0TS0518143
oral
rat 		lethal dose (50 percent kill): 4,000 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,303,1984
skin
rabbit 		lethal dose (50 percent kill): >7,940 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema 		NTIS** 0TS0518143


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 150 mg/kg/5 day- intermittent Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOXID9 72,135,2003
oral
rat 		lowest published toxic dose: 93 mg/kg/31 day- intermittent Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOXID9 72,135,2003
oral
rat 		lowest published toxic dose: 930 mg/kg/31 day- intermittent Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Reproductive: Other effects on male 		TOXID9 72,135,2003
oral
rat 		lowest published toxic dose: 1,860 mg/kg/31 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight 		TOXID9 72,135,2003
oral
rat 		lowest published toxic dose: 150 mg/kg/5 day- intermittent Liver: Liver function tests impaired

Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOXID9 72,136,2003
oral
rat 		lowest published toxic dose: 1,200 mg/kg/20 day- intermittent Reproductive: Other effects on female TOXID9 72,136,2003
skin
rat 		lowest published toxic dose: 27.3 gm/kg/6 hour/13 week- intermittent Liver: Changes in liver weight FCTOD7 41,259,2003
skin
rat 		lowest published toxic dose: 91 gm/kg/6 hour/13 week- intermittent Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		FCTOD7 41,259,2003
skin
rat 		lowest published toxic dose: 9.1 gm/kg/6 hour/13 week- intermittent Skin: After systemic exposure: Dermatitis, other FCTOD7 41,259,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm;short term exposure limit 2 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 2 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (7 mg/m3) (vapor) DTLVS* 3,205,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (7 mg/m3), short term exposure limit 2 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (7 mg/m3), short term exposure limit 2 ppm (14 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (7 mg/m3), short term exposure limit 3 ppm (21 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (7 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 7 mg/m3, MAC(short term exposure limit) 14 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 1 ppm (7 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL ETHER, vapor-air 10 hour time-weighted average 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 57210;
Number of Industries 17;
Total Number of Facilities 561;
Number of Occupations 33;
Total Number of Employees Exposed 13,791
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 57210;
Number of Industries 62;
Total Number of Facilities 7,313;
Number of Occupations 70;
Total Number of Employees Exposed 90,789;
Total Number of Female Employees Exposed 33,945


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a heat-transfer agent, as a chemical intermediate and in perfumery
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl ether, 1617


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a heat-transfer agent, as a chemical intermediate and in perfumery

NIOSH PROFILE (ORGANIC OXIDES OR EPOXY COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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