The Registry of Toxic Effects of Chemical Substances

Ether, 2,2 - dichloro - 1,1 - difluoroethyl methyl

RTECS #: KN7820000

CAS #: 76-38-0

UPDATE: February 2004 MW: 164.97 MF: C3H4Cl2F2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Analgizer
  2. Anecotan
  3. 2,2 - Dichloro - 1,1 - difluoroethyl methyl ether
  4. Ethane, 2,2 - dichloro - 1,1 - difluoro - 1 - methoxy -
  5. Ingalan
  6. Inhalan
  7. Methoflurane
  8. Methoxane
  9. Methoxyfluran
  1. Methoxyflurane
  2. Metofane
  3. Metoxfluran
  4. Metoxifluran
  5. Penthrane
  6. Pentran
  7. Pentrane
  8. NSC - 110432


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg moderate FEPRA7 35,729,1976


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
chicken 		10 mg ENVRAL 12,366,1976
cytogenetic analysis human lymphocyte 200 ppm/24 hour ENVRAL 12,366,1976
cytogenetic analysis mouse fibroblast 100 ppm ENVRAL 12,366,1976
other mutation test systems hamster fibroblast 1 pph ANESAV 43,21,1975
other mutation test systems inhalation
rat 		5,000 ppm/3 hour- continuous EXPEAM 35,71,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 2 ppm/4 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system AACRAT 59,421,1980
inhalation
mouse 		lowest published toxic concentration: 2,000 ppm/4 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		AACRAT 59,421,1980
inhalation
rat 		lowest published toxic concentration: 100 ppm/8 hour (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ANESAV 48,11,1978
inhalation
rat 		lowest published toxic concentration: 400 ppm/8 hour (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ANESAV 48,11,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 3 pph Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration

Endocrine: Hyperglycemia 		VCVGK* -,286,1994
inhalation
human 		lowest published toxic concentration: 3,500 ppm/1 hour Kidney, Ureter, and Bladder: Renal function tests depressed CANJAE 21,294,1974
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 34 gm/m3 Behavioral: Antipsychotic GTPZAB 24(4),55,1980
inhalation
mouse 		lethal concentration (50 percent kill): 21,500 mg/m3 Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement 		GTPZAB 22(7),55,1978
inhalation
mouse 		lethal concentration (50 percent kill): 122,600 mg/m3/4 hour N/R VCVGK* -,286,1994
inhalation
rat 		lethal concentration (50 percent kill): 33,500 mg/m3/4 hour N/R 85GMAT -,53,1982
inhalation
rat 		lowest published toxic concentration: 0.5 pph/2 hour Behavioral: Food intake (animal)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		VCVGK* -,286,1994
intravenous
mouse 		lethal dose (50 percent kill): 150 mg/kg N/R USXXAM #4168308
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 3,600 mg/kg Behavioral: Antipsychotic GTPZAB 24(4),55,1980
oral
rat 		lethal dose (50 percent kill): 3.6 mg/kg N/R VCVGK* -,286,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 48,600 mg/m3/4 hour/30 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Endocrine: Adrenal cortex hyperplasia 		VCVGK* -,286,1994
inhalation
rat 		lowest published toxic concentration: 50 ppm/24 hour/14 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		APTOA6 57,176,1985
inhalation
rat 		lowest published toxic concentration: 48,600 mg/m3/4 hour/30 day- intermittent Liver: Other changes FATOAO 35,271,1972
inhalation
rat 		lowest published toxic concentration: 1,100 mg/m3/60 day- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,286,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMSUDL 7,93,1987
TOXICOLOGY REVIEW
ARPTDI 16,67,1976
TOXICOLOGY REVIEW
KDYIA5 10,82,1976
TOXICOLOGY REVIEW
CANJAE 19,152,1972
TOXICOLOGY REVIEW
ARMCAH 25,411,1974
TOXICOLOGY REVIEW
AACRAT 57,328,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (14 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 200 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHOXYFLURANE-air ceiling concentration 2 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82904;
Number of Industries 2;
Total Number of Facilities 627;
Number of Occupations 6;
Total Number of Employees Exposed 8,095
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82904;
Number of Industries 2;
Total Number of Facilities 2,120;
Number of Occupations 14;
Total Number of Employees Exposed 32,772;
Total Number of Female Employees Exposed 18,210


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1950-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
CANJAE Canadian Anaesthetists' Society Journal. (Toronto, Ont., Canada) V.1-33, 1954-86.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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