The Registry of Toxic Effects of Chemical Substances

Ether, 1 - chloro - 2,2,2 - trifluoroethyl difluoromethyl

RTECS #: KN6799000

CAS #: 26675-46-7

UPDATE: May 2005 MW: 184.50 MF: C3H2ClF5O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (+ - ) - Isoflurane
  2. 2 - Chloro - 2 - (difluoromethoxy) - 1,1,1 - trifluoroethane
  3. Ethane, 2 - chloro - 2 - (difluoromethoxy) - 1,1,1 - trifluoro - (9CI)
  4. Forane
  1. ISF
  2. Isoflurane
  3. R - E 235dal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage inhalation
human 		1 pph/2 hour MUREAV 492,99,2001
micronucleus test oral
rat 		4 mmol/kg MUREAV 413,1,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 6,000 ppm/4 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		TJADAB 29(2),54A,1984
inhalation
rat 		lowest published toxic concentration: 10,500 ppm/6 hour (14-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ANESAV 64,339,1986
inhalation
rat 		lowest published toxic concentration: 4,000 ppm/3 hour (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) KSRNAM 21,3091,1987
inhalation
rat 		lowest published toxic dose: 12,000 ppm/3 hour (17-20 day pregnant/21 day after birth) Reproductive: Effects on newborn: Physical KSRNAM 21,3109,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 1.8 pph Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Vascular: Other changes 		AANEAB 45,971,2001
inhalation
mouse 		lethal concentration (50 percent kill): 16,800 ppm/3 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		KSRNAM 21,3031,1987
inhalation
rat 		lethal concentration (50 percent kill): 15,300 ppm/3 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		KSRNAM 21,3031,1987
inhalation
rat 		lowest published toxic concentration: 1 pph/30 minute Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other 		AANEAB 46,378,2002
inhalation
rat 		lowest published toxic concentration: 1.2 pph/30 minute Behavioral: Analgesia AANEAB 46,451,2002
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,030 無/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		KSRNAM 21,3031,1987
intraperitoneal
rat 		lethal dose (50 percent kill): 4,280 無/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		KSRNAM 21,3031,1987
oral
man 		lowest published lethal dose: 1,143 無/kg Brain and Coverings: Changes in surface EEG

Behavioral: Muscle weakness

Blood: Changes in leukocyte (WBC) count 		NLJMAV 33,74,1988
oral
man 		lowest published lethal dose: 1,071 無/kg N/R JFSCAS 38,968,1993
oral
mouse 		lethal dose (50 percent kill): 5,080 無/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		KSRNAM 21,3031,1987
oral
rat 		lethal dose (50 percent kill): 4,770 無/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		KSRNAM 21,3031,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 1,500 ppm/24 hour/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ANESAV 42,408,1975
inhalation
mouse 		lowest published toxic concentration: 150 ppm/24 hour/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ANESAV 42,408,1975
inhalation
rat 		lowest published toxic concentration: 12,000 ppm/3 hour/10 week- intermittent Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		KSRNAM 21,3037,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMSUDL 7,93,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (80 mg/m3), short term exposure limit 20 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (383 mg/m3), SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 153 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3787;
Number of Industries 2;
Total Number of Facilities 1,009;
Number of Occupations 7;
Total Number of Employees Exposed 33,152;
Total Number of Female Employees Exposed 27,151


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
Used as an anesthetic
OSHA ANALYTICAL METHOD #103


REFERENCES:

CODEN
REFERENCE
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JFSCAS Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NLJMAV Netherlands Journal of Medicine. (Elsevier Science, POB 211, 1000 AE Amsterdam. Netherlands) V.16- 1973-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

Used as an anesthetic

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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