The Registry of Toxic Effects of Chemical Substances

Ether, chloromethyl methyl

RTECS #: KN6650000

CAS #: 107-30-2

UPDATE: May 2005 MW: 80.52 MF: C2H5ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. CMME
  2. Chlordimethylether (Czech)
  3. Chloromethyl methyl ether
  4. Chloromethyl methyl ether (ACGIH:OSHA)
  5. Chloromethyl methyl ether, technical grade
  6. Dimethylchloroether
  1. Ether methylique monochlore (French)
  2. Ether, dimethyl chloro
  3. Methoxychloromethane
  4. Methylchloromethyl ether
  5. Monochlorodimethyl ether
  6. RCRA waste number U046


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human lymphocyte 5 mL/L CALEDQ 13,213,1981
morphological transform hamster embryo 10 mg/L AETODY 1,241,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 1 ppm/6 hour/90 day Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		AEHLAU 30,70,1975
inhalation
mouse 		lowest published toxic concentration: 2 ppm/82 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		AEHLAU 22,663,1971
inhalation
rat 		lowest published toxic concentration: 1 ppm/6 hour/72 week Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors 		AEHLAU 30,70,1975
subcutaneous
mouse 		lowest published toxic dose: 312 mg/kg/26 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 46,143,1971
subcutaneous
mouse 		toxic dose : 852 mg/kg/71 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 48,1431,1972
subcutaneous
mouse 		toxic dose : 125 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		TXAPA9 15,92,1969


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lethal concentration (50 percent kill): 65 ppm/7 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage 		AEHLAU 30,61,1975
inhalation
hamster 		lethal concentration (50 percent kill): 212.5 mg/m3/7 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,278,1994
inhalation
mouse 		lethal concentration (50 percent kill): 1,030 mg/m3/2 hour N/R 85GMAT -,89,1982
inhalation
mouse 		lowest published lethal concentration: 330 mg/m3/2 hour N/R VCVGK* -,278,1994
inhalation
rat 		lethal concentration (50 percent kill): 55 ppm/7 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage 		AEHLAU 30,61,1975
inhalation
rat 		lethal concentration (50 percent kill): 179.8 mg/m3/7 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,278,1994
inhalation
rabbit 		lowest published toxic concentration: 9 mg/m3 Lung, Thorax, or Respiration: Cough VCVGK* -,278,1994
inhalation
rabbit 		lowest published toxic concentration: 27 mg/m3 Behavioral: Alteration of classical conditioning VCVGK* -,278,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 6 mg/m3/130 day- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,278,1994
inhalation
rat 		lowest published toxic concentration: 32.7 mg/m3/30 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,278,1994
inhalation
rat 		lowest published toxic concentration: 3.27 mg/m3/130 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Skin and Appendages: Tumors 		VCVGK* -,278,1994
inhalation
rabbit 		lowest published toxic concentration: 3 mg/m3/5 hour/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,278,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average L DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 4,239,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 4,239,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,131,1987
TOXICOLOGY REVIEW
MUREAV 566,21,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1108 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) cancer suspect agent CFRGBR 29,1910.1006,1987
Occupational Exposure Limit - AUSTRALIA Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM Carcinogen, JAN1993
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND Carcinogen, JAN1999
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROMETHYL METHYL ETHER-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1006 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of other organic chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #10


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in synthesis of other organic chemicals

RTECS Compound Description:
   Tumorigen
   Mutagen

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