The Registry of Toxic Effects of Chemical Substances

Ether, tert - butyl methyl

RTECS #: KN5250000

CAS #: 1634-04-4

UPDATE: May 2005 MW: 88.17 MF: C5H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylethyl methyl ether
  2. 2 - Methoxy - 2 - methylpropane
  3. 2 - Methyl - 2 - methoxypropane
  4. 2 - Methyl - 2 - methoxypropane fume
  5. Methyl 1,1 - dimethylethyl ether
  6. Methyl t - butyl ether
  1. Methyl tert - butyl ether
  2. Methyl tert - butyl ether (ACGIH)
  3. Methyl tertiary butyl ether
  4. Propane, 2 - methoxy - 2 - methyl - (9CI)
  5. tert - Butoxymethane
  6. tert - Butyl methyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1,500 µg/plate (+enzymatic activation step) MUREAV 446,15,1999


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 4,000 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JJATDK 17(S1),S21,1997
inhalation
mouse 		lowest published toxic concentration: 8,000 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JJATDK 17(S1),S21,1997
inhalation
rat 		lowest published toxic concentration: 8,000 ppm/6 hour (multigeneration) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		JJATDK 17(S1),S13,1997
oral
mouse 		lowest published toxic dose: 6 gm/kg (5 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** OTS0559651


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 141 gm/m3/15 minute Behavioral: General anesthetic ANESAV 11,455,1950
inhalation
mouse 		lethal concentration (50 percent kill): 28,000 mg/m3/2 hour N/R VCVGK* -,268,1994
inhalation
rat 		lethal concentration (50 percent kill): 23,576 ppm/4 hour N/R NTIS** PB87-174603
inhalation
rat 		lethal concentration (50 percent kill): 41,000 mg/m3/4 hour N/R VCVGK* -,268,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,700 µL/kg N/R CHHTAT 70,172,1990
intraperitoneal
rat 		lethal dose : >148 mg/kg N/R JSGRA2 53,572,1992
intravenous
rat 		lowest published lethal dose: 148 mg/kg N/R JSGRA2 53,572,1992
oral
mouse 		lethal dose (50 percent kill): 5,960 µL/kg N/R CHHTAT 70,172,1990
oral
rat 		lethal dose (50 percent kill): 4 gm/kg N/R NTIS** PB87-174603
oral
rat 		lowest published toxic dose: 1,000 mg/kg Endocrine: Androgenic TOSCF2 71,31,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 180 mg/m3/6 hour/15 week- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		VCVGK* -,268,1994
inhalation
mouse 		lowest published toxic concentration: 8,000 ppm/3 day- continuous Reproductive: Maternal effects: Uterus, cervix, vagina TOSCF2 41,77,1998
inhalation
mouse 		lowest published toxic concentration: 8,000 ppm/21 day- continuous Endocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		TOSCF2 41,77,1998
inhalation
mouse 		lowest published toxic concentration: 8,000 ppm/16 week- continuous Endocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 41,77,1998
inhalation
mouse 		lowest published toxic concentration: 8,000 ppm/32 week- continuous Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Related to Chronic Data: Changes in uterine weight 		TOSCF2 41,77,1998
inhalation
rat 		lowest published toxic concentration: 1,516 ppm/6 hour/10 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 143,301,1997
oral
rat 		lowest published toxic dose: 49 gm/kg/28 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0540108
oral
rat 		lowest published toxic dose: 20 gm/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JACTDZ 9(5),525,1990
oral
rat 		lowest published toxic dose: 27 gm/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca 		JACTDZ 9(5),525,1990
oral
rat 		lowest published toxic dose: 15,000 mg/kg/15 day- intermittent Endocrine: Evidence of thyroid hyperfunction TOSCF2 54,168,2000
oral
rat 		lowest published toxic dose: 22,500 mg/kg/15 day- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration 		TOSCF2 54,168,2000
oral
rat 		lowest published toxic dose: 42,000 mg/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration

Related to Chronic Data: Changes in testicular weight 		TOSCF2 54,168,2000
oral
rat 		lowest published toxic dose: 210 mg/kg/14 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 72,82,2003
oral
rat 		lowest published toxic dose: 4.2 gm/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 17,273,2003
oral
rat 		lowest published toxic dose: 11,200 mg/kg/28 day- intermittent Liver: Changes in liver weight

Endocrine: Androgenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 71,31,2003
oral
rat 		lowest published toxic dose: 7,500 mg/kg/11 day- intermittent Endocrine: Androgenic

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOSCF2 71,31,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 73,339,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,339,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,339,1999
TOXICOLOGY REVIEW
TOLED5 123,89,2001
TOXICOLOGY REVIEW
MUREAV 567,347,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (180 mg/m3), short term exposure limit 75 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (92 mg/m3), short term exposure limit 75 ppm (275 mg/m3), SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 180 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4267;
Number of Industries 6;
Total Number of Facilities 614;
Number of Occupations 9;
Total Number of Employees Exposed 5,996;
Total Number of Female Employees Exposed 1,783


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121016/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an organic solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl tert-butyl ether, 1615


REFERENCES:

CODEN
REFERENCE
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915- Suspended 1967-72.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an organic solvent

Top 50 chemical production: 10.86 billions lbs in 1992, 9.57 billions in 1991

NIOSH PROFILE (METHYL tert-BUTYL ETHER), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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