The Registry of Toxic Effects of Chemical Substances

Ether, bis (2 - ethoxyethyl)

RTECS #: KN3160000

CAS #: 112-36-7

UPDATE: August 2003 MW: 162.26 MF: C8H18O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Bis (2 - ethoxyethyl) ether
  2. Diethyl carbitol
  3. Diethylene glycol diethyl ether
  4. Diethylether diethylenglykolu (Czech)
  1. 1 - Ethoxy - 2 - (beta - ethoxyethoxy) ethane
  2. Ethyl diglyme
  3. 3,6,9 - Trioxaundecane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg moderate UCDS** 4/25/1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 24 gm/kg (7-14 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB88-168257
oral
mouse 		lowest published toxic dose: 24,000 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Other neonatal measures or effects 		EVHPAZ 57,141,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 1,850 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
oral
rat 		lethal dose (50 percent kill): 4,970 mg/kg N/R UCDS** 4/25/1958
skin
rabbit 		lethal dose (50 percent kill): 6,700 µL/kg N/R UCDS** 4/25/1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,200 mg/kg/4 day- intermittent Brain and Coverings: Other degenerative changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** #PB88-168257
oral
mouse 		lowest published toxic dose: 15,000 mg/kg/10 day- intermittent Behavioral: Sleep

Behavioral: Ataxia

Behavioral: Coma 		NTIS** #PB88-168257
oral
rabbit 		lowest published toxic dose: 4,000 mg/kg/14 day- intermittent Behavioral: Ataxia

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		NTIS** #PB88-168497
oral
rabbit 		lowest published toxic dose: 4,000 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB88-168497


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84038;
Number of Industries 7;
Total Number of Facilities 1,327;
Number of Occupations 8;
Total Number of Employees Exposed 3,060
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84038;
Number of Industries 3;
Total Number of Facilities 172;
Number of Occupations 5;
Total Number of Employees Exposed 3,489;
Total Number of Female Employees Exposed 2,128


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and in high boiling reaction medium
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a solvent and in high boiling reaction medium

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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