The Registry of Toxic Effects of Chemical Substances

Ether, bis (2,3 - epoxypropyl)

RTECS #: KN2350000

CAS #: 2238-07-5

UPDATE: November 2004 MW: 130.16 MF: C6H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. DGE (OSHA)
  2. Di (2,3 - epoxy) propyl ether
  3. Diglycidyl ether
  1. Diglycidyl ether (ACGIH:OSHA)
  2. Ether, diglycidyl


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		113 mg severe AMIHAB 14,250,1956
eye
rabbit 		750 µg/24 hour severe 85JCAE -,773,1986
skin
rabbit 		563 mg/3 day severe AMIHAB 14,250,1956
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,773,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 50 µg/plate (+/-enzymatic activation step) MUREAV 66,367,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
mouse 		lowest published toxic dose: 1,300 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 30 ppm/4 hour Lung, Thorax, or Respiration: Other changes AMIHAB 14,250,1956
inhalation
rat 		lethal concentration (50 percent kill): 200 ppm/4 hour N/R 85JCAE -,773,1986
intravenous
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R CSLNX* NX#00108
intravenous
rabbit 		lowest published lethal dose: 200 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Hepatitis (hepatocellular necrosis), diffuse 		AEHLAU 2,31,1961
oral
mouse 		lethal dose (50 percent kill): 170 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
oral
rat 		lethal dose (50 percent kill): 450 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
skin
rat 		lethal dose (50 percent kill): 1 gm/kg N/R 85JCAE -,773,1986
skin
rabbit 		lowest published lethal dose: 1,500 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, irritative 		AMIHAB 14,250,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2 ppm/4 hour/29 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in leukocyte (WBC) count 		AEHLAU 2,31,1961
skin
rat 		lowest published toxic dose: 2,500 mg/kg/4 week- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AEHLAU 2,31,1961


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.5 ppm (2.8 mg/m3) DTLVS* 3,86,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.5 ppm (2.8 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.5 ppm (2.8 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.5 ppm (2.8 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.5 ppm (2.8 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.5 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.6 mg/m3), Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.53 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.53 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.2 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.5 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.6 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 ppm (2.8 mg/m3), JAN1993
Occupational Exposure Limit - SWEDEN TGV 0.2 ppm (1.1 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.5 mg/m3), KZG- week 0.2 ppm (1.0 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.5 ppm (2.8 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 ppm (2.8 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.53 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIGLYCIDYL ETHER-air Carcinogen;
10 hour time-weighted average 0.1 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 12846;
Number of Industries 1;
Total Number of Facilities 29;
Number of Occupations 1;
Total Number of Employees Exposed 86


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.

NIOSH PROFILE (ETHERS, GLYCIDYL), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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