The Registry of Toxic Effects of Chemical Substances

Ether, bis (2 - chloro - 1 - methylethyl)

RTECS #: KN1750000

CAS #: 108-60-1

UPDATE: February 2004 MW: 171.08 MF: C6H12Cl2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. (2 - Chloro - 1 - methylethyl) ether
  2. 2,2' - Dichloroisopropyl ether
  3. 2,2' - Oxybis (1 - chloropropane)
  4. 2 - (1 - Methyl - 2 - chloroethoxy) - 1 - chloropropane
  5. 2 - (1 - Methyl - 2 - chloroethoxy) - 1 - chloropropane, fume
  6. Bis (1 - chloro - 2 - propyl) ether
  7. Bis (2 - chloro - 1 - methylethyl) ether
  8. Bis (2 - chloroisopropyl) ether
  9. Bis (beta - chloroisopropyl) ether
  10. DCIP
  11. DCIP (nematocide)
  1. Dichlorodiisopropyl ether
  2. Dichloroisopropyl ether
  3. Isopropylchlorex
  4. NCI - C50044
  5. Nemamol
  6. Nemamort
  7. Nemamorte
  8. Propane, 2,2' - oxybis (1 - chloro -
  9. RCRA waste number U027
  10. beta,beta' - Dichlorodiisopropyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 124 mg/L EMMUEG 10(Suppl 10),1,1987
mutation in microorganisms Salmonella typhimurium 1 gm/plate (+enzymatic activation step) DHEFDK FDA-78-1046,1978
mutation in microorganisms Salmonella typhimurium 333 µg/plate (-enzymatic activation step) ENMUDM 8(Suppl 7),1,1986
mutation in mammalian somatic cells mouse lymphocyte 250 mg/L EMMUEG 12,85,1988
sister chromatid exchange hamster ovary 11,300 µg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 103,000 mg/kg/180 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** PB83-169615
oral
mouse 		lowest published toxic dose: 103,000 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB83-169615


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 700 ppm/5 hour Eye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes 		BJIMAG 27,1,1970
inhalation
rat 		lowest published lethal concentration: 5,700 mg/m3/1 hour Eye: Conjunctiva irritation

Behavioral: Ataxia 		VCVGK* -,284,1994
inhalation
rat 		lowest published lethal concentration: 700 mg/m3/5 hour Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,284,1994
inhalation
rat 		lowest published lethal concentration: 400 mg/m3/6 hour Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,284,1994
inhalation
rat 		lowest published lethal concentration: 240 mg/m3/8 hour Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,284,1994
oral
mouse 		lethal dose (50 percent kill): 296 mg/kg N/R YKYUA6 37,597,1986
oral
mouse 		lethal dose (50 percent kill): 1,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Liver: Hepatitis (hepatocellular necrosis), zonal 		VCVGK* -,284,1994
oral
rat 		lethal dose (50 percent kill): 240 mg/kg N/R AMIHBC 4,119,1951
oral
rat 		lethal dose (50 percent kill): 1,300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Liver: Hepatitis (hepatocellular necrosis), zonal 		VCVGK* -,284,1994
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,83,1991
skin
rabbit 		lethal dose (50 percent kill): 3 mL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 4,424 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-239,1982
oral
mouse 		lowest published toxic dose: 876 gm/kg/2 year- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTSCDR 2,295,1977
oral
mouse 		lowest published toxic dose: 873,600 mg/kg/104 week- continuous Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		VCVGK* -,285,1994
oral
rat 		lowest published toxic dose: 11,250 mg/kg/45 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		GISAAA 50(5),69,1985
oral
rat 		lowest published toxic dose: 2,340 mg/kg/26 week- intermittent Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		GISAAA 50(5),69,1985
oral
rat 		lowest published toxic dose: 364 gm/kg/2 year- continuous Behavioral: Food intake (animal)

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTSCDR 2,296,1977
oral
rat 		lowest published toxic dose: 11,250 mg/kg/45 day- intermittent Brain and Coverings: Changes in brain weight

Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVGK* -,284,1994
oral
rat 		lowest published toxic dose: 2,250 mg/kg/45 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		VCVGK* -,284,1994
oral
rat 		lowest published toxic dose: 660 mg/kg/152 day- intermittent Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,284,1994
oral
rat 		lowest published toxic dose: 228 mg/kg/152 day- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,285,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 41,149,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1275,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 41,149,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1275,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1275,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);no evidence:rat NCITR* NCI-TR-191,1979


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DHEFDK HEW Publication (FDA. United States). (Washington, DC) ?-1979(?). For publisher information, see HPFSDS.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a chemical intermediate

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

ALT CAS #: 52438-91-2
 Click Here for Additional Information about RTECS