The Registry of Toxic Effects of Chemical Substances

Ether, bis (chloromethyl)

RTECS #: KN1575000

CAS #: 542-88-1

UPDATE: May 2005 MW: 114.96 MF: C2H4Cl2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1' - Dichlorodimethyl ether
  2. BCME
  3. Bis (chloromethyl) ether (ACGIH:OSHA)
  4. Bis - CME
  5. Bis - chloromethyl - ether
  6. Chloro (chloromethoxy) methane
  7. Chloro (chloromethoxy) methane fume
  8. Chloromethyl ether
  1. Dichlordimethylaether (German)
  2. Dimethyl - 1,1' - dichloroether
  3. Methane, oxybis (chloro -
  4. Oxybis (chloromethane)
  5. RCRA waste number P016
  6. sym - Dichloro - dimethyl ether
  7. sym - Dichloromethyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition skin
mouse 		360 µmol/kg CNREA8 33,769,1973
unscheduled DNA synthesis human fibroblast 160 µg/L TXCYAC 21,151,1981
unscheduled DNA synthesis skin
mouse 		360 µmol/kg CNREA8 33,769,1973
mutation in microorganisms Salmonella typhimurium 20 µg/plate (-enzymatic activation step) BJCAAI 37,873,1978
morphological transform hamster kidney 80 µg/L BJCAAI 37,873,1978
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 100 ppb/6 hour/26 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		TXAPA9 58,269,1981
inhalation
mouse 		toxic concentration (other than lowest) : 1 ppm/82 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Increased incidence of tumors in susceptible strains 		AEHLAU 22,663,1971
inhalation
rat 		lowest published toxic concentration: 100 ppb/6 hour/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors 		AEHLAU 30,73,1975
inhalation
rat 		toxic concentration (other than lowest) : 100 ppb/6 hour/6 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		PAACA3 21,106,1980
inhalation
rat 		toxic concentration (other than lowest) : 100 ppb/6 hour/26 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors 		TXAPA9 58,269,1981
inhalation
rat 		toxic concentration (other than lowest) : 75 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors 		JJIND8 68,597,1982
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg/61 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		CNREA8 35,2553,1975
subcutaneous
mouse 		lowest published toxic dose: 384 mg/kg/42 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		CNREA8 40,352,1980
subcutaneous
mouse 		toxic dose : 640 mg/kg/53 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		CNREA8 35,2553,1975
subcutaneous
mouse 		toxic dose : 12,500 µg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Other: Hair 		TXAPA9 15,92,1969
subcutaneous
rat 		lowest published toxic dose: 375 mg/kg/43 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 43,481,1969
skin
mouse 		lowest published toxic dose: 5,520 mg/kg/23 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		AEHLAU 16,472,1968
skin
mouse 		toxic dose : 11 gm/kg/44 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 43,481,1969


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lethal concentration (50 percent kill): 7 ppm/7 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage 		AEHLAU 30,61,1975
inhalation
hamster 		lethal concentration (50 percent kill): 33 mg/m3/7 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,280,1994
inhalation
human 		lowest published toxic concentration: 14 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,280,1994
inhalation
human 		lowest published lethal concentration: 470 mg/m3/1 minute Lung, Thorax, or Respiration: Other changes VCVGK* -,280,1994
inhalation
man 		lowest published toxic concentration: 3 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		TJSGA8 51,596,1973
inhalation
man 		lowest published lethal concentration: 100 ppm/3 minute Lung, Thorax, or Respiration: Other changes TJSGA8 51,596,1973
inhalation
mouse 		lethal concentration (50 percent kill): 25 mg/m3/6 hour N/R AEHLAU 22,663,1971
inhalation
mouse 		lethal concentration (50 percent kill): 35 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,279,1994
inhalation
rat 		lethal concentration (50 percent kill): 7 ppm/7 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage 		AEHLAU 30,61,1975
inhalation
rat 		lethal concentration (50 percent kill): 218 mg/m3/30 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,279,1994
inhalation
rat 		lethal concentration (50 percent kill): 14 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,279,1994
inhalation
rat 		lethal concentration (50 percent kill): 33 mg/m3/7 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,280,1994
oral
rat 		lethal dose (50 percent kill): 210 µL/kg N/R AIHAAP 30,470,1969
skin
mammal (species unspecified) 		lowest published toxic dose: 2 pph Skin and Appendages: Tumors VCVGK* -,280,1994
skin
rabbit 		lethal dose (50 percent kill): 280 µL/kg N/R AIHAAP 30,470,1969
skin
rabbit 		lowest published toxic dose: 100 pph Skin: After topical application: Corrosive VCVGK* -,280,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 0.5 mg/m3/6 hour/210 day- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,280,1994
inhalation
mouse 		lowest published toxic concentration: 6 mg/m3/130 day- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,280,1994
inhalation
mouse 		lowest published toxic concentration: 5 mg/m3/28 week- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,280,1994
inhalation
rat 		lowest published toxic concentration: 4.7 mg/m3/30 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,280,1994
inhalation
rat 		lowest published toxic concentration: 0.5 mg/m3/6 hour/210 day- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,280,1994
inhalation
rat 		lowest published toxic concentration: 0.5 mg/m3/659 day- intermittent Olfaction: Tumors

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,280,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.001 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 4,231,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 4,231,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,131,1987
TOXICOLOGY REVIEW
MUREAV 566,21,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1108 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) cancer suspect agent CFRGBR 29,1910.1008,1987
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.001 ppm (0.006 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.001 ppm (0.0047 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.001 ppm (0.005 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.001 ppm (0.004 mg/m3), short term exposure limit 0.003 ppm, Carcinogen,JAN1999
Occupational Exposure Limit - FRANCE VME 0.001 ppm (0.006 mg/m3), continuous1 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - INDIA time-weighted average 0.001 ppm (0.005 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.001 ppm (0.005 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.001 ppm (0.005 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.001 ppm (0.005 mg/m3), Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BIS(CHLOROMETHYL) ETHER-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1008 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6315;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 14;
Total Number of Female Employees Exposed 5


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/168691/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of other organic chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #10


REFERENCES:

CODEN
REFERENCE
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
TJSGA8 Tijdschrift Voor Sociale Geneeskunde. (B.V. Uitgeversmaatschappij. Reflex, Mathenesserlaan 310, Rotterdam 3003, Netherlands) V.1- 1923-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in synthesis of other organic chemicals

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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