The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - propoxy -

RTECS #: KM2800000

CAS #: 2807-30-9

UPDATE: November 2004 MW: 104.17 MF: C5H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Ektasolve EP
  2. Ethylene glycol mono - n - propyl ether
  3. Monopropyl ether of ethylene glycol
  1. 2 - Propoxyethanol
  2. Propyl cellosolve
  3. Ethylene glycol mono propyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe EVHPAZ 57,165,1984
eye
rabbit 		750 µg/24 hour severe 85JCAE -,628,1986
skin
guinea pig 		500 mg mild EVHPAZ 57,165,1984
skin
rabbit 		500 mg/24 hour mild 85JCAE -,628,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 32,93,1985
inhalation
rat 		lowest published toxic concentration: 400 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** OTS0571682
oral
mouse 		lowest published toxic dose: 16 gm/kg (7-14 day pregnant) Reproductive: Effects on newborn: Stillbirth NTIS** PB86-197605


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 1,530 ppm/7 hour Behavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria 		JIHTAB 25,157,1943
inhalation
rat 		lowest published lethal concentration: 2,000 ppm/4 hour N/R JIHTAB 31,343,1949
inhalation
rat 		lethal concentration (50 percent kill): 9,060 mg/m3 N/R VCVGK* -,164,1984
oral
mouse 		lethal dose (50 percent kill): 1,774 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0570960
oral
rat 		lethal dose (50 percent kill): 3,089 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		EVHPAZ 57,165,1984
oral
rat 		lethal dose (50 percent kill): 3,090 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition 		VCVGK* -,164,1984
skin
guinea pig 		lethal dose (50 percent kill): 1 gm/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		EVHPAZ 57,165,1984
skin
rabbit 		lethal dose (50 percent kill): 960 µL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,164,1994
inhalation
rat 		lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent Endocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count 		EVHPAZ 57,165,1984
inhalation
rat 		lowest published toxic concentration: 425 mg/m3/6 hour/10 day- intermittent Blood: Changes in erythrocyte (RBC) count VCVGK* -,164,1994
inhalation
rabbit 		lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,164,1994
oral
rat 		lowest published toxic dose: 11,700 mg/kg/6 week- intermittent Kidney, Ureter, and Bladder: Hematuria

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		EVHPAZ 57,165,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (110 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 44 mg/m3, Skin, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3118;
Number of Industries 73;
Total Number of Facilities 11,635;
Number of Occupations 26;
Total Number of Employees Exposed 73,812
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3118;
Number of Industries 80;
Total Number of Facilities 10,270;
Number of Occupations 68;
Total Number of Employees Exposed 99,040;
Total Number of Female Employees Exposed 17,756


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS