The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - (2 - (2 - methoxyethoxy) ethoxy) -

RTECS #: KL6390000

CAS #: 112-35-6

UPDATE: December 2000 MW: 164.23 MF: C7H16O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Dowanol TMAT
  2. 2 - (2 - (2 - Methoxyethoxy) ethoxy) ethanol
  3. Methoxytriglycol
  4. Poly - Solv TM
  1. Triethylene glycolmonomethyl ether
  2. Triglycol monomethyl ether
  3. 3,6,9 - Trioxa - 1 - decanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,634,1986
skin
rabbit 		10 mg/24 hour open irritation test mild AIHAAP 23,95,1962
skin
rabbit 		500 mg/24 hour mild 85JCAE -,634,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 360 gm/kg (90 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** OTS0526404-2
oral
rat 		lowest published toxic dose: 111 gm/kg (6-21 day pregnant/21 day after birth) Reproductive: Other effects on female NTIS** OTS0526404-2


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 11,300 µL/kg N/R AIHAAP 23,95,1962
skin
rabbit 		lethal dose (50 percent kill): 7,100 µL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 36,400 mg/kg/13 week- continuous Liver: Other changes IJTOFN 17,1,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0892;
Number of Industries 85;
Total Number of Facilities 13,261;
Number of Occupations 32;
Total Number of Employees Exposed 80,404
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0892;
Number of Industries 22;
Total Number of Facilities 2,416;
Number of Occupations 29;
Total Number of Employees Exposed 18,956;
Total Number of Female Employees Exposed 9,842


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as chemical intermediate, reaction media, solvent for paints, lacquers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as chemical intermediate, reaction media, solvent for paints, lacquers and resins

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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