The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - (2 - methoxyethoxy) -

RTECS #: KL6125000

CAS #: 111-77-3

UPDATE: November 2004 MW: 120.17 MF: C5H12O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Diethylene glycol methyl ether
  2. Diethylene glycol monomethyl ether
  3. Diglycol monomethyl ether
  4. Dowanol 16
  5. Dowanol DM
  6. MECB
  7. Methoxydiglycol
  1. 2 - (2 - Methoxyethoxy) ethanol
  2. beta - Methoxy - beta' - hydroxydiethyl ether
  3. Methyl carbitol
  4. Methyl karbitol (Czech)
  5. Ethylene diglycol monomethyl ether
  6. Poly - Solv DM


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg moderate UCDS** 4/21/1967
eye
rabbit 		500 mg/24 hour mild 85JCAE -,628,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 32 gm/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 32,000 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		EVHPAZ 57,141,1984
oral
rat 		lowest published toxic dose: 19,800 mg/kg (7-17 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		AECTCV 24,228,1993
oral
rat 		lowest published toxic dose: 21,650 mg/kg (7-16 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		FAATDF 6,430,1986
oral
rat 		lowest published toxic dose: 19,800 mg/kg (7-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system 		AECTCV 24,228,1993
oral
rat 		lowest published toxic dose: 6,600 mg/kg (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Physical 		AECTCV 24,228,1993
skin
rabbit 		lowest published toxic dose: 3,250 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 7,68,1986
skin
rabbit 		lowest published toxic dose: 13 gm/kg (6-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		NTIS** OTS0520312


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >2 gm/m3/1 hour N/R NTIS** OTS0516703
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,611 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis 		GNAMAP 29,37,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 2,722 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis 		GNAMAP 29,37,1990
oral
guinea pig 		lethal dose (50 percent kill): 4,160 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
oral
mouse 		lethal dose (50 percent kill): 8,222 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis 		GNAMAP 29,37,1990
oral
rat 		lethal dose (50 percent kill): 4 mL/kg N/R NTIS** OTS0520737
oral
rabbit 		lethal dose (50 percent kill): 7,190 mg/kg N/R NTIS** OTS0516797
skin
guinea pig 		lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation VCVGK* -,173,1984
skin
rabbit 		lethal dose (50 percent kill): 2,500 µL/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		NTIS** OTS0516797


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 32,000 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
rat 		lowest published toxic dose: 107 gm/kg/6 week- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0570960
oral
rat 		lowest published toxic dose: 5,052 mg/kg/30 day- continuous Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other proteins 		GNAMAP 29,37,1990
oral
rat 		lowest published toxic dose: 40 gm/kg/4 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases 		TXCYAC 76,49,1992
oral
rat 		lowest published toxic dose: 40 gm/kg/20 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Related to Chronic Data: Changes in testicular weight 		BECTA6 44,602,1990
skin
guinea pig 		lowest published toxic dose: 65 gm/kg/13 week- intermittent Endocrine: Changes in spleen weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		FAATDF 6,339,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 45 mg/m3, Skin, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83736;
Number of Industries 67;
Total Number of Facilities 9,648;
Number of Occupations 47;
Total Number of Employees Exposed 59,491
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83736;
Number of Industries 134;
Total Number of Facilities 19,501;
Number of Occupations 89;
Total Number of Employees Exposed 290,501;
Total Number of Female Employees Exposed 50,151


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent, diluent for hydraulic brake fluids, and coalescing agent for paints
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as solvent, diluent for hydraulic brake fluids, and coalescing agent for paints

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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