The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - methoxy - , acetate

RTECS #: KL5950000

CAS #: 110-49-6

UPDATE: November 2004 MW: 118.15 MF: C5H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Methoxy - ethyl acetaat (Dutch)
  2. 2 - Methoxyaethylacetat (German)
  3. 2 - Methoxyethanol acetate
  4. 2 - Methoxyethanol, acetate
  5. 2 - Methoxyethyl acetate
  6. 2 - Methoxyethyl acetate (ACGIH:OSHA)
  7. 2 - Methoxyethyle, acetate de (French)
  8. 2 - Methoxyethylester kyseliny octove (Czech)
  9. 2 - Metossietilacetato (Italian)
  10. Acetate de l'ether monomethylique de l'ethylene - glycol (French)
  11. Acetate de methyle glycol (French)
  12. Acetato di metil cellosolve (Italian)
  13. Acetic acid 2 - methoxyethyl ester
  14. Aethylenglykolmethylaetheracetat (German)
  1. EGMEA
  2. Ethylene glycol methyl acetate (OSHA)
  3. Ethylene glycol methyl ether acetate
  4. Ethylene glycol monomethyl ether acetate
  5. Glycol ether EM acetate
  6. Glycol monomethyl ether acetate
  7. MeCsac
  8. Methyl cellosolve acetate
  9. Methyl cellosolve acetate (OSHA)
  10. Methyl cellosolye acetaat (Dutch)
  11. Methyl glycol acetate
  12. Methyl glycol monoacetate
  13. Methylcelosolvacetat (Czech)
  14. Methylglykolacetat (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		218 mg mild UCDS** 3/20/1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		32,000 ppm MUREAV 259,147,1991
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 56,600 ppm MUREAV 149,339,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 12,500 mg/kg (25 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct SAIGBL 21,29,1979
oral
mouse 		lowest published toxic dose: 50 gm/kg (25 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands SAIGBL 21,29,1979
oral
mouse 		lowest published toxic dose: 9,800 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** PB86-197605
oral
mouse 		lowest published toxic dose: 9,800 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 6 gm/m3/7 hour Eye: Lacrimation

Behavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of salivary glands 		AGGHAR 5,1,1933
inhalation
human 		lowest published toxic concentration: 1,000 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes 		AGGHAR 5,1,1933
inhalation
rat 		lowest published lethal concentration: 7,000 ppm/4 hour N/R JIHTAB 30,63,1948
intraperitoneal
rat 		lowest published lethal dose: 1,200 mg/kg Behavioral: General anesthetic

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Renal function tests depressed 		JPPMAB 11,150,1959
oral
guinea pig 		lethal dose (50 percent kill): 1,250 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
oral
mouse 		lethal dose (50 percent kill): 3,100 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (1),27,1996
oral
rat 		lethal dose (50 percent kill): 2,900 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (1),27,1996
subcutaneous
cat 		lowest published lethal dose: 3 gm/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		AGGHAR 5,1,1933
subcutaneous
guinea pig 		lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity) AGGHAR 5,1,1933
skin
rabbit 		lethal dose (50 percent kill): 5,250 µL/kg N/R UCDS** 3/20/1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CRTXB2 30,307,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (120 mg/m3) (skin) DTLVS* 3,159,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (120 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (120 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (120 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (120 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (24 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (25 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (24 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (24 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (120 mg/m3), short term exposure limit 40 ppm (180 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (24 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (25 mg/m3), Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 25 mg/m3, short term exposure limit 50 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1.5 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (120 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 25 mg/m3, MAC(short term exposure limit) 100 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 5 ppm, JAN1993
Occupational Exposure Limit - SWEDEN NGV 5 ppm (25 mg/m3), KTV 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (25 mg/m3), KZG- week 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (120 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (25 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGMEA-air 10 hour time-weighted average 0.1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46935;
Number of Industries 45;
Total Number of Facilities 2,907;
Number of Occupations 49;
Total Number of Employees Exposed 20,492
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46935;
Number of Industries 20;
Total Number of Facilities 658;
Number of Occupations 27;
Total Number of Employees Exposed 9,892;
Total Number of Female Employees Exposed 2,801


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl cellosolve acetate, 1451
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79


REFERENCES:

CODEN
REFERENCE
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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