The Registry of Toxic Effects of Chemical Substances
Ethanol, 2 - methoxy - |
UPDATE: November 2004 | MW: 76.11 | MF: C3H8O2 |
SYNONYMS: | |
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye guinea pig | 10 痢 | mild | JPPMAB 11,150,1959 |
eye rabbit | 97 mg | mild | TXAPA9 19,276,1971 |
eye rabbit | 500 mg/24 hour | mild | 85JCAE -,623,1986 |
skin rabbit | 483 mg/24 hour | mild | TXAPA9 19,276,1971 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | human lymphocyte | 150 mmol/L | MUREAV 320,125,1994 |
dominant lethal test |
oral rat | 500 mg/kg | ENMUDM 6,390,1984 |
sperm morphology |
oral mouse | 500 mg/kg | ENMUDM 6,390,1984 |
sperm morphology |
oral rat | 500 mg/kg | ENMUDM 6,390,1984 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mouse | lowest published toxic concentration: 1,000 ppm/6 hour (11 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 61,368,1981 |
inhalation mouse | lowest published toxic concentration: 500 ppm/7 hour (5 day male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TXAPA9 70,303,1983 |
inhalation mouse | lowest published toxic concentration: 50 ppm/6 hour (6-15 day pregnant) |
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Urogenital system | TXAPA9 75,409,1984 |
inhalation mouse | lowest published toxic concentration: 50 ppm/6 hour (6-15 day pregnant) |
Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system | EVHPAZ 57,7,1984 |
inhalation rat | lowest published toxic concentration: 68 mg/kg/4 hour (1-19 day pregnant) |
Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAVUAI 21,30,1989 |
inhalation rat | lowest published toxic concentration: 30 ppm/6 hour (65 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FAATDF 3,49,1983 |
inhalation rat | lowest published toxic concentration: 100 ppm/6 hour (6-17 day pregnant) |
Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | TXAPA9 69,43,1983 |
inhalation rat | lowest published toxic concentration: 100 ppm/6 hour (6-17 day pregnant) |
Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TXAPA9 69,43,1983 |
inhalation rat | lowest published toxic concentration: 30 ppm/6 hour (13 week male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAATDF 3,80,1983 |
inhalation rat | lowest published toxic concentration: 933 mg/m3 (6-17 day pregnant) |
Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | VCVGK* -,160,1994 |
inhalation rabbit | lowest published toxic concentration: 300 ppm/6 hour (65 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FAATDF 3,49,1983 |
inhalation rabbit | lowest published toxic concentration: 50 ppm/6 hour (6-18 day pregnant) |
Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Specific developmental abnormalities: Urogenital system | TXAPA9 75,409,1984 |
inhalation rabbit | lowest published toxic concentration: 50 ppm/6 hour (6-18 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Musculoskeletal system | EVHPAZ 57,7,1984 |
inhalation rabbit | lowest published toxic concentration: 10 ppm/6 hour (6-18 day pregnant) |
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 75,409,1984 |
intraperitoneal rat | lowest published toxic dose: 330 mg/kg (12 day pregnant) |
Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TJADAB 29(2),54A,1984 |
intraperitoneal rat | lowest published toxic dose: 190 mg/kg (14 day pregnant) |
Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Urogenital system | JJATDK 4,35,1984 |
intraperitoneal rat | lowest published toxic dose: 190 mg/kg (12 day pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | JJATDK 4,35,1984 |
intraperitoneal rat | lowest published toxic dose: 190 mg/kg (8 day pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JJATDK 4,35,1984 |
intravenous mouse | lowest published toxic dose: 250 mg/kg (8 day pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | TOXID9 12,101,1992 |
oral guinea pig | lowest published toxic dose: 6,250 mg/kg (25 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | EVHPAZ 57,75,1984 |
oral hamster | lowest published toxic dose: 1,562 mg/kg (25 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | EVHPAZ 57,75,1984 |
oral monkey | lowest published toxic dose: 930 mg/kg (20-45 day pregnant) |
Reproductive: Effects on fertility: Abortion Reproductive: Effects on embryo or fetus: Fetal death | TJADAB 35,66A,1987 |
oral monkey | lowest published toxic dose: 633 mg/kg (20-45 day pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TJADAB 35,66A,1987 |
oral mouse | lowest published toxic dose: 175 mg/kg (11 day pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TJADAB 31,48A,1985 |
oral mouse | lowest published toxic dose: 2 gm/kg (7-14 day pregnant) |
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system | TXCYAC 20,335,1981 |
oral mouse | lowest published toxic dose: 500 mg/kg (9 day pregnant) |
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 80,108,1985 |
oral mouse | lowest published toxic dose: 250 mg/kg (11 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 80,108,1985 |
oral mouse | lowest published toxic dose: 6,250 mg/kg (25 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | SAIGBL 21,29,1979 |
oral mouse | lowest published toxic dose: 11,200 mg/kg (7-14 day pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | EVHPAZ 57,141,1984 |
oral mouse | lowest published toxic dose: 1,000 mg/kg (6-17 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,160,1994 |
oral mouse | lowest published toxic dose: 2 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB89152565 |
oral mouse | lowest published toxic dose: 4.45 gm/kg (7 day prior to copulation/21 day pregnant) | Reproductive: Maternal effects: Postpartum | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 5.6 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 7.2 gm/kg (7 day male/7 day prior to copulation-1 day after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB88192240 |
oral mouse | lowest published toxic dose: 8.4 gm/kg (7 day male/7 day prior to copulation) | Reproductive: Effects on fertility: Other measures of fertility | NTIS** #PB88192240 |
oral mouse | lowest published toxic dose: 11.8 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) |
Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 14 gm/kg (14 day male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 14 gm/kg (14 day prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 17.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) |
Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB89152565 |
oral mouse | lowest published toxic dose: 35.28 gm/kg (15 week prior to copulation) |
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 43 gm/kg (15 week male/15 week prior to copulation-3 week after birth) |
Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB89152565 |
oral mouse | lowest published toxic dose: 50 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Urogenital system | NTIS** #PB89152565 |
oral mouse | lowest published toxic dose: 159 mg/kg (multigenerations) |
Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 159 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 170 mg/kg (multigenerations) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB89152565 |
oral mouse | lowest published toxic dose: 19 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) | Reproductive: Effects on fertility: Other measures of fertility | NTIS** #PB88211446 |
oral mouse | lowest published toxic dose: 200 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB88211446 |
oral mouse | lowest published toxic dose: 60 mg/kg (multigenerations) |
Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system | NTIS** #PB88211446 |
oral rat | lowest published toxic dose: 175 mg/kg (7-13 day pregnant) | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TJADAB 32,33,1985 |
oral rat | lowest published toxic dose: 175 mg/kg (7-13 day pregnant) |
Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Biochemical and metabolic | DCTODJ 9,1,1986 |
oral rat | lowest published toxic dose: 15,015 mg/kg (13 week male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | NTPTR* NIH-93-3349 |
oral rat | lowest published toxic dose: 100 mg/kg (1 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 69,385,1983 |
oral rat | lowest published toxic dose: 350 mg/kg (9-15 day pregnant) |
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TXAPA9 86,197,1986 |
oral rat | lowest published toxic dose: 250 mg/kg (13 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 145,415,1997 |
oral rat | lowest published toxic dose: 1,000 mg/kg (6-17 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,160,1994 |
oral rat | lowest published toxic dose: 350 mg/kg (9-15 day pregnant) |
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 82,197,1986 |
oral rat | lowest published toxic dose: 350 mg/kg (9-15 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TXAPA9 82,197,1986 |
oral rat | lowest published toxic dose: 5.5 gm/kg (21 week male) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB90252321/AS |
oral rat | lowest published toxic dose: 36.75 gm/kg (21 week male/21 week prior to copulation) | Reproductive: Effects on fertility: Other measures of fertility | NTIS** #PB90252321/AS |
oral rat | lowest published toxic dose: 30 mg/kg (multigenerations) |
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Sex ratio | NTIS** #PB90252321 |
oral rat | lowest published toxic dose: 37.5 mg/kg (multigenerations) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB90252321/AS |
oral rat | lowest published toxic dose: 1,050 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) |
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Sex ratio | NTIS** #PB90252321 |
oral rat | lowest published toxic dose: 3,570 mg/kg (17 week male) | Reproductive: Effects on newborn: Sex ratio | NTIS** #PB90252321 |
oral rat | lowest published toxic dose: 15 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB90252321 |
oral rat | lowest published toxic dose: 262 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB90252321 |
oral rabbit | lowest published toxic dose: 1,000 mg/kg (6-17 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,160,1994 |
subcutaneous mouse | lowest published toxic dose: 1,200 mg/kg (7-13 day pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TOLED5 50,263,1990 |
subcutaneous mouse | lowest published toxic dose: 3,200 mg/kg (7-14 day pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TOLED5 50,263,1990 |
subcutaneous mouse | lowest published toxic dose: 250 mg/kg (8 day pregnant) |
Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TJADAB 54,219,1996 |
subcutaneous rat | lowest published toxic dose: 600 mg/kg (6-20 day pregnant) |
Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | EVHPAZ 57,199,1984 |
subcutaneous rat | lowest published toxic dose: 440 mg/kg (7-17 day pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | TCMUD8 7,73,1987 |
skin guinea pig | lowest published toxic dose: 65 gm/kg (65 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FAATDF 6,339,1986 |
skin rat | lowest published toxic dose: 11,592 mg/kg (6-17 day pregnant) |
Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on embryo or fetus: Fetal death | JJATDK 6,165,1986 |
skin rat | lowest published toxic dose: 4,375 mg/kg (7 day male) |
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | TXAPA9 100,145,1989 |
skin rat | lowest published toxic dose: 2 gm/kg (10 day pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAATDF 15,448,1990 |
skin rat | lowest published toxic dose: 1 gm/kg (12 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Gastrointestinal system | FAATDF 15,448,1990 |
skin rat | lowest published toxic dose: 2.5 mg/kg (7-16 day pregnant) |
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,159,1994 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation human | lowest published toxic concentration: 25 ppm |
Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) | JIHTAB 20,134,1938 |
inhalation mouse | lethal concentration (50 percent kill): 1,480 ppm/7 hour |
Behavioral: Analgesia Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria | JIHTAB 25,157,1943 |
inhalation rat | lethal concentration (50 percent kill): 1,500 ppm/7 hour | N/R | NPIRI* 1,57,1974 |
inhalation rat | lowest published toxic concentration: 625 ppm/4 hour | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | ARTODN Suppl.7,167,1984 |
inhalation rat | lowest published toxic concentration: 1,000 ppm/4 hour |
Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight | ARTODN Suppl.7,167,1984 |
intraperitoneal mouse | lethal dose (50 percent kill): 2,147 mg/kg |
Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Blood: Changes in spleen Blood: Other changes | FEPRA7 6,342,1947 |
intraperitoneal rat | lethal dose (50 percent kill): 2,500 mg/kg | N/R | NPIRI* 1,57,1974 |
intraperitoneal rat | lowest published toxic dose: 50 mg/kg | Reproductive: Effects on fertility: Other measures of fertility | REPTED 14,45,2000 |
intraperitoneal rat | lowest published toxic dose: 150 mg/kg |
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,159,1984 |
intravenous rat | lethal dose (50 percent kill): 2,068 mg/kg | Blood: Other hemolysis with or without anemia | AMIHAB 14,114,1956 |
oral guinea pig | lethal dose (50 percent kill): 950 mg/kg |
Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 23,259,1941 |
oral guinea pig | lowest published toxic dose: 200 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct | EXMPA6 61,119,1994 |
oral guinea pig | lowest published toxic dose: 300 mg/kg | Blood: Other changes | EXMPA6 61,119,1994 |
oral human | lowest published lethal dose: 3,380 mg/kg |
Gastrointestinal: Gastritis Liver: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 28,267,1946 |
oral human | lowest published lethal dose: 143 mg/kg | N/R | VCVGK* -,159,1984 |
oral mouse | lethal dose (50 percent kill): 2,560 mg/kg |
Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Cardiac: Other changes | GTPZAB 32(3),48,1988 |
oral mouse | lethal dose (50 percent kill): 2,800 mg/kg |
Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,159,1984 |
oral rat | lethal dose (50 percent kill): 2,370 mg/kg |
Behavioral: Altered sleep time (including change in righting reflex) Lung, Thorax, or Respiration: Other changes | VHTODE 29,361,1987 |
oral rat | lowest published toxic dose: 250 mg/kg | Related to Chronic Data: Changes in prostate weight | REPTED 6,491,1992 |
oral rat | lowest published toxic dose: 200 mg/kg |
Blood: Normocytic anemia Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 61,119,1994 |
oral rat | lethal dose (50 percent kill): 2,460 mg/kg |
Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,159,1984 |
oral rat | lowest published toxic dose: 150 mg/kg |
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | JOAND3 5,369,1984 |
oral rat | lowest published toxic dose: 200 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TXAPA9 134,100,1995 |
oral rabbit | lethal dose (50 percent kill): 890 mg/kg |
Behavioral: General anesthetic Blood: Other hemolysis with or without anemia | AMIHAB 14,114,1956 |
oral rabbit | lethal dose (50 percent kill): 890 mg/kg |
Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,159,1984 |
skin rabbit | lethal dose (50 percent kill): 1,280 mg/kg | N/R | NPIRI* 1,57,1974 |
skin rabbit | lethal dose (50 percent kill): 2,000 mg/kg | Kidney, Ureter, and Bladder: Urine volume decreased or anuria | VCVGK* -,159,1984 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation dog | lowest published toxic concentration: 750 ppm/7 hour/12 week- intermittent |
Blood: Microcytosis with or without anemia Blood: Other changes | JIHTAB 25,409,1943 |
inhalation dog | lowest published toxic concentration: 2,500 mg/m3/7 hour/60 day- intermittent |
Blood: Changes in spleen Blood: Microcytosis with or without anemia | VCVGK* -,160,1994 |
inhalation mammal (species unspecified) | lowest published toxic concentration: 1,240 mg/m3/6 hour/5 day- intermittent |
Nutritional and Gross Metabolic: Weight loss or decreased weight gain Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Brain and Coverings: Other degenerative changes | VCVGK* -,159,1994 |
inhalation mouse | lowest published toxic concentration: 1,000 ppm/6 hour/11 day- intermittent |
Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight | TXAPA9 61,368,1981 |
inhalation mouse | lowest published toxic concentration: 3,680 mg/m3/6 hour/9 day- intermittent |
Spinal Cord: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,159,1994 |
inhalation mouse | lowest published toxic concentration: 3,680 mg/m3/6 hour/9 day- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,159,1994 |
inhalation rat | lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent |
Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | ENVRAL 22,423,1980 |
inhalation rat | lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent |
Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | FAATDF 3,49,1983 |
inhalation rat | lowest published toxic concentration: 970 mg/m3/7 hour/5 week- intermittent |
Blood: Changes in bone marrow not included in above Blood: Changes in spleen | JIHTAB 25,374,1943 |
inhalation rat | lowest published toxic concentration: 1,000 ppm/6 hour/11 day- intermittent |
Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in bone marrow not included in above Blood: Changes in leukocyte (WBC) count | TXAPA9 61,368,1981 |
inhalation rat | lowest published toxic concentration: 3,680 mg/m3/6 hour/9 day- intermittent |
Spinal Cord: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,159,1994 |
inhalation rat | lowest published toxic concentration: 3,680 mg/m3/6 hour/9 day- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,159,1994 |
inhalation rat | lowest published toxic concentration: 1,100 mg/m3/10 day- intermittent |
Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VCVGK* -,160,1994 |
inhalation rabbit | lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent |
Endocrine: Changes in thymus weight Blood: Changes in erythrocyte (RBC) count Related to Chronic Data: Changes in testicular weight | FAATDF 3,49,1983 |
intraperitoneal rat | lowest published toxic dose: 450 mg/kg/16 day- intermittent |
Blood: Changes in other cell count (unspecified) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TIHEEC 9,617,1993 |
oral guinea pig | lowest published toxic dose: 600 mg/kg/3 day- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 61,119,1994 |
oral mouse | lowest published toxic dose: 12,110 mg/kg/2 week- continuous |
Endocrine: Changes in thymus weight Related to Chronic Data: Changes in testicular weight | NTPTR* NIH-93-3349 |
oral mouse | lowest published toxic dose: 82 gm/kg/13 week- continuous |
Endocrine: Effect on menstrual cycle Endocrine: Other changes Blood: Changes in spleen | NTPTR* NIH-93-3349 |
oral mouse | lowest published toxic dose: 11,200 mg/kg/8 day- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | EVHPAZ 57,141,1984 |
oral mouse | lowest published toxic dose: 8,820 mg/kg/21 week- continuous | Kidney, Ureter, and Bladder: Changes in kidney weight | NTIS** #PB88211446 |
oral mouse | lowest published toxic dose: 29,400 mg/kg/21 week- continuous | Liver: Changes in liver weight | NTIS** #PB88211446 |
oral mouse | lowest published toxic dose: 80,850 mg/kg/21 week- continuous |
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | NTIS** #PB88211446 |
oral mouse | lowest published toxic dose: 8,820 mg/kg/21 week- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** #PB88211446 |
oral mouse | lowest published toxic dose: 126,000 mg/kg/15 week- continuous |
Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB89152565 |
oral mouse | lowest published toxic dose: 17,850 mg/kg/15 week- continuous |
Liver: Changes in liver weight Reproductive: Paternal effects: Testes, epididymis, sperm duct | NTIS** #PB89152565 |
oral mouse | lowest published toxic dose: 6,300 mg/kg/15 week- continuous | Liver: Changes in liver weight | NTIS** #PB88192240 |
oral mouse | lowest published toxic dose: 4,200 mg/kg/7 day- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB88192240 |
oral mouse | lowest published toxic dose: 4,200 mg/kg/7 day- continuous |
Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | NTIS** #PB88192240 |
oral mouse | lowest published toxic dose: 9,800 mg/kg/49 day- continuous |
Liver: Changes in liver weight Reproductive: Maternal effects: Ovaries, fallopian tubes | NTIS** #PB88192240 |
oral mouse | lowest published toxic dose: 21,665 mg/kg/28 day- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB86163136 |
oral mouse | lowest published toxic dose: 35,280 mg/kg/15 week- continuous | Reproductive: Maternal effects: Menstrual cycle changes or disorders | NTIS** #PB86163136 |
oral rat | lowest published toxic dose: 10,206 mg/kg/21 day- continuous |
Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | FAATDF 16,830,1991 |
oral rat | lowest published toxic dose: 500 mg/kg/10 day- intermittent |
Endocrine: Changes in thymus weight Immunological Including Allergic: Decreased immune response | TXAPA9 109,494,1991 |
oral rat | lowest published toxic dose: 29,484 mg/kg/13 week- continuous |
Endocrine: Changes in thymus weight Blood: Changes in platelet count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NIH-93-3349 |
oral rat | lowest published toxic dose: 900 mg/kg/3 day- intermittent | Reproductive: Maternal effects: Menstrual cycle changes or disorders | TXAPA9 142,328,1997 |
oral rat | lowest published toxic dose: 4,500 mg/kg/15 day- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight | TXAPA9 142,328,1997 |
oral rat | lowest published toxic dose: 1,050 mg/kg/2 week- continuous |
Reproductive: Maternal effects: Oogenesis Reproductive: Effects on fertility: Other measures of fertility | REPTED 14,45,2000 |
oral rat | lowest published toxic dose: 600 mg/kg/3 day- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 61,119,1994 |
oral rat | lowest published toxic dose: 500 mg/kg/10 day- intermittent |
Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VCVGK* -,160,1994 |
oral rat | lowest published toxic dose: 700 mg/kg/7 day- intermittent |
Liver: Changes in liver weight Nutritional and Gross Metabolic: Changes in: Ca Related to Chronic Data: Changes in uterine weight | TXAPA9 82,197,1986 |
oral rat | lowest published toxic dose: 1,200 mg/kg/8 day- intermittent | Related to Chronic Data: Changes in testicular weight | JOAND3 5,369,1984 |
oral rat | lowest published toxic dose: 1,400 mg/kg/1 week- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 25,259,2000 |
oral rat | lowest published toxic dose: 2,800 mg/kg/2 week- intermittent |
Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | JTSCDR 25,259,2000 |
oral rat | lowest published toxic dose: 200 mg/kg/2 day- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 40,169,1984 |
skin guinea pig | lowest published toxic dose: 65 gm/kg/13 week- intermittent |
Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | FAATDF 6,339,1986 |
skin rat | lowest published toxic dose: 20 gm/kg/4 week- intermittent |
Blood: Changes in other cell count (unspecified) Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight | TXCYAC 57,209,1989 |
skin rat | lowest published toxic dose: 3,200 mg/kg/4 day- intermittent |
Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response | TXCYAC 98,215,1995 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 5 ppm (skin) | DTLVS* TLV/BEI,2003 |
TOXICOLOGY REVIEW |
| FAATDF 13,747,1989 |
TOXICOLOGY REVIEW |
| CRTXB2 30,307,2000 |
TOXICOLOGY REVIEW |
| JTSCDR 25,1,2000 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 | PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF | PESTICIDES: Cancelled | RBREV* -,241,1998 |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 25 ppm (80 mg/m3) (skin) | DTLVS* 3,158,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 25 ppm (80 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 25 ppm (80 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 25 ppm (80 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 25 ppm (80 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 5 ppm (16 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 5 ppm (15 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 5 ppm (16 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 5 ppm (16 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 25 ppm (80 mg/m3), short term exposure limit 40 ppm (120 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 5 ppm (16 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 5 ppm (15 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - HUNGARY | time-weighted average 15 mg/m3, short term exposure limit 30 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 1 mg/m3, Skin, 2003 | |
Occupational Exposure Limit - NORWAY | time-weighted average 5 ppm (16 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 25 ppm (80 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 60 mg/m3, JAN1999 | |
Occupational Exposure Limit - RUSSIA | time-weighted average 5 ppm, JAN1993 | |
Occupational Exposure Limit - SWEDEN | NGV 5 ppm (16 mg/m3), KTV 10 ppm (30 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 5 ppm (15 mg/m3), KZG- week 10 ppm (30 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - TURKEY | time-weighted average 25 ppm (80 mg/m3), JAN1993 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 5 ppm (16 mg/m3), Skin, SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 5 ppm (skin) | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEGLYCOL MONOMETHYL ETHER-air | 10 hour time-weighted average 0.1 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 46240; Number of Industries 128; Total Number of Facilities 11,165; Number of Occupations 102; Total Number of Employees Exposed 103,424 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 46240; Number of Industries 89; Total Number of Facilities 8,042; Number of Occupations 86; Total Number of Employees Exposed 168,180; Total Number of Female Employees Exposed 53,403 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as jet fuel additive, solvent for protective coating and in chemical synthesis | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9101 | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH CURRENT INTELLIGENCE BULLETIN, #39 | |
NIOSH Analytical Method, 1994: Alcohols IV, 1403 | |
NTP Toxicity studies, RPT# TOX-26, October 2000 | |
OSHA ANALYTICAL METHOD #53 | |
OSHA ANALYTICAL METHOD #79 |
REFERENCES: | |
CODEN |
REFERENCE |
85JCAE | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 |
AMIHAB | AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. |
ARTODN | Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
CRTXB2 | CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- |
DCTODJ | Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
ENMUDM | Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. |
ENVRAL | Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- |
EVHPAZ | EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- |
EXMPA6 | Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962- |
FAATDF | Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 |
FAVUAI | Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966- |
FEPRA7 | Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
JIHTAB | Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. |
JJATDK | JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- |
JOAND3 | Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- |
JPPMAB | Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- |
JTSCDR | Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NPIRI* | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
NTPTR* | National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- |
RBREV* | Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 |
REPTED | Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- |
SAIGBL | Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- |
TCMUD8 | Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- |
TIHEEC | Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985- |
TJADAB | Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
TOXID9 | Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |
TXCYAC | Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |
VHTODE | Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- |