The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - isopropoxy -

RTECS #: KL5075000

CAS #: 109-59-1

UPDATE: November 2004 MW: 104.17 MF: C5H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Isopropoxyethanol
  2. 2 - Isopropoxyethanol (ACGIH)
  3. Dowanol eipat
  4. Ethylene glycol isopropyl ether
  5. Ethylene glycol, monoisopropyl ether
  6. Isopropyl cellosolve
  1. Isopropyl glycol
  2. Isopropyl oxitol
  3. Isopropylethylene glycol ether
  4. Monoisopropyl ether of ethylene glycol
  5. beta - Hydroxyethyl isopropyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,627,1986
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,627,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 1,930 ppm/7 hour Behavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria 		JIHTAB 25,157,1943
inhalation
rat 		lethal concentration (50 percent kill): 3,100 mg/m3/4 hour N/R 85GMAT -,67,1982
intraperitoneal
mammal (species unspecified) 		lowest published toxic dose: 100 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVGK* -,165,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,860 mg/kg N/R 85GMAT -,67,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other hemolysis with or without anemia 		VCVGK* -,165,1984
intraperitoneal
rat 		lethal dose (50 percent kill): 800 mg/kg N/R 85GMAT -,67,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other hemolysis with or without anemia 		VCVGK* -,165,1984
intraperitoneal
rabbit 		lethal dose (50 percent kill): 800 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other hemolysis with or without anemia 		VCVGK* -,165,1984
oral
mouse 		lethal dose (50 percent kill): 4,900 mg/kg N/R 85GMAT -,67,1982
oral
rat 		lethal dose (50 percent kill): 5,660 µL/kg N/R AIHAAP 30,470,1969
skin
rabbit 		lethal dose (50 percent kill): 1,600 µL/kg N/R AIHAAP 30,470,1969
unreported route
mouse 		lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes 		GISAAA 41(11),7,1976
unreported route
rat 		lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes 		GISAAA 41(11),7,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 200 ppm/6 hour/26 week- intermittent Cardiac: Changes in heart weight

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0556079
inhalation
guinea pig 		lowest published toxic concentration: 200 ppm/6 hour/26 week- intermittent Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0556079
inhalation
rat 		lowest published toxic concentration: 1,650 mg/m3/7 hour/5 week- intermittent Blood: Changes in spleen JIHTAB 25,374,1943
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/24 hour/13 week- continuous Endocrine: Hypoglycemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 41(11),7,1976
inhalation
rat 		lowest published toxic concentration: 142 ppm/6 hour/4 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in spleen

Blood: Changes in erythrocyte (RBC) count 		INHTE5 4,43,1992
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour/26 week- intermittent Endocrine: Changes in spleen weight

Blood: Other changes

Blood: Changes in erythrocyte (RBC) count 		NTIS** OTS0556079
inhalation
rat 		lowest published toxic concentration: 1,000 mg/m3/4 hour/30 day- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Changes in cell count (unspecified) 		VCVGK* -,165,1994
inhalation
rat 		lowest published toxic concentration: 30 mg/m3/90 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,165,1994
inhalation
rabbit 		lowest published toxic concentration: 200 ppm/6 hour/26 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Musculoskeletal: Other changes 		NTIS** OTS0556079


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (105 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (106 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (105 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (105 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (80 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 44 mg/m3, 2003
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 44 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7487;
Number of Industries 1;
Total Number of Facilities 32;
Number of Occupations 5;
Total Number of Employees Exposed 1,357;
Total Number of Female Employees Exposed 63


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Primary Irritant

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