The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - ethoxy - , acetate

RTECS #: KK8225000

CAS #: 111-15-9

UPDATE: November 2004 MW: 132.18 MF: C6H12O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Aethoxy - aethylacetat (German)
  2. 2 - Ethoxy - ethylacetaat (Dutch)
  3. 2 - Ethoxyethanol acetate
  4. 2 - Ethoxyethanol, ester with acetic acid
  5. 2 - Ethoxyethyl acetate
  6. 2 - Ethoxyethyl acetate (ACGIH:OSHA)
  7. 2 - Ethoxyethylacetate
  8. 2 - Ethoxyethyle, acetate de (French)
  9. 2 - Ethoxyethylester kyseliny octove (Czech)
  10. 2 - Etossietil - acetato (Italian)
  11. Acetate d'ethylglycol (French)
  12. Acetate de cellosolve (French)
  13. Acetate de l'ether monoethylique de l'ethylene - glycol (French)
  14. Acetato di cellosolve (Italian)
  15. Acetic acid, 2 - ethoxyethyl ester
  16. Aethylenglykolaetheracetat (German)
  17. CSAC
  18. Cellosolve acetate
  1. Cellosolve acetate (OSHA)
  2. Celosolvacetat (Czech)
  3. EGEEA
  4. Ektasolve EE acetate solvent
  5. Ethoxy acetate
  6. Ethoxyethyl acetate
  7. Ethyl cellosolve acetaat (Dutch)
  8. Ethylene glycol ethyl ether acetate
  9. Ethylene glycol monoethyl ether acetate
  10. Ethylglycol acetate
  11. Ethylglykolacetat (German)
  12. Glycol ether EE acetate
  13. Glycol monoethyl ether acetate
  14. Octan etoksyetylu (Polish)
  15. Oxytol acetate
  16. Poly - Solv EE acetate
  17. beta - Ethoxyethyl acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		40 mg moderate UCDS** 1/13/1967
skin
rabbit 		490 mg open irritation test mild UCDS** 1/13/1967


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 600 ppm/7 hour (7-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death EPASR* 8EHQ-0682-0450
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Respiratory system 		FAATDF 10,20,1988
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system 		UCRR** 09OCT1984
inhalation
rat 		lowest published toxic concentration: 50 mg/kg/4 hour (1-19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		FAVUAI 21,30,1989
inhalation
rat 		lowest published toxic concentration: 50 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system UCRR** 09OCT1984
inhalation
rabbit 		lowest published toxic concentration: 200 ppm/6 hour (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system 		UCRR** 09OCT1984
inhalation
rabbit 		lowest published toxic concentration: 200 ppm/6 hour (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		UCRR** 09OCT1984
inhalation
rabbit 		lowest published toxic concentration: 100 ppm/6 hour (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system UCRR** 09OCT1984
inhalation
rabbit 		lowest published toxic concentration: 100 ppm/6 hour (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		EVHPAZ 57,33,1984
inhalation
rabbit 		lowest published toxic concentration: 450 ppm/6 hour (6-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** OTS0544004
oral
mouse 		lowest published toxic dose: 25 gm/kg (25 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct SAIGBL 21,29,1979
oral
mouse 		lowest published toxic dose: 100 gm/kg (25 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands SAIGBL 21,29,1979
oral
mouse 		lowest published toxic dose: 0.93 gm/kg (multigenerations) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Specific developmental abnormalities: Hepatobiliary system 		NTIS** #PB86139565
oral
mouse 		lowest published toxic dose: 1.86 gm/kg (multigenerations) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) NTIS** #PB86139565
oral
mouse 		lowest published toxic dose: 1.86 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS** #PB86139565
oral
mouse 		lowest published toxic dose: 441 gm/kg (21 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NTIS** #PB86139565
oral
mouse 		lowest published toxic dose: 65.1 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB86139565
skin
rat 		lowest published toxic dose: 70 gm/kg (7-16 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		EVHPAZ 57,69,1984
skin
rat 		lowest published toxic dose: 70 gm/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		EVHPAZ 57,69,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 12,100 mg/m3/8 hour N/R AIHAAP 20,364,1959
inhalation
rat 		lethal concentration (50 percent kill): >1,500 ppm/8 hour N/R IJOTO* 21,9,2002
inhalation
rabbit 		lethal concentration (50 percent kill): >2,000 ppm/4 hour Kidney, Ureter, and Bladder: Hematuria TXAPA9 51,117,1979
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,420 mg/kg N/R SCCUR* -,2,1961
oral
guinea pig 		lethal dose (50 percent kill): 1,910 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
oral
guinea pig 		lethal dose (50 percent kill): 1,910 mg/kg Behavioral: General anesthetic IJOTO* 21,9,2002
oral
rat 		lethal dose (50 percent kill): 2,700 mg/kg N/R GISAAA 53(10),78,1988
oral
rat 		lethal dose (50 percent kill): 2,900 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Hematuria 		IJOTO* 21,9,2002
oral
rabbit 		lethal dose (50 percent kill): 1,950 mg/kg N/R EPASR* 8EHQ-0682-0450
subcutaneous
mouse 		lowest published lethal dose: 5 gm/kg N/R JPETAB 42,355,1931
skin
guinea pig 		lethal dose (50 percent kill): >19,460 mg/kg N/R EPASR* 8EHQ-0682-0450
skin
rabbit 		lethal dose (50 percent kill): 10,500 µL/kg N/R UCDS** 1/13/1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 84 gm/kg/4 week- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB86139565
oral
mouse 		lowest published toxic dose: 441 gm/kg/21 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB86139565
oral
rat 		lowest published toxic dose: 7,560 mg/kg/2 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		ARTODN 73,229,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
IJOTO* 21,9,2002
TOXICOLOGY REVIEW
CRTXB2 30,307,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (540 mg/m3) (skin) DTLVS* 3,101,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (540 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (540 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (540 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (540 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (27 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 20 ppm (110 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (27 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (27.0 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (270 mg/m3), short term exposure limit 100 ppm (540 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (27 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 20 ppm (110 mg/m3), Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 25 mg/m3, short term exposure limit 50 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 27 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (27 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (540 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 5 ppm, JAN1993
Occupational Exposure Limit - SWEDEN NGV 5 ppm (30 mg/m3), KTV 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (27 mg/m3), KZG- week 10 ppm (54 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (540 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (55 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGEEA-air 10 hour time-weighted average 0.5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4063;
Number of Industries 228;
Total Number of Facilities 38,895;
Number of Occupations 127;
Total Number of Employees Exposed 321,063
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4063;
Number of Industries 149;
Total Number of Facilities 16,901;
Number of Occupations 103;
Total Number of Employees Exposed 265,104;
Total Number of Female Employees Exposed 51,020


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0693-9068
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IJOTO* International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
UCRR** Union Carbide Research Report. (Union Carbide Corp., Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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