The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - dimethylamino -

RTECS #: KK6125000

CAS #: 108-01-0

UPDATE: November 2004 MW: 89.16 MF: C4H11NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Amietol M 21
  2. Dimethylaethanolamin (German)
  3. Dimethylaminoaethanol (German)
  4. Dimethylaminoethanol
  5. N - Dimethylaminoethanol
  6. N,N - Dimethylaminoethanol
  7. beta - Dimethylaminoethanol
  8. 2 - Dimethylaminoethanol
  9. 2 - (Dimethylamino) ethanol
  10. beta - Dimethylaminoethyl alcohol
  11. N,N - Dimethylethanolamine
  12. N,N - Dimethyl - N - (2 - hydroxyethyl) amine
  1. N,N - Dimethyl - 2 - hydroxyethylamine
  2. DMAE
  3. 2 - Dwumetyloaminoetanolu (Polish)
  4. Bimanol
  5. Deanol
  6. beta - Hydroxyethyldimethylamine
  7. Kalpur P
  8. Liparon
  9. Norcholine
  10. Propamine A
  11. Texacat DME


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 µL severe VHTODE 38,422,1996
skin
rabbit 		445 mg open irritation test mild UCDS** 12/15/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 3,250 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold 		GTPZAB 14(11),52,1970
inhalation
rat 		lethal concentration (50 percent kill): 1,641 ppm/4 hour Eye: Lacrimation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		FAATDF 9,512,1987
intraperitoneal
guinea pig 		lowest published lethal dose: 450 mg/kg N/R PSEBAA 85,642,1954
intraperitoneal
mouse 		lethal dose (50 percent kill): 234 mg/kg Behavioral: Ataxia JPETAB 94,249,1948
intraperitoneal
rat 		lethal dose (50 percent kill): 1,080 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 12,486,1968
oral
rat 		lethal dose (50 percent kill): 2 gm/kg N/R ZHYGAM 20,393,1974
subcutaneous
mouse 		lethal dose (50 percent kill): 961 mg/kg Behavioral: Tremor

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes 		AEPPAE 225,428,1955
skin
rabbit 		lethal dose (50 percent kill): 1,370 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 670 mg/m3/4 hour/22 week- intermittent Endocrine: Changes in adrenal weight

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 14(11),52,1970
inhalation
rat 		lowest published toxic concentration: 288 ppm/6 hour/2 week- intermittent Eye: Corneal damage

Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FAATDF 9,512,1987
inhalation
rat 		lowest published toxic concentration: 76 ppm/6 hour/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 9,512,1987
skin
rabbit 		lowest published toxic dose: 18 mL/kg/11 day- intermittent Skin: After systemic exposure: Dermatitis, other JTOTDO 14,219,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (7.4 mg/m3), short term exposure limit 6 ppm (22 mg/m3), SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 7.4 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83678;
Number of Industries 9;
Total Number of Facilities 249;
Number of Occupations 23;
Total Number of Employees Exposed 6,372
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83678;
Number of Industries 44;
Total Number of Facilities 1,838;
Number of Occupations 36;
Total Number of Employees Exposed 33,474;
Total Number of Female Employees Exposed 5,559


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as corrosion inhibitor, pharmaceutical intermediate and emulsifier
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955-

Used as corrosion inhibitor, pharmaceutical intermediate and emulsifier

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Primary Irritant

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