The Registry of Toxic Effects of Chemical Substances
Ethanol, 2 - dimethylamino - |
| UPDATE: November 2004 | MW: 89.16 | MF: C4H11NO |
SYNONYMS: | |
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
|
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
|
eye rabbit | 5 無 | severe | VHTODE 38,422,1996 |
|
skin rabbit | 445 mg open irritation test | mild | UCDS** 12/15/1971 |
MUTATION DATA AND REFERENCES: | |||
| SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
| N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
|
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
|
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
|
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
|
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
|
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
|
inhalation mouse | lethal concentration (50 percent kill): 3,250 mg/m3 |
Brain and Coverings: Recordings from specific areas of CNS Eye: Conjunctiva irritation Behavioral: Convulsions or effect on seizure threshold | GTPZAB 14(11),52,1970 |
|
inhalation rat | lethal concentration (50 percent kill): 1,641 ppm/4 hour |
Eye: Lacrimation Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | FAATDF 9,512,1987 |
|
intraperitoneal guinea pig | lowest published lethal dose: 450 mg/kg | N/R | PSEBAA 85,642,1954 |
|
intraperitoneal mouse | lethal dose (50 percent kill): 234 mg/kg | Behavioral: Ataxia | JPETAB 94,249,1948 |
|
intraperitoneal rat | lethal dose (50 percent kill): 1,080 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 12,486,1968 |
|
oral rat | lethal dose (50 percent kill): 2 gm/kg | N/R | ZHYGAM 20,393,1974 |
|
subcutaneous mouse | lethal dose (50 percent kill): 961 mg/kg |
Behavioral: Tremor Behavioral: Coma Lung, Thorax, or Respiration: Other changes | AEPPAE 225,428,1955 |
|
skin rabbit | lethal dose (50 percent kill): 1,370 無/kg | N/R | AMIHBC 4,119,1951 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
|
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
|
inhalation rat | lowest published toxic concentration: 670 mg/m3/4 hour/22 week- intermittent |
Endocrine: Changes in adrenal weight Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | GTPZAB 14(11),52,1970 |
|
inhalation rat | lowest published toxic concentration: 288 ppm/6 hour/2 week- intermittent |
Eye: Corneal damage Behavioral: Food intake (animal) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FAATDF 9,512,1987 |
|
inhalation rat | lowest published toxic concentration: 76 ppm/6 hour/13 week- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 9,512,1987 |
|
skin rabbit | lowest published toxic dose: 18 mL/kg/11 day- intermittent | Skin: After systemic exposure: Dermatitis, other | JTOTDO 14,219,1995 |
REVIEWS: | ||
| ORGANIZATION | STANDARD |
REFERENCE |
| N/R | N/R | N/R |
STANDARDS AND REGULATIONS: | ||
| ORGANIZATION | STANDARD |
REFERENCE |
| Occupational Exposure Limit - RUSSIA | short term exposure limit 5 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 2 ppm (7.4 mg/m3), short term exposure limit 6 ppm (22 mg/m3), SEP2000 | |
| Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 7.4 mg/m3, 2003 | |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
| ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
| National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 83678; Number of Industries 9; Total Number of Facilities 249; Number of Occupations 23; Total Number of Employees Exposed 6,372 | |
| National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 83678 ;Number of Industries 44; Total Number of Facilities 1,838; Number of Occupations 36; Total Number of Employees Exposed 33,474; Total Number of Female Employees Exposed 5,559 |
|
STATUS IN FEDERAL AGENCIES: | |
| ORGANIZATION |
REFERENCE |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| Used as corrosion inhibitor, pharmaceutical intermediate and emulsifier | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
REFERENCES: | |
| CODEN |
REFERENCE |
| AEPPAE | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. |
| AMIHBC | AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. |
| FAATDF | Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 |
| GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
| JPETAB | Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- |
| JTOTDO | Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- |
| PSEBAA | Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- |
| TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |
| UCDS** | Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) |
| VHTODE | Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- |
| ZHYGAM | Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- |