The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - (diethylamino) -

RTECS #: KK5075000

CAS #: 100-37-8

UPDATE: November 2004 MW: 117.22 MF: C6H15NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - (Diethylamino) ethanol
  2. 2 - Diethylaminoethanol
  3. 2 - Diethylaminoethanol (ACGIH:OSHA)
  4. 2 - Hydroxytriethylamine
  5. 2 - N - Diethylaminoethanol
  6. DEAE
  7. Diaethylaminoaethanol (German)
  1. Diethylethanolamine
  2. N,N - Diethyl - N - (beta - hydroxyethyl) amine
  3. N,N - Diethylethanolamine
  4. N - Diethylaminoethanol
  5. beta - Diethylaminoethanol
  6. beta - Diethylaminoethyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg severe UCDS** 6/11/1963
skin
rabbit 		10 mg/24 hour open irritation test severe JIHTAB 26,269,1944
skin
rabbit 		500 mg open irritation test mild UCDS** 6/11/1963


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 200 ppm Gastrointestinal: Nausea or vomiting 34ZIAG -,216,1969
inhalation
mouse 		lethal concentration (50 percent kill): 5,000 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold 		GTPZAB 14(11),52,1970
inhalation
rat 		lowest published lethal concentration: 4,500 mg/m3/4 hour Brain and Coverings: Recordings from specific areas of CNS

Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold 		GTPZAB 14(11),52,1970
intramuscular
mouse 		lethal dose (50 percent kill): 416 mg/kg N/R ARZNAD 9,31,1959
intraperitoneal
mouse 		lethal dose (50 percent kill): 192 mg/kg Behavioral: Ataxia JPETAB 94,249,1948
intraperitoneal
rat 		lethal dose (50 percent kill): 1,220 mg/kg N/R TXAPA9 12,486,1968
intravenous
mouse 		lethal dose (50 percent kill): 188 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		ARZNAD 9,31,1959
oral
rat 		lethal dose (50 percent kill): 1,300 mg/kg N/R JIHTAB 26,269,1944
subcutaneous
mouse 		lethal dose (50 percent kill): 650 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		ARZNAD 9,31,1959
skin
guinea pig 		lethal dose (50 percent kill): 1 mL/kg N/R JIHTAB 26,269,1944
skin
rabbit 		lethal dose (50 percent kill): 1,260 µL/kg N/R UCDS** 6/11/1963
unreported route
mammal (species unspecified) 		lowest published lethal dose: 1,300 mg/kg N/R 34ZIAG -,216,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/5 day- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 26,479,1965
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour/26 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 26,479,1965
inhalation
rat 		lowest published toxic concentration: 76 ppm/6 hour/14 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 18,418,1992
inhalation
rat 		lowest published toxic concentration: 301 ppm/6 hour/2 week- intermittent Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FAATDF 18,418,1992
oral
dog 		lowest published toxic dose: 21,559 mg/kg/1 year- continuous Brain and Coverings: Other degenerative changes

Behavioral: Ataxia

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		NTIS** OTS0530455-1
oral
dog 		lowest published toxic dose: 4,875 mg/kg/39 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0536945


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (50 mg/m3) (skin) DTLVS* 3,85,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (50 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (50 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (50 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (50 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (50 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (48 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 9.6 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (50 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 50 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (49 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-DIETHYLAMINOETHANOL-air 10 hour time-weighted average 10 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24930;
Number of Industries 71;
Total Number of Facilities 7,801;
Number of Occupations 39;
Total Number of Employees Exposed 23,770
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24930;
Number of Industries 115;
Total Number of Facilities 11,825;
Number of Occupations 68;
Total Number of Employees Exposed 106,878;
Total Number of Female Employees Exposed 20,564


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an anticorrosive additive
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as an anticorrosive additive

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Human Data
   Primary Irritant

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