The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - (dibutylamino) -

RTECS #: KK3850000

CAS #: 102-81-8

UPDATE: November 2004 MW: 173.34 MF: C10H23NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Dibutylaminoethanol
  2. 2 - Di - n - butylaminoethanol
  3. 2 - N - Dibutylaminoethanol
  4. 2 - N - Dibutylaminoethanol (ACGIH)
  5. beta - n - Dibutylaminoethyl alcohol
  1. N,N - Dibutylethanolamine
  2. N,N - Dibutyl - N - (2 - hydroxyethyl) amine
  3. DBAE
  4. BU2AE


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test severe UCDS** 11/29/1963
skin
rabbit 		5 mg/24 hour severe 85JCAE -,695,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 120 mg/kg Cardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 8,344,1966
intraperitoneal
mouse 		lethal dose (50 percent kill): 52 mg/kg N/R RCRVAB 38,975,1969
intraperitoneal
rat 		lethal dose (50 percent kill): 144 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 12,486,1968
oral
rat 		lethal dose (50 percent kill): 1,070 mg/kg N/R AMIHBC 10,61,1954
skin
rabbit 		lethal dose (50 percent kill): 1,680 無/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 70 ppm/6 hour/5 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AIHAAP 30,46,1969
oral
rat 		lowest published toxic dose: 7 gm/kg/5 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight AIHAAP 30,46,1969


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (14 mg/m3) (skin) DTLVS* 3,74,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (14 mg/m3), Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (14 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm (14 mg/m3), short term exposure limit 4 ppm (28 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (14 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (14 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (14 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3.5 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-N-DIBUTYLAMINOETHANOL-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in industry as emulsifying, curing and flotation agent
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RCRVAB Russian Chemical Reviws (English Translation). Translation of USKHAB. (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.29- 1960-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in industry as emulsifying, curing and flotation agent

RTECS Compound Description:
   Primary Irritant

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