The Registry of Toxic Effects of Chemical Substances
Ethanol, 2 - (2 - butoxyethoxy) - |
UPDATE: November 2004 | MW: 162.26 | MF: C8H18O3 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
20 mg
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severe
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AJOPAA 29,1363,1946
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eye | rabbit
20 mg/24 hour
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moderate
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85JCAE -,635,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | mouse
lethal dose (50 percent kill): 850 mg/kg
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Lung, Thorax, or Respiration: Other changes | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen
FEPRA7 6,342,1947
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oral | guinea pig
lethal dose (50 percent kill): 2 gm/kg
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Behavioral: General anesthetic | Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
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oral | guinea pig
lethal dose (50 percent kill): 2,000 mg/kg
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Behavioral: Tetany | Lung, Thorax, or Respiration: Dyspnea Liver: Other changes
VCVGK* -,174,1984
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oral | human
lowest published lethal dose: 0.5 ml/kg
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N/R
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VCVGK* -,174,1984
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oral | mouse
lethal dose (50 percent kill): 2,400 mg/kg
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N/R
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JACTDZ 12,139,1993
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oral | mouse
lethal dose (50 percent kill): 6,050 mg/kg
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Behavioral: Tetany | Lung, Thorax, or Respiration: Dyspnea Liver: Other changes
VCVGK* -,174,1984
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oral | rat
lethal dose (50 percent kill): 5,660 mg/kg
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N/R
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DOWCC* MSD-41
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oral | rat
lethal dose (50 percent kill): 4,500 mg/kg
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Behavioral: Tetany | Lung, Thorax, or Respiration: Dyspnea Liver: Other changes
VCVGK* -,174,1984
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oral | rabbit
lethal dose (50 percent kill): 2,200 mg/kg
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N/R
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38MKAJ 2C,3964,1982
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skin | rabbit
lethal dose (50 percent kill): 2,700 mg/kg
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N/R
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JACTDZ 12,139,1993
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unreported route | mouse
lethal dose (50 percent kill): 6,050 mg/kg
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N/R
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GISAAA 46(2),14,1981
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unreported route | rat
lethal dose (50 percent kill): 4,500 mg/kg
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N/R
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GISAAA 46(2),14,1981
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 5 mg/m3/24 hour/17 week- continuous
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Brain and Coverings: Recordings from specific areas of CNS | Blood: Other changes
GISAAA 46(2),14,1981
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inhalation | rat
lowest published toxic concentration: 5 mg/m3/122 day- continuous
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Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
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VCVGK* -,175,1994
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oral | rat
lowest published toxic dose: 83 gm/kg/13 week- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 6,164,1986
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oral | rat
lowest published toxic dose: 109 gm/kg/6 week- intermittent
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Behavioral: Food intake (animal) | Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570960
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oral | rat
lowest published toxic dose: 102,375 mg/kg/13 week- intermittent
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Behavioral: Food intake (animal) | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,174,1994
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 50 mg/m3, Skin, 2003
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 80343; | Number of Industries 151; Total Number of Facilities 19,782; Number of Occupations 114; Total Number of Employees Exposed 246,257
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 80343; |
Number of Industries 266; Total Number of Facilities 42,981; Number of Occupations 158; Total Number of Employees Exposed 641,115; Total Number of Female Employees Exposed 173,797 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as a coalescing agent, solvent, dispersant and diluent
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EPA TSCA Section 8(d) unpublished health/safety studies
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
38MKAJ
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"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton,
eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd
rev. ed. in 1985.
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85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AJOPAA
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American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415,
Chicago, IL 60611) Series 3: V.1- 1918-
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DOWCC*
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Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology
Research Lab., Midland, MI 48640)
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FEPRA7
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Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda,
MD) V.1-46, 1942-87.
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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JACTDZ
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Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New
York, NY 10128) V.1-12, 1982-1993. Discontinued.
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JIHTAB
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Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For
publisher information, see AEHLAU.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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TOXID9
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Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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VCVGK*
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"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
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