The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - amino -

RTECS #: KJ5775000

CAS #: 141-43-5

UPDATE: November 2004 MW: 61.10 MF: C2H7NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Aethanolamin (German)
  2. 2 - Aminoaethanol (German)
  3. 2 - Aminoetanolo (Italian)
  4. 2 - Aminoethanol (OSHA)
  5. beta - Aminoethyl alcohol
  6. Colamine
  7. Etanolamina (Italian)
  8. Ethanolamine
  9. beta - Ethanolamine
  10. Ethanolamine (ACGIH:OSHA)
  1. Glycinol
  2. beta - Hydroxyethylamine
  3. 2 - Hydroxyethylamine
  4. Kolamin (Czech)
  5. Monoaethanolamin (German)
  6. Monoethanolamine
  7. Ethylolamine
  8. Olamine
  9. Thiofaco M - 50
  10. USAF EK - 1597


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg severe AJOPAA 29,1363,1946
skin
rabbit 		505 mg open irritation test moderate UCDS** 1/13/1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 µmol/L BZARAZ 39,422,1986
sister chromatid exchange human lymphocyte 1 mmol/L CYGEDX 21(6),29,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TCMUD8 6,403,1986
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TCMUD8 6,403,1986
oral
rat 		lowest published toxic dose: 4,500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female FAATDF 40,158,1997
skin
rat 		lowest published toxic dose: 2,250 mg/kg (6-15 day pregnant) Reproductive: Other effects on female FAATDF 31,117,1996


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration : >2,420 mg/m3/2 hour N/R GTPZAB 23(9),55,1979
inhalation
mouse 		lethal concentration : >2,420 mg/m3/2 hour N/R GTPZAB 23(9),55,1979
intramuscular
rat 		lethal dose (50 percent kill): 1,750 mg/kg N/R GTPZAB 23(9),55,1979
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 67 mg/kg N/R EVSSAV 2,289,1968
intravenous
rat 		lethal dose (50 percent kill): 225 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		KBMEAL (4),44,1968
oral
guinea pig 		lethal dose (50 percent kill): 620 mg/kg N/R EVSSAV 2,289,1968
oral
mammal (species unspecified) 		lowest published lethal dose: 1,400 mg/kg N/R NTIS** OTS0520710
oral
mouse 		lethal dose (50 percent kill): 700 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		TPKVAL 4,81,1962
oral
rat 		lethal dose (50 percent kill): 1,720 mg/kg N/R TXAPA9 42,417,1977
oral
rabbit 		lethal dose (50 percent kill): 1 gm/kg N/R GTPZAB 23(9),55,1979
subcutaneous
rat 		lethal dose (50 percent kill): 1,500 mg/kg N/R GTPZAB 23(9),55,1979
skin
rabbit 		lethal dose (50 percent kill): 1 mL/kg N/R UCDS** 1/13/1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 102 ppm/24 hour/30 day- continuous Behavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, irritative

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 21,374,1960
inhalation
guinea pig 		lowest published toxic concentration: 75 ppm/24 hour/24 day- continuous Behavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, irritative

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 21,374,1960
inhalation
rat 		lowest published toxic concentration: 66 ppm/24 hour/30 day- continuous Behavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, irritative

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 21,374,1960
inhalation
rat 		lowest published toxic concentration: 400 mg/m3/5 hour/26 week- intermittent Lung, Thorax, or Respiration: Respiratory depression

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Proteinuria 		TPKVAL 4,81,1962
inhalation
rat 		lowest published toxic concentration: 300 mg/m3/5 hour/26 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 23(9),55,1979
oral
rat 		lowest published toxic dose: 115 gm/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0516797
oral
rat 		lowest published toxic dose: 105 mg/kg/30 week- intermittent Liver: Liver function tests impaired

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 29(2),9,1964


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 6 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,308,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 3 ppm (6 mg/m3) DTLVS* 3,100,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 3 ppm (6 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 3 ppm (6 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 3 ppm (6 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 3 ppm (6 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 3 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 ppm (8 mg/m3), short term exposure limit 6 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 3 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 3 ppm (7.5 mg/m3), short term exposure limit 6 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 3 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 3 ppm (7.5 mg/m3), short term exposure limit 6 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 3 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 3 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2.5 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 3 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 3 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 3 ppm, short term exposure limit 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 3 ppm (8 mg/m3), short term exposure limit 6 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 3 ppm (8 mg/m3), short term exposure limit 6 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 3 ppm (7.6 mg/m3), short term exposure limit 5 ppm (15 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 6 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 6 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHANOLAMINE-air 10 hour time-weighted average 3 ppm;
short term exposure limit 6 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 04980;
Number of Industries 201;
Total Number of Facilities 33,147;
Number of Occupations 144;
Total Number of Employees Exposed 499,260
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 04980;
Number of Industries 274;
Total Number of Facilities 56,219;
Number of Occupations 190;
Total Number of Employees Exposed 1,163,087;
Total Number of Female Employees Exposed 328,648


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for scrubbing acid gases and in production of detergents and alkanolamide surfactants
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007; compounds II, 3509
NIOSH Analytical Method, 1996: Aminoethanol compounds II, 3509


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
KBMEAL Kosmicheskaya Biologiya i Meditsina. Space Biology and Medicine. (Moscow, USSR) V.1-7, 1967-73. For publisher information, see KBAMAJ.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used for scrubbing acid gases and in production of detergents and alkanolamide surfactants

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Primary Irritant

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